{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:53:36Z","timestamp":1777870416713,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T00:00:00Z","timestamp":1412812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s40620-014-0147-z","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T06:15:59Z","timestamp":1412748959000},"page":"627-634","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Angiotensin II type 1 receptor blockade ameliorates proteinuria in puromycin aminonucleoside nephropathy by inhibiting the reduction of NEPH1 and nephrin"],"prefix":"10.1093","volume":"27","author":[{"given":"Aya","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Fukusumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsumi","family":"Kayaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukina","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,10,9]]},"reference":[{"key":"147_CR1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1056\/NEJM199604113341502","volume":"334","author":"G Maschio","year":"1996","unstructured":"Maschio G, Alberti D, Janin G, Locatelli F, Mann JF, Motolese M, Ponticelli C, Ritz E, Zucchelli P (1996) Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting Enzyme Inhibition in Progressive Renal Insufficiency study group. N Engl J Med 334:939\u2013945. doi: 10.1056\/NEJM199604113341502","journal-title":"N Engl J Med"},{"key":"147_CR2","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0140-6736(96)11445-8","volume":"349","author":"The GISEN group (Gruppo Italiano di Studi Epidemiologici in Nefrologia)","year":"1997","unstructured":"The GISEN group (Gruppo Italiano di Studi Epidemiologici in Nefrologia) (1997) Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet 349:1857\u20131863. doi: 10.1016\/S0140-6736(96)11445-8","journal-title":"Lancet"},{"key":"147_CR3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0140-6736(98)10363-X","volume":"354","author":"P Ruggenenti","year":"1999","unstructured":"Ruggenenti P, Perna A, Gherardi G, Garini G, Zoccali C, Salvadori M, Scolari F, Schena FP, Remuzzi G (1999) Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with non-nephrotic proteinuria. Lancet 354:359\u2013364. doi: 10.1016\/S0140-6736(98)10363-X","journal-title":"Lancet"},{"key":"147_CR4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMoa011161","volume":"345","author":"BM Brenner","year":"2001","unstructured":"Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S (2001) RENAAL Study Investigators: effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345:861\u2013869. doi: 10.1056\/NEJMoa011161","journal-title":"N Engl J Med"},{"key":"147_CR5","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1172\/JCI115949","volume":"90","author":"RA Lafayette","year":"1992","unstructured":"Lafayette RA, Mayer G, Park SK, Meyer TW (1992) Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. J Clin Invest 90:766\u2013771. doi: 10.1172\/JCI115949","journal-title":"J Clin Invest"},{"key":"147_CR6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1681\/ASN.V4140","volume":"4","author":"A Remuzzi","year":"1993","unstructured":"Remuzzi A, Perico N, Amuchastegui CS, Malanchini B, Mazerska M, Battaglia C, Bertani T, Remuzzi G (1993) Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes. J Am Soc Nephrol 4:40\u201349","journal-title":"J Am Soc Nephrol"},{"key":"147_CR7","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1681\/ASN.V125941","volume":"12","author":"A Benigni","year":"2001","unstructured":"Benigni A, Tomasoni S, Gagliardini E, Zoja C, Grunkemeyer JA, Kalluri R, Remuzzi G (2001) Blocking angiotensin II synthesis\/activity preserves glomerular nephrin in rats with severe nephrosis. J Am Soc Nephrol 12:941\u2013948","journal-title":"J Am Soc Nephrol"},{"key":"147_CR8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1681\/ASN.V113477","volume":"11","author":"D Macconi","year":"2000","unstructured":"Macconi D, Ghilardi M, Bonassi ME, Mohamed EI, Abbate M, Colombi F, Remuzzi G, Remuzzi A (2000) Effect of angiotensin-converting enzyme inhibition on glomerular basement membrane permeability and distribution of zonula occludens-1 in MWF rats. J Am Soc Nephrol 11:477\u2013489","journal-title":"J Am Soc Nephrol"},{"key":"147_CR9","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1056\/NEJM199606203342507","volume":"334","author":"TL