{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:53:44Z","timestamp":1777870424678,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s40620-014-0081-0","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T22:07:36Z","timestamp":1395698856000},"page":"265-273","source":"Crossref","is-referenced-by-count":0,"title":["Is there B cell involvement in a rat model of spontaneous idiopathic nephrotic syndrome treated with LF15-0195?"],"prefix":"10.1093","volume":"27","author":[{"given":"Ludmilla","family":"Le Berre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Tilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Dantal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"81_CR1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1172\/JCI0212858","volume":"109","author":"L Berre Le","year":"2002","unstructured":"Le Berre L, Godfrin Y, Gunther E et al (2002) Extrarenal effects on the pathogenesis and relapse of idiopathic nephrotic syndrome in Buffalo\/Mna rats. J Clin Invest 109:491\u2013498","journal-title":"J Clin Invest"},{"issue":"1","key":"81_CR2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1681\/ASN.2007111244","volume":"20","author":"L Berre Le","year":"2009","unstructured":"Le Berre L, Bruneau S, Naulet J et al (2009) Induction of T regulatory cells attenuates idiopathic nephrotic syndrome. J Am Soc Nephrol 20(1):57\u201367","journal-title":"J Am Soc Nephrol"},{"key":"81_CR3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2220\/biomedres.4.105","volume":"4","author":"F Kato","year":"1983","unstructured":"Kato F, Watanabe M, Matsuyama M (1983) Nephrotic syndrome in spontaneous thymoma rats, Buffalo\/Mna. Biomed Res 4:105","journal-title":"Biomed Res"},{"key":"81_CR4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000183718","volume":"43","author":"T Nakamura","year":"1986","unstructured":"Nakamura T, Oite T, Shimizu F et al (1986) Sclerotic lesions in the glomeruli of Buffalo\/Mna rats. Nephron 43:50","journal-title":"Nephron"},{"key":"81_CR5","unstructured":"Matsuyama M, Nagayo T (1977) Development of thymoma and myasthenia in Buffalo\/Mna rats. In: Proc. Jpn. Cancer assoc. 36th Annu. Meet, vol. 30"},{"key":"81_CR6","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/(SICI)1097-4598(199812)21:12<1655::AID-MUS5>3.0.CO;2-F","volume":"21","author":"K Iwasa","year":"1998","unstructured":"Iwasa K, Komai K, Takamori M (1998) Spontaneous thymoma rat as a model for myasthenic weakness caused by anti-ryanodine receptor antibodies. Muscle Nerve 21:1655","journal-title":"Muscle Nerve"},{"key":"81_CR7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000185890","volume":"54","author":"M Matsuyama","year":"1990","unstructured":"Matsuyama M, Ogiu T, Kontani K et al (1990) Genetic regulation of the development of glomerular sclerotic lesions in the BUF\/Mna rat. Nephron 54:334","journal-title":"Nephron"},{"key":"81_CR8","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s003359900888","volume":"9","author":"S Murayama","year":"1998","unstructured":"Murayama S, Yagyu S, Higo K et al (1998) A genetic locus susceptible to the overt proteinuria in BUF\/Mna rat. Mamm Genome 9:886","journal-title":"Mamm Genome"},{"issue":"1","key":"81_CR9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00335-007-9078-5","volume":"19","author":"K Akiyama","year":"2008","unstructured":"Akiyama K, Morita H, Suetsugu S et al (2008) Actin-related protein 3 (Arp3) is mutated in proteinuric BUF\/Mna rats. Mamm Genome 19(1):41\u201350","journal-title":"Mamm Genome"},{"key":"81_CR10","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1111\/j.1523-1755.2005.00664.x","volume":"68","author":"L Berre Le","year":"2005","unstructured":"Le Berre L, Herve C, Buzelin F et al (2005) Renal macrophage activation and Th2 polarization precedes the development of nephrotic syndrome in Buffalo\/Mna rats. Kidney Int 68:2079","journal-title":"Kidney Int"},{"issue":"3","key":"81_CR11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1600-6143.2010.03336.x","volume":"11","author":"L Texier Le","year":"2011","unstructured":"Le Texier L, Thebault P, Lavault A et al (2011) Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile. Am J Transplant 11(3):429\u2013438","journal-title":"Am J Transplant"},{"issue":"6","key":"81_CR12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00467-001-0817-7","volume":"17","author":"MJ Kemper","year":"2002","unstructured":"Kemper MJ, Altrogge H, Ganschow R, M\u00fcller-Wiefel DE (2002) Serum levels of immunoglobulins and IgG subclasses in steroid sensitive nephrotic syndrome. Pediatr Nephrol 17(6):413\u2013417","journal-title":"Pediatr Nephrol"},{"issue":"4","key":"81_CR13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5414\/CNP60242","volume":"60","author":"MJ Kemper","year":"2003","unstructured":"Kemper MJ, Meyer-Jark T, Lilova M, M\u00fcller-Wiefel DE (2003) Combined T- and B-cell activation in childhood steroid-sensitive nephrotic syndrome. Clin Nephrol 60(4):242\u2013247","journal-title":"Clin Nephrol"},{"issue":"3","key":"81_CR14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00467-009-1376-6","volume":"25","author":"A Prytu\u0142a","year":"2010","unstructured":"Prytu\u0142a A, Iijima K, Kamei K et al (2010) Rituximab in refractory nephrotic syndrome. Pediatr Nephrol 25(3):461\u2013468","journal-title":"Pediatr Nephrol"},{"issue":"6","key":"81_CR15","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.2215\/CJN.09421010","volume":"6","author":"P Ravani","year":"2011","unstructured":"Ravani P, Magnasco A, Edefonti A et al (2011) Short-term effects of rituximab in children with steroid- and calcineurin-dependent nephrotic syndrome: a randomized controlled trial. Clin J Am Soc Nephrol 6(6):1308\u20131315","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"81_CR16","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/ndt\/gfr405","volume":"27","author":"AL Sellier-Leclerc","year":"2012","unstructured":"Sellier-Leclerc AL, Baudouin V, Kwon T et al (2012) Rituximab in steroid-dependent idiopathic nephrotic syndrome in childhood\u2014follow-up after CD19 recovery. Nephrol Dial Transplant 27(3):1083\u20131089","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"81_CR17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00467-012-2319-1","volume":"28","author":"S Ito","year":"2013","unstructured":"Ito S, Kamei K, Ogura M et al (2013) Survey of rituximab treatment for childhood-onset refractory nephrotic syndrome. Pediatr Nephrol 28(2):257\u2013264","journal-title":"Pediatr Nephrol"},{"key":"81_CR18","doi-asserted-by":"crossref","unstructured":"Kemper MJ, Lehnhardt A, Zawischa A, Oh J (2013) Is rituximab effective in childhood nephrotic syndrome? Yes and no. Pediatr Nephrol. doi: 10.1007\/s00467-013-2529-1","DOI":"10.1007\/s00467-013-2529-1"},{"issue":"85","key":"81_CR19","doi-asserted-by":"crossref","first-page":"85ra46","DOI":"10.1126\/scitranslmed.3002231","volume":"3","author":"A Fornoni","year":"2011","unstructured":"Fornoni A, Sageshima J, Wei C et al (2011) Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med 3(85):85ra46","journal-title":"Sci Transl Med"},{"issue":"3","key":"81_CR20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/ki.2012.444","volume":"83","author":"H Munyentwali","year":"2013","unstructured":"Munyentwali H, Bouachi K, Audard V et al (2013) Rituximab is an efficient and safe treatment in adults with steroid-dependent minimal change disease. Kidney Int 83(3):511\u2013516","journal-title":"Kidney Int"},{"issue":"11","key":"81_CR21","doi-asserted-by":"crossref","first-page":"e15007","DOI":"10.1371\/journal.pone.0015007","volume":"5","author":"EW Nduati","year":"2010","unstructured":"Nduati EW, Ng DH, Ndungu FM et al (2010) Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice. PLoS