{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:48:09Z","timestamp":1789915689305,"version":"4.0.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s40620-016-0292-7","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T14:37:50Z","timestamp":1458311870000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Total and bone-specific alkaline phosphatase are associated with bone mineral density over time in end-stage renal disease patients starting dialysis"],"prefix":"10.1093","volume":"30","author":[{"given":"Annelie","family":"Bergman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rashid","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Haarhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Barany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Heimburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stenvinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Anderstam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"issue":"5","key":"292_CR1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1365-2796.2010.02269.x","volume":"268","author":"P Stenvinkel","year":"2010","unstructured":"Stenvinkel P (2010) Chronic kidney disease: a public health priority and harbinger of premature cardiovascular disease. J Intern Med 268(5):456\u2013467","journal-title":"J Intern Med"},{"key":"292_CR2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1038\/sj.ki.5001996","volume":"105","author":"M Ketteler","year":"2006","unstructured":"Ketteler M, Giachelli C (2006) Novel insights into vascular calcification. Kidney Int Suppl 105:S5\u2013S9","journal-title":"Kidney Int Suppl"},{"issue":"2","key":"292_CR3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000346161","volume":"50","author":"M Haarhaus","year":"2013","unstructured":"Haarhaus M, Arnqvist HJ, Magnusson P (2013) Calcifying human aortic smooth muscle cells express different bone alkaline phosphatase isoforms, including the novel b1x isoform. J Vasc Res 50(2):167\u2013174","journal-title":"J Vasc Res"},{"issue":"3","key":"292_CR4","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1046\/j.1523-1755.2003.00837.x","volume":"63","author":"MW Taal","year":"2003","unstructured":"Taal MW, Roe S, Masud T, Green D, Porter C, Cassidy MJ (2003) Total hip bone mass predicts survival in chronic hemodialysis patients. Kidney Int 63(3):1116\u20131120","journal-title":"Kidney Int"},{"issue":"2","key":"292_CR5","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/ndt\/gfm660","volume":"23","author":"ND Toussaint","year":"2008","unstructured":"Toussaint ND, Lau KK, Strauss BJ, Polkinghorne KR, Kerr PG (2008) Associations between vascular calcification, arterial stiffness and bone mineral density in chronic kidney disease. Nephrol Dial Transplant 23(2):586\u2013593","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"292_CR6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000126925","volume":"26","author":"K Matsubara","year":"2008","unstructured":"Matsubara K, Suliman ME, Qureshi AR, Axelsson J, Martola L, Heimburger O et al (2008) Bone mineral density in end-stage renal disease patients: association with wasting, cardiovascular disease and mortality. Blood Purif 26(3):284\u2013290","journal-title":"Blood Purif"},{"key":"292_CR7","doi-asserted-by":"crossref","unstructured":"KDIGO (2013) Clinical practice guideline for the evaluation and management of chronic kidney disease. Management of progression and complications of CKD, chapter 3. Kidney Int Suppl 3(1):73\u201390","DOI":"10.1038\/kisup.2012.66"},{"issue":"6","key":"292_CR8","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2796.2006.01640.x","volume":"259","author":"YZ Bagger","year":"2006","unstructured":"Bagger YZ, Tanko LB, Alexandersen P, Qin G, Christiansen C (2006) Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip. J Intern Med 259(6):598\u2013605","journal-title":"J Intern Med"},{"issue":"11","key":"292_CR9","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","volume":"69","author":"S Moe","year":"2006","unstructured":"Moe S, Drueke T, Cunningham J, Goodman W, Martin K, Olgaard K et al (2006) Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease Improving Global Outcomes (KDIGO). Kidney Int 69(11):1945\u20131953","journal-title":"Kidney Int"},{"issue":"2","key":"292_CR10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bone.2012.09.016","volume":"54","author":"T Bellido","year":"2013","unstructured":"Bellido T, Saini V, Pajevic PD (2013) Effects of PTH on osteocyte function. Bone 54(2):250\u2013257","journal-title":"Bone"},{"issue":"4","key":"292_CR11","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0272-6386(95)90599-5","volume":"26","author":"Q Qi","year":"1995","unstructured":"Qi Q, Monier-Faugere MC, Geng Z, Malluche HH (1995) Predictive value of serum parathyroid hormone levels for bone turnover in patients on chronic maintenance dialysis. Am J Kidney Dis 26(4):622\u2013631","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"292_CR12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/0272-6386(95)90453-0","volume":"26","author":"M Wang","year":"1995","unstructured":"Wang M, Hercz G, Sherrard DJ, Maloney NA, Segre GV, Pei Y (1995) Relationship between intact 1\u201384 parathyroid hormone and bone histomorphometric parameters in dialysis patients without aluminum toxicity. Am J Kidney Dis 26(5):836\u2013844","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"292_CR13","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1053\/j.ajkd.2013.02.366","volume":"62","author":"S Sardiwal","year":"2013","unstructured":"Sardiwal