{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:24:03Z","timestamp":1792783443695,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Padova","id":[{"id":"https:\/\/ror.org\/00240q980","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Vitamin D deficiency (VDD) is common in older adults with osteoporosis, but its prevalence, determinants, and clinical impact in hip fracture (HF) patients remain incompletely defined. This study investigated the prevalence of VDD, associated factors, and 12-month outcomes in HF patients managed within a Fracture Liaison Service program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, 934 patients hospitalized for HF were enrolled between March 2023 and March 2025. VDD was defined as serum 25-hydroxyvitamin D [25-(OH)D]\u2009&lt;\u200950 nmol\/L. Clinical characteristics, laboratory parameters, and 12-month outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall VDD prevalence was 53.6%, with a median 25-(OH)D concentration of 22 nmol\/L among deficient patients. Independent predictors of VDD were male sex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), diabetes mellitus (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), dementia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), and active smoking (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), while prior vitamin D supplementation was negatively associated (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Decision tree analysis showed VDD prevalence ranging from 17.2% to 86.3% across patient phenotypes. Patients with VDD showed higher levels of bone turnover markers. In unadjusted analyses, VDD was associated with higher 12-month mortality (HR 1.65, 95% CI 1.12\u20132.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010), an association attenuated and no longer significant after adjustment for age, sex, and comorbidity burden (HR 1.31, 95% CI 0.88\u20131.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.188). No associations were observed between VDD and rehospitalization or refracture rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>VDD is highly prevalent in HF patients. Although associated with higher mortality in unadjusted analyses, this relationship appears largely explained by comorbidity burden. These findings highlight the importance of recognizing VDD and implementing targeted vitamin D supplementation strategies in high-risk HF populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40618-026-02952-x","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:44:42Z","timestamp":1782539082000},"page":"2913-2924","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence, predictors, and clinical impact of vitamin D deficiency on 12-month outcomes in hip fracture patients"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0409-4449","authenticated-orcid":false,"given":"Gaetano Paride","family":"Arcidiacono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1426-1452","authenticated-orcid":false,"given":"Marco 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The members of the Hip-POS working group also declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed in accordance with the 1964 Helsinki declaration and its later amendments. The study was authorized by the local Ethics Committee (Comitato Etico Territoriale Area Centro-Est Veneto, 442n\/AO\/23). 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