ONE 5(11):e15007","journal-title":"PLoS ONE"},{"key":"81_CR22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJM199401063300102","volume":"330","author":"J Dantal","year":"1994","unstructured":"Dantal J, Bigot E, Bogers W et al (1994) Effect of plasma protein adsorption on protein excretion in kidney-transplant recipients with recurrent nephrotic syndrome. N Engl J Med 330:7","journal-title":"N Engl J Med"},{"issue":"9","key":"81_CR23","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1681\/ASN.V991709","volume":"9","author":"J Dantal","year":"1998","unstructured":"Dantal J, Godfrin Y, Koll R et al (1998) Antihuman immunoglobulin affinity immunoadsorption strongly decreases proteinuria in patients with relapsing nephrotic syndrome. J Am Soc Nephrol 9(9):1709\u20131715","journal-title":"J Am Soc Nephrol"},{"key":"81_CR24","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/00007890-198912000-00031","volume":"48","author":"PG Kerr","year":"1989","unstructured":"Kerr PG, Atkins RC (1989) The effects of deoxyspergualin on lymphocytes and monocytes in vivo and in vitro. Transplantation 48:1048","journal-title":"Transplantation"},{"key":"81_CR25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0192-0561(87)90123-8","volume":"9","author":"G Dickneite","year":"1987","unstructured":"Dickneite G, Schorlemmer HU, Sedlacek HH (1987) Decrease of mononuclear phagocyte cell functions and prolongation of graft survival in experimental transplantation by (\u00b1)-15-deoxyspergualin. Int J Immunopharmacol 9:559","journal-title":"Int J Immunopharmacol"},{"key":"81_CR26","first-page":"155","volume":"44","author":"AM Waaga","year":"1996","unstructured":"Waaga AM, Krzymanski M, Ulrichs K et al (1996) In vitro analysis of the mode of action of the immuno-suppressive drug 15-deoxyspergualin. Arch Immunol Ther Exp 44:155","journal-title":"Arch Immunol Ther Exp"},{"key":"81_CR27","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.4049\/jimmunol.153.9.3908","volume":"153","author":"PH Hoeger","year":"1994","unstructured":"Hoeger PH, Tepper MA, Faith A et al (1994) Immunosuppressant deoxyspergualin inhibits antigen processing in monocytes. J Immunol 153:3908","journal-title":"J Immunol"},{"key":"81_CR28","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.1411548","volume":"258","author":"SG Nadler","year":"1992","unstructured":"Nadler SG, Tepper MA, Schacter B, Mazzucco CE (1992) Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins. Science 258:484","journal-title":"Science"},{"key":"81_CR29","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.4049\/jimmunol.155.5.2427","volume":"155","author":"MA Tepper","year":"1995","unstructured":"Tepper MA, Nadler SG, Esselstyn JM, Sterbenz KG (1995) Deoxyspergualin inhibits kappa light chain expression in 70Z\/3 pre-B cells by blocking lipopolysaccharide-induced NF-kappa B activation. J Immunol 155:2427","journal-title":"J Immunol"},{"key":"81_CR30","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/j.1525-1594.1996.tb04555.x","volume":"20","author":"H Amemiya","year":"1996","unstructured":"Amemiya H (1996) 15-Deoxyspergualin: a newly developed immunosuppressive agent and its mechanism of action and clinical effect: a review. Japan Collaborative Transplant Study Group for NKT-01. Artif Organs 20:832","journal-title":"Artif Organs"},{"issue":"23","key":"81_CR31","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1021\/jm991043x","volume":"42","author":"L Lebreton","year":"1999","unstructured":"Lebreton L, Jost E, Carboni B et al (1999) Structure-immunosuppressive activity relationships of new analogues of 15-deoxyspergualin. 