{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:31:16Z","timestamp":1793399476361,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-026-03016-w","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:44:23Z","timestamp":1786358663000},"page":"3335-3343","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinant factors for headache at acromegaly diagnosis: findings from an Iberian multicenter study encompassing 726 patients"],"prefix":"10.1007","volume":"49","author":[{"given":"Marta Vaz","family":"Lopes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"de Grin\u00e9 Severino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ema Lacerda","family":"Nobre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Miguel","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fajardo-Monta\u00f1ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edelmiro Men\u00e9ndez","family":"Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina","family":"Biagetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Garc\u00eda-Centeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Gonz\u00e1lez","family":"Fernand\u00e9z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Ollero Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Irigaray","family":"Echarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cordido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lozano-Aida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Vidal-Ostos","family":"De Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Guerrero-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Novo-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Tenorio-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Moure Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Paja","family":"Fano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Rodr\u00edguez","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario Oliva","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada Gonz\u00e1lez","family":"Molero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Marazuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4959-5725","authenticated-orcid":false,"given":"Pedro","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"5","key":"3016_CR1","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/head.14927","volume":"65","author":"G Giuliani","year":"2025","unstructured":"Giuliani G, Costa D, Pellicano C, Gargiulo P, Virili C, Di Piero V, Altieri M (2025) Headache characteristics in acromegaly: Only a secondary disorder? Headache 65(5):826\u2013834","journal-title":"Headache"},{"issue":"1","key":"3016_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10194-008-0084-0","volume":"10","author":"JA Gondim","year":"2009","unstructured":"Gondim JA, de Almeida JP, de Albuquerque LA, Schops M, Gomes E, Ferraz T (2009) Headache associated with pituitary tumors. J Headache Pain 10(1):15\u201320","journal-title":"J Headache Pain"},{"issue":"3","key":"3016_CR3","doi-asserted-by":"publisher","first-page":"e220138","DOI":"10.1530\/ERC-22-0138","volume":"30","author":"S Kaniuka-Jakubowska","year":"2023","unstructured":"Kaniuka-Jakubowska S, Levy MJ, Pal A, Abeyaratne D, Drake WM, Kyriakakis N, Murray RD, Orme SM, Gohil S, Brooke A, Leese GP, Korbonits M, Wass JA (2023) A study of acromegaly-associated headache with somatostatin analgesia. Endocr Relat Cancer 30(3):e220138","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"3016_CR4","first-page":"293","volume":"62","author":"M Mercado","year":"2004","unstructured":"Mercado M, Espinosa de los Monteros AL, Sosa E, Cheng S, Mendoza V, Hernandez I, Sandoval C, Guinto G, Molina M (2004) Clinical-biochemical correlations in acromegaly at diagnosis and the real prevalence of biochemically discordant disease. Horm Res 62(6):293\u2013299","journal-title":"Horm Res"},{"issue":"4","key":"3016_CR5","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s11102-023-01322-7","volume":"26","author":"TNA Slagboom","year":"2023","unstructured":"Slagboom TNA, van Bunderen CC, De Vries R, Bisschop PH, Drent ML (2023) Prevalence of clinical signs, symptoms and comorbidities at diagnosis of acromegaly: a systematic review in accordance with PRISMA guidelines. Pituitary 26(4):319\u2013332","journal-title":"Pituitary"},{"key":"3016_CR6","doi-asserted-by":"crossref","unstructured":"Araujo-Castro M, Marques P, Cardoso LM, Pascual-Corrales E, Refardt J, Neggers S, Jimenez Cassinello JM, Marazuela M, Puig-Domingo M, Biagetti B (2026) Acromegaly and Cardiovascular Disease: Mechanisms, Clinical Impact, and Evolving Management. Endocr Rev bnag011","DOI":"10.1210\/endrev\/bnag011"},{"issue":"2","key":"3016_CR7","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s11910-010-0166-7","volume":"11","author":"MJ Levy","year":"2011","unstructured":"Levy MJ (2011) The association of pituitary tumors and headache. Curr Neurol Neurosci Rep 11(2):164\u2013170","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"8","key":"3016_CR8","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1177\/0333102419839963","volume":"39","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Pan Q, Jiang H, Yang G, Chen L, Qin G, Zhou J (2019) A prospective study of headache and neuropeptides in patients with pituitary adenomas. Cephalalgia 39(8):1049\u20131057","journal-title":"Cephalalgia"},{"issue":"Pt 8","key":"3016_CR9","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1093\/brain\/awh525","volume":"128","author":"MJ Levy","year":"2005","unstructured":"Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ (2005) The clinical characteristics of headache in patients with pituitary tumours. Brain 128(Pt 8):1921\u20131930","journal-title":"Brain"},{"issue":"2","key":"3016_CR10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3171\/2008.8.JNS08805","volume":"110","author":"M Fleseriu","year":"2009","unstructured":"Fleseriu M, Yedinak C, Campbell C, Delashaw JB (2009) Significant headache improvement after transsphenoidal surgery in patients with small sellar lesions. J Neurosurg 110(2):354\u2013358","journal-title":"J Neurosurg"},{"issue":"10","key":"3016_CR11","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/BF03346442","volume":"31","author":"A Giustina","year":"2008","unstructured":"Giustina A, Gola M, Colao A, De Marinis L, Losa M, Sicolo N, Ghigo E (2008) The management of the patient with acromegaly and headache: a still open clinical challenge. J Endocrinol Invest 31(10):919\u2013924","journal-title":"J Endocrinol Invest"},{"issue":"11","key":"3016_CR12","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/s41574-025-01148-2","volume":"21","author":"S Melmed","year":"2025","unstructured":"Melmed S, di Filippo L, Fleseriu M, Mercado M, Karavitaki N, Gurnell M, Salvatori R, Tsagarakis S, Losa M, Maffei P, Pereira AM, Geer EB, Katznelson L, van der Lely AJ, Bollerslev J, Esposito D, Webb SM, Zatelli MC, Valassi E, Neggers S, Chanson P, Ho KKY, Ioachimescu AG, Biller BMK, Samson SL, Kaiser UB, Schilbach K, Luque RM, Casanueva FF, Shimon I, Boguszewski CL, Biermasz N, Colao A, Pirchio R, Lamberts SWJ, Kadioglu P, Buchfelder M, Frara S, Chiloiro S, Petersenn S, Gadelha MR, Puig-Domingo M, Luger A, Brue T, Beckers A, Ferone D, Clemmons DR, Greenman Y, Marazuela M, Mortini P, Strasburger CJ, Giustina A (2025) Consensus on acromegaly therapeutic outcomes: an update. Nat Rev Endocrinol 21(11):718\u2013737","journal-title":"Nat Rev Endocrinol"},{"issue":"12","key":"3016_CR13","doi-asserted-by":"publisher","first-page":"e2178","DOI":"10.1210\/clinem\/dgae126","volume":"109","author":"M Araujo-Castro","year":"2024","unstructured":"Araujo-Castro M, Biagetti B, Menendez Torre E, Novoa-Testa I, Cordido F, Pascual Corrales E, Rodriguez Berrocal V, Guerrero-Perez F, Vicente A, Percovich JC, Garcia Centeno R, Gonzalez L, Ollero Garcia MD, Irigaray Echarri A, Moure Rodriguez MD, Novo-Rodriguez C, Calatayud M, Villar R, Bernabeu I, Alvarez-Escola C, Benitez Valderrama P, Tenorio-Jimenez C, Abellan Galiana P, Venegas Moreno E, Gonzalez Molero I, Iglesias P, Blanco C, De Vidal-Ostos F, de Miguel P, Lopez Mezquita E, Hanzu F, Aldecoa I, Lamas C, Aznar S, Aulinas A, Calabrese A, Gracia P, Recio-Cordova JM, Aviles M, Asensio-Wandosel D, Sampedro M, Ruz-Caracuel I, Camara R, Paja M, Fajardo-Montanana C, Marazuela M, Puig-Domingo M (2024) Differences Between GH- and PRL-Cosecreting and GH-Secreting Pituitary Adenomas: a Series of 604 Cases. J Clin Endocrinol Metab 109(12):e2178\u2013e2187","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"3016_CR14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11102-025-01586-1","volume":"28","author":"M Araujo-Castro","year":"2025","unstructured":"Araujo-Castro M, Garcia-Centeno R, Gonzalez L, Lacerda Nobre E, de Grine Severino M, Goi J, Perez Pena MM, Menendez Torre E, Lozano Aida C, Novoa-Testa I, Cordido F, Sanchon R, Guerrero-Perez F, Oliva Rodriguez R, Rodriguez-Jimenez B, Ollero Garcia MD, Irigaray Echarri A, Simo-Servat A, Moure Rodriguez MD, Novo-Rodriguez C, Calatayud M, Villar-Taibo R, Bernabeu I, Tenorio-Jimenez C, Gonzalez Molero I, Iglesias P, Blanco C, Vidal-Ostos De Lara F, Aulinas A, Asla Roca Q, Paja Fano M, Rivera Martinez A, Cardoso LM, Marques P, Giustina A, Marazuela M, Puig-Domingo M, Biagetti B (2025) Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly. Pituitary 28(6):119","journal-title":"Pituitary"},{"issue":"4","key":"3016_CR15","first-page":"610","volume":"33","author":"E Knosp","year":"1993","unstructured":"Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33(4):610\u2013617 discussion 