Goodfriend","year":"1996","unstructured":"Goodfriend TL, Elliott ME, Catt KJ (1996) Angiotensin receptors and their antagonists. N Engl J Med 334:1649\u20131654. doi: 10.1056\/NEJM199606203342507","journal-title":"N Engl J Med"},{"key":"147_CR10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","volume":"52","author":"M Gasparo de","year":"2000","unstructured":"de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T (2000) International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 52:415\u2013472","journal-title":"Pharmacol Rev"},{"key":"147_CR11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s101570070017","volume":"4","author":"H Kawachi","year":"2000","unstructured":"Kawachi H, Shimizu F (2000) Molecular composition and function of the slit diaphragm: nephrin, the molecular responsible for proteinuria. Clin Exp Nephrol 4:161\u2013172","journal-title":"Clin Exp Nephrol"},{"key":"147_CR12","doi-asserted-by":"crossref","first-page":"F173","DOI":"10.1152\/ajprenal.2000.278.2.F173","volume":"278","author":"H Pavenstadt","year":"2000","unstructured":"Pavenstadt H (2000) Roles of the podocyte in glomerular function. Am J Physiol Renal Physiol 278:F173\u2013F179","journal-title":"Am J Physiol Renal Physiol"},{"key":"147_CR13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1365-2796.2003.01207.x","volume":"254","author":"K Tryggvason","year":"2003","unstructured":"Tryggvason K, Bettersson E (2003) Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure. J Intern Med 254:216\u2013224. doi: 10.1046\/j.1365-2796.2003.01207","journal-title":"J Intern Med"},{"key":"147_CR14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4049\/jimmunol.141.3.807","volume":"141","author":"M Orikasa","year":"1988","unstructured":"Orikasa M, Matsui K, Oite T, Shimizu F (1988) Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody. J Immunol 141:807\u2013814","journal-title":"J Immunol"},{"key":"147_CR15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2249.1992.tb06461.x","volume":"88","author":"H Kawachi","year":"1992","unstructured":"Kawachi H, Orikasa M, Matsui K, Iwanaga T, Toyabe S, Oite T, Shimizu F (1992) Epitope-specific induction of mesangial lesions with proteinuria by a MoAb against mesangial cell surface antigen. Clin Exp Immunol 88:399\u2013404","journal-title":"Clin Exp Immunol"},{"key":"147_CR16","first-page":"F984","volume":"273","author":"H Kawachi","year":"1997","unstructured":"Kawachi H, Kurihara H, Topham PS, Brown D, Shia MA, Orikasa M, Shimizu F, Salant DJ (1997) Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes. Am J Physiol 273:F984\u2013F993","journal-title":"Am J Physiol"},{"key":"147_CR17","first-page":"450","volume":"22","author":"H Kawachi","year":"2009","unstructured":"Kawachi H, Han GD, Miyauchi N, Hashimoto T, Suzuki K, Shimizu F (2009) Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy. J Nephrol 22:450\u2013456","journal-title":"J Nephrol"},{"key":"147_CR18","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s001250100546","volume":"44","author":"F Bonnet","year":"2001","unstructured":"Bonnet F, Cooper ME, Kawachi H, Allen TJ, Boner G, Cao Z (2001) Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia 44:874\u2013877","journal-title":"Diabetologia"},{"key":"147_CR19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2353\/ajpath.2008.070196","volume":"172","author":"T Hidaka","year":"2008","unstructured":"Hidaka T, Suzuki Y, Yamashita M, Shibata T, Tanaka Y, Horikoshi S, Tomino Y (2008) Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration. Am J Pathol 172:603\u2013614. doi: 10.2353\/ajpath.2008.070196","journal-title":"Am J Pathol"},{"key":"147_CR20","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.2353\/ajpath.2007.060484","volume":"170","author":"K Suzuki","year":"2007","unstructured":"Suzuki K, Han GD, Miyauchi N, Hashimoto T, Nakatsue T, Fujioka Y, Koike H, Shimizu F, Kawachi H (2007) Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall. Am J Pathol 170:1841\u20131853. doi: 10.2353\/ajpath.2007.060484","journal-title":"Am J Pathol"},{"key":"147_CR21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1440-1797.2009.01256.x","volume":"15","author":"A Fukuda","year":"2010","unstructured":"Fukuda A, Fujimoto S, Iwatsubo S, Kawachi H, Kitamura K (2010) Effects of mineralocorticoid and angiotensin II receptor blockers on proteinuria and glomerular podocyte