2. Structural modifications of the spermidine moiety. J Med Chem 42(23):4749\u20134763","journal-title":"J Med Chem"},{"issue":"4","key":"81_CR32","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.TP.0000071202.91772.90","volume":"76","author":"D Zhou","year":"2003","unstructured":"Zhou D, O\u2019Brien C, Shum J et al (2003) LF 15-0195, a novel immunosuppressive agent prevents rejection and induces operational tolerance in a mouse cardiac allograft model. Transplantation 76(4):644\u2013650","journal-title":"Transplantation"},{"key":"81_CR33","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.4049\/jimmunol.170.3.1304","volume":"170","author":"WP Min","year":"2003","unstructured":"Min WP, Zhou D, Ichim TE et al (2003) Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 170:1304","journal-title":"J Immunol"},{"key":"81_CR34","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.4049\/jimmunol.168.10.5058","volume":"168","author":"E Chiffoleau","year":"2002","unstructured":"Chiffoleau E, Beriou G, Dutartre P et al (2002) Role for thymic and splenic regulatory CD4+ T cells induced by donor dendritic cells in allograft tolerance by LF15-0195 treatment. J Immunol 168:5058","journal-title":"J Immunol"},{"issue":"8","key":"81_CR35","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1034\/j.1600-6143.2002.20808.x","volume":"2","author":"E Chiffoleau","year":"2002","unstructured":"Chiffoleau E, B\u00e9riou G, Dutartre P et al (2002) Induction of donor-specific allograft tolerance by short-term treatment with LF15-0195 after transplantation. Evidence for a direct effect on T-cell differentiation. Am J Transplant 2(8):745\u2013757","journal-title":"Am J Transplant"},{"issue":"9","key":"81_CR36","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/01.TP.0000057245.59998.95","volume":"75","author":"H Wang","year":"2003","unstructured":"Wang H, Hosiawa KA, Garcia B et al (2003) Attenuation of acute xenograft rejection by short-term treatment with LF15-0195 and monoclonal antibody against CD45RB in a rat-to-mouse cardiac transplantation model. Transplantation 75(9):1475\u20131481","journal-title":"Transplantation"},{"issue":"4","key":"81_CR37","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.4049\/jimmunol.170.4.2179","volume":"170","author":"V Duplan","year":"2003","unstructured":"Duplan V, Dutartre P, Mars LT et al (2003) LF 15-0195 inhibits the development of rat central nervous system autoimmunity by inducing long-lasting tolerance in autoreactive CD4 T cells. J Immunol 170(4):2179\u20132185","journal-title":"J Immunol"},{"issue":"1\u20132","key":"81_CR38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-5728(02)00189-3","volume":"129","author":"V Duplan","year":"2002","unstructured":"Duplan V, Dutartre P, Druet P, Saoudi A (2002) LF 15-0195 prevents from the development and inhibits the progression of rat experimental autoimmune myasthenia gravis. J Neuroimmunol 129(1\u20132):115\u2013124","journal-title":"J Neuroimmunol"},{"issue":"3","key":"81_CR39","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/S0041-1345(01)01977-7","volume":"33","author":"P Ducoroy","year":"2001","unstructured":"Ducoroy P, de Fornel D, Chirade F et al (2001) The immunosuppressant LF 15-0195 prevents collagen-induced arthritis with IL-10 down-regulation. Transplant Proc 33(3):2142\u20132145","journal-title":"Transplant Proc"},{"key":"81_CR40","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1046\/j.1523-1755.2001.00940.x","volume":"60","author":"GH Tesch","year":"2001","unstructured":"Tesch GH, Hill PA, Wei M et al (2001) LF15-0195 prevents the induction and inhibits the progression of rat anti-GBM disease. Kidney Int 60:1354","journal-title":"Kidney Int"},{"key":"81_CR41","first-page":"1078","volume":"23","author":"K Takahashi","year":"1991","unstructured":"Takahashi K, Tanabe K, Ooba S et al (1991) Prophylactic use of a new immunosuppressive agent, deoxyspergualin, in patients with kidney transplantation from ABO-incompatible or preformed antibody-positive donors. Transplant Proc 23:1078\u20131082","journal-title":"Transplant