617\u2013618","journal-title":"Neurosurgery"},{"issue":"3","key":"3016_CR16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1530\/eje.1.02112","volume":"154","author":"A Colao","year":"2006","unstructured":"Colao A, Pivonello R, Auriemma RS, De Martino MC, Bidlingmaier M, Briganti F, Tortora F, Burman P, Kourides IA, Strasburger CJ, Lombardi G (2006) Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance. Eur J Endocrinol 154(3):467\u2013477","journal-title":"Eur J Endocrinol"},{"key":"3016_CR17","doi-asserted-by":"publisher","first-page":"774686","DOI":"10.3389\/fendo.2021.774686","volume":"12","author":"L Das","year":"2021","unstructured":"Das L, Gupta N, Dutta P, Walia R, Vaiphei K, Rai A, Radotra BD, Gupta K, Sreedharanunni S, Ahuja CK, Bhansali A, Tripathi M, Sood R, Dhandapani S (2021) Early Initiation of Temozolomide Therapy May Improve Response in Aggressive Pituitary Adenomas. Front Endocrinol (Lausanne) 12:774686","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3016_CR18","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.wneu.2017.09.017","volume":"108","author":"JL Sanmillan","year":"2017","unstructured":"Sanmillan JL, Torres-Diaz A, Sanchez-Fernandez JJ, Lau R, Ciller C, Puyalto P, Gabarros A (2017) Radiologic Predictors for Extent of Resection in Pituitary Adenoma Surgery. A Single-Center Study. World Neurosurg 108:436\u2013446","journal-title":"World Neurosurg"},{"issue":"2","key":"3016_CR19","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1210\/clinem\/dgaa868","volume":"106","author":"LHA Broersen","year":"2021","unstructured":"Broersen LHA, Zamanipoor Najafabadi AH, Pereira AM, Dekkers OM, van Furth WR, Biermasz NR (2021) Improvement in Symptoms and Health-Related Quality of Life in Acromegaly Patients: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab 106(2):577\u2013587","journal-title":"J Clin Endocrinol Metab"},{"issue":"16","key":"3016_CR20","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1056\/NEJM200004203421604","volume":"342","author":"PJ Trainer","year":"2020","unstructured":"Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML, Besser GM, Scarlett JA, Thorner MO, Parkinson C, Klibanski A, Powell JS, Barkan AL, Sheppard MC, Malsonado M, Rose DR, Clemmons DR, Johannsson G, Bengtsson BA, Stavrou S, Kleinberg DL, Cook DM, Phillips LS, Bidlingmaier M, Strasburger CJ, Hackett S, Zib K, Bennett WF, Davis RJ (2020) Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med 342(16):1171\u20131177","journal-title":"N Engl J Med"},{"issue":"10","key":"3016_CR21","doi-asserted-by":"publisher","first-page":"4759","DOI":"10.1210\/jc.2003-030518","volume":"88","author":"DR Clemmons","year":"2003","unstructured":"Clemmons DR, Chihara K, Freda PU, Ho KK, Klibanski A, Melmed S, Shalet SM, Strasburger CJ, Trainer PJ, Thorner MO (2003) Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm. J Clin Endocrinol Metab 88(10):4759\u20134767","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"3016_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11102-025-01504-5","volume":"28","author":"CR Scaf","year":"2025","unstructured":"Scaf CR, Altoe A, Ventura N, Vincent M, Kasuki L, Gadelha MR (2025) Headache in pituitary adenomas: frequency, characteristics and outcome after treatment. Pituitary 28(2):31","journal-title":"Pituitary"},{"issue":"3","key":"3016_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.15274\/NRJ-2014-10052","volume":"27","author":"X Lv","year":"2014","unstructured":"Lv X, Wu Z, Li Y (2014) Innervation of the cerebral dura mater. Neuroradiol J 27(3):293\u2013298","journal-title":"Neuroradiol J"},{"issue":"2","key":"3016_CR24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s12020-017-1266-9","volume":"56","author":"S Siegel","year":"2017","unstructured":"Siegel S, Weber Carneiro R, Buchfelder M, Kleist B, Grzywotz A, Buslei R, Bingel U, Brabant G, Schenk T, Kreitschmann-Andermahr I (2017) Presence of headache and headache types in patients with tumors of the sellar region-can surgery solve the problem? Results of a prospective single center study. Endocrine 56(2):325\u2013335","journal-title":"Endocrine"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-026-03016-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-026-03016-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-026-03016-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:01:28Z","timestamp":1793397688000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-026-03016-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["3016"],"URL":"https:\/\/doi.org\/10.1007\/s40618-026-03016-w","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"25 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by the Ethics Committee of Hospital Universitario Ram\u00f3n y Cajal (approval date: 2 June 2023, ACTA 454).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}