protein expression in a model of minimal change nephrotic syndrome. Nephrology (Carlton) 15:321\u2013326. doi: 10.1111\/j.1440-1797.2009.01256","journal-title":"Nephrology (Carlton)"},{"key":"147_CR22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI200318242","volume":"112","author":"G Liu","year":"2003","unstructured":"Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar YS, Chugh SS (2003) Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. J Clin Invest 112:209\u2013221. doi: 10.1172\/JCI18242","journal-title":"J Clin Invest"},{"key":"147_CR23","doi-asserted-by":"crossref","first-page":"9502","DOI":"10.1074\/jbc.M113.505743","volume":"289","author":"E Arif","year":"2014","unstructured":"Arif E, Rathore YS, Kumari B, Ashish F, Wong HN, Holzman LB, Nihalani D (2014) Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. J Biol Chem 289:9502\u20139518. doi: 10.1074\/jbc.M113.505743","journal-title":"J Biol Chem"},{"key":"147_CR24","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1152\/ajprenal.00075.2008","volume":"295","author":"Y Otaki","year":"2008","unstructured":"Otaki Y, Miyauchi N, Higa M, Takada A, Kuroda T, Gejyo F, Shimizu F, Kawachi H (2008) Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis. Am J Physiol Renal Physiol 295:1376\u20131387. doi: 10.1152\/ajprenal.00075.2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"147_CR25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/01.ASN.0000037401.02391.76","volume":"14","author":"H Kawachi","year":"2003","unstructured":"Kawachi H, Koike H, Kurihara H, Sakai T, Shimizu F (2003) Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli. J Am Soc Nephrol 14:46\u201356. doi: 10.1097\/01.ASN.0000037401.02391.76","journal-title":"J Am Soc Nephrol"},{"key":"147_CR26","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1046\/j.1523-1755.2000.00044.x","volume":"57","author":"H Kawachi","year":"2000","unstructured":"Kawachi H, Koike H, Kurihara H, Yaoita E, Orikasa M, Shia MA, Sakai T, Yamamoto T, Salant DJ, Shimizu F (2000) Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states. Kidney Int 57:1949\u20131961. doi: 10.1046\/j.1523-1755.2000.00044","journal-title":"Kidney Int"},{"key":"147_CR27","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1083\/jcb.98.4.1591","volume":"98","author":"D Kerjaschki","year":"1984","unstructured":"Kerjaschki D, Sharkey DJ, Farquhar MG (1984) Identification and characterization of podocalyxin\u2013the major sialoprotein of the renal glomerular epithelial cell. J Cell Biol 98:1591\u20131596","journal-title":"J Cell Biol"},{"key":"147_CR28","doi-asserted-by":"crossref","first-page":"14110","DOI":"10.1073\/pnas.0602587103","volume":"103","author":"I Quack","year":"2006","unstructured":"Quack I, Rump LC, Gerke P, Walther I, Vinke T, Vonend O, Grunwald T, Sellin L (2006) b-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity. Proc Natl Acad Sci USA 103:14110\u201314115. doi: 10.1073\/pnas.0602587103","journal-title":"Proc Natl Acad Sci USA"},{"key":"147_CR29","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1074\/jbc.C300012200","volume":"278","author":"H Sugimoto","year":"2003","unstructured":"Sugimoto H, Hamano Y, Charytan D, Cosgrove D, Kieran M, Sudhakar A, Kalluri R (2003) Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 278:12605\u201312608. doi: 10.1074\/jbc.C300012200","journal-title":"J Biol Chem"},{"key":"147_CR30","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/ndt\/gfl711","volume":"22","author":"VD Garovic","year":"2007","unstructured":"Garovic VD, Wagner SJ, Petrovic LM, Gray CE, Hall P, Sugimoto H, Kalluri R, Grande JP (2007) Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. Nephrol Dial Transplant 22:1136\u20131143. doi: 10.1093\/ndt\/gfl711","journal-title":"Nephrol Dial Transplant"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-014-0147-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40620-014-0147-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-014-0147-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:57:56Z","timestamp":1777564676000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/27\/6\/627\/8372225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,9]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["147"],"URL":"https:\/\/doi.org\/10.1007\/s40620-014-0147-z","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,9]]}}}