Proc"},{"issue":"2","key":"81_CR42","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/01.ASN.0000048716.42876.14","volume":"14","author":"R Birck","year":"2003","unstructured":"Birck R, Warnatz K, Lorenz HM et al (2003) 15-Deoxyspergualin in patients with refractory ANCA-associated systemic vasculitis: a six-month open-label trial to evaluate safety and efficacy. J Am Soc Nephrol 14(2):440\u2013447","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"81_CR43","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/ar3268","volume":"13","author":"HM Lorenz","year":"2011","unstructured":"Lorenz HM, Schmitt WH, Tesar V et al (2011) Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study. Arthritis Res Ther 13(2):R36","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"81_CR44","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s10157-005-0396-1","volume":"10","author":"H Imai","year":"2006","unstructured":"Imai H, Hotta O, Yoshimura M et al (2006) Deoxyspergualin, an immunosuppressant, in patients suffering from nephropathies with crescent formation: an open-label trial to evaluate safety and efficacy. Clin Exp Nephrol 10(1):40\u201354","journal-title":"Clin Exp Nephrol"},{"key":"81_CR45","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1097\/01.tp.0000185198.07663.ba","volume":"80","author":"JM Heslan","year":"2005","unstructured":"Heslan JM, Beriou G, Le Luduec JB et al (2005) Accumulation of T cells with potent regulatory properties and restricted Vbeta7-TCR rearrangements in tolerated allografts. Transplantation 80:1476","journal-title":"Transplantation"},{"issue":"3","key":"81_CR46","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1189\/jlb.1102582","volume":"74","author":"J Yang","year":"2003","unstructured":"Yang J, Bernier SM, Ichim TE et al (2003) LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity. J Leukoc Biol 74(3):438\u2013447","journal-title":"J Leukoc Biol"},{"issue":"9","key":"81_CR47","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nm.1857","volume":"14","author":"C Faul","year":"2008","unstructured":"Faul C, Donnelly M, Merscher-Gomez S et al (2008) The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med 14(9):931\u2013938","journal-title":"Nat Med"},{"key":"81_CR48","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1084\/jem.183.6.2427","volume":"183","author":"B Wang","year":"1996","unstructured":"Wang B, Benoist C, Mathis D (1996) The immunosuppressant 15-deoxyspergualin reveals commonality between preT and preB cell differentiation. J Exp Med 183:2427\u20132436","journal-title":"J Exp Med"},{"key":"81_CR49","doi-asserted-by":"crossref","first-page":"727","DOI":"10.4049\/jimmunol.137.2.727","volume":"137","author":"JM Fidler","year":"1986","unstructured":"Fidler JM, DeJoy SQ, Gibbons JJ Jr (1986) Selective immunomodulation by the antineoplastic agent mitoxantrone. I. Suppression of B lymphocyte function. J Immunol 137:727\u2013732","journal-title":"J Immunol"},{"key":"81_CR50","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.4049\/jimmunol.136.8.2747","volume":"136","author":"JM Fidler","year":"1986","unstructured":"Fidler JM, DeJoy SQ, Smith FR et al (1986) Selective immunomodulation by the antineoplastic agent mitoxantrone. II. Nonspecific adherent suppressor cells derived from mitoxantrone-treated mice. J Immunol 136:2747\u20132754","journal-title":"J Immunol"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-014-0081-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40620-014-0081-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-014-0081-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:58:12Z","timestamp":1777564692000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/27\/3\/265\/8372300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["81"],"URL":"https:\/\/doi.org\/10.1007\/s40620-014-0081-0","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}