S, Magnusson P, Goldsmith DJ, Lamb EJ (2013) Bone alkaline phosphatase in CKD-mineral bone disorder. Am J Kidney Dis Off J Natl Kidney Found 62(4):810\u2013822","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"issue":"2","key":"292_CR14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1359\/jbmr.1997.12.2.210","volume":"12","author":"P Magnusson","year":"1997","unstructured":"Magnusson P, Degerblad M, Saaf M, Larsson L, Thoren M (1997) Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like growth factor-I (IGF-I) and during growth hormone therapy in adults with growth hormone deficiency. J Bone Miner Res 12(2):210\u2013220","journal-title":"J Bone Miner Res"},{"issue":"6","key":"292_CR15","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.clinbiochem.2012.01.018","volume":"45","author":"G Jean","year":"2012","unstructured":"Jean G, Souberbielle JC, Zaoui E, Lorriaux C, Mayor B, Hurot JM et al (2012) Total and bone-specific alkaline phosphatases in haemodialysis patients with chronic liver disease. Clin Biochem 45(6):436\u2013439","journal-title":"Clin Biochem"},{"issue":"1","key":"292_CR16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11255-009-9702-2","volume":"43","author":"C Ambrus","year":"2011","unstructured":"Ambrus C, Almasi C, Berta K, Deak G, Marton A, Molnar MZ et al (2011) Bone mineral density and parathyroid function in patients on maintenance hemodialysis. Int Urol Nephrol 43(1):191\u2013201","journal-title":"Int Urol Nephrol"},{"issue":"6","key":"292_CR17","first-page":"783","volume":"22","author":"A Ferreira","year":"2009","unstructured":"Ferreira A, Saraiva M, Behets G, Macedo A, Galvao M, D\u2019Haese P et al (2009) Evaluation of bone remodeling in hemodialysis patients: serum biochemistry, circulating cytokines and bone histomorphometry. J Nephrol 22(6):783\u2013793","journal-title":"J Nephrol"},{"key":"292_CR18","doi-asserted-by":"crossref","unstructured":"Buchet R, Millan JL, Magne D (2013) Multisystemic functions of alkaline phosphatases. Methods Mol Biol (Clifton, NJ) 1053:27\u201351","DOI":"10.1007\/978-1-62703-562-0_3"},{"issue":"3","key":"292_CR19","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1681\/ASN.V73506","volume":"7","author":"P Urena","year":"1996","unstructured":"Urena P, Hruby M, Ferreira A, Ang KS, de Vernejoul MC (1996) Plasma total versus bone alkaline phosphatase as markers of bone turnover in hemodialysis patients. J Am Soc Nephrol 7(3):506\u2013512","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"292_CR20","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0272-6386(03)00197-5","volume":"41","author":"AR Bervoets","year":"2003","unstructured":"Bervoets AR, Spasovski GB, Behets GJ, Dams G, Polenakovic MH, Zafirovska K et al (2003) Useful biochemical markers for diagnosing renal osteodystrophy in predialysis end-stage renal failure patients. Am J Kidney Dis 41(5):997\u20131007","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"292_CR21","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1046\/j.1523-1755.1999.00422.x","volume":"55","author":"P Stenvinkel","year":"1999","unstructured":"Stenvinkel P, Heimburger O, Paultre F, Diczfalusy U, Wang T, Berglund L et al (1999) Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int 55(5):1899\u20131911","journal-title":"Kidney Int"},{"key":"292_CR22","first-page":"1","volume-title":"Evaluation of precision and accuracy of the lunar iDXA fan-beam densitometer","author":"KGWW Faulkner","year":"1996","unstructured":"Faulkner KGWW, Franz JR, Riewe KP, Barden HS (1996) Evaluation of precision and accuracy of the lunar iDXA fan-beam densitometer. GE Healthcare, Madison, pp 1\u20138"},{"issue":"6","key":"292_CR23","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/ndt\/gfq667","volume":"26","author":"DC Grootendorst","year":"2011","unstructured":"Grootendorst DC, Michels WM, Richardson JD, Jager KJ, Boeschoten EW, Dekker FW et al (2011) The MDRD formula does not reflect GFR in ESRD patients. Nephrol Dial Transplant 26(6):1932\u20131937","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"292_CR24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1542-4758.2009.00430.x","volume":"14","author":"JC Park","year":"2010","unstructured":"Park JC, Kovesdy CP, Duong U, Streja E, Rambod M, Nissenson AR et al (2010) Association of serum alkaline phosphatase and bone mineral density in maintenance hemodialysis patients. Hemodial Int 14(2):182\u2013192","journal-title":"Hemodial Int"},{"issue":"10","key":"292_CR25","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.lfs.2005.02.007","volume":"77","author":"M Ueda","year":"2005","unstructured":"Ueda M, Inaba M, Okuno S, Maeno Y, Ishimura E, Yamakawa T et al (2005) Serum BAP as the clinically useful marker for predicting BMD reduction in diabetic hemodialysis patients with low PTH. Life Sci 77(10):1130\u20131139","journal-title":"Life Sci"},{"key":"292_CR26","doi-asserted-by":"crossref","unstructured":"Nakashima A, Yorioka N, Doi S, Takasugi N, Shigemoto K, Kohno N (2006) Osteoprotegerin and bone mineral density in hemodialysis patients. Osteoporos Int 17(6):841\u2013846","DOI":"10.1007\/s00198-005-0047-0"},{"issue":"4","key":"292_CR27","doi-asserted-by":"crossref","first-page":"c375","DOI":"10.1159\/000323669","volume":"118","author":"A Fujimori","year":"2011","unstructured":"Fujimori A, Okada S, Sakai M, Tome K, Fukagawa M (2011) Relationship between biochemical markers and radial cortical bone changes in hemodialysis patients. Nephron Clin Pract 118(4):c375\u2013c379","journal-title":"Nephron Clin Pract"},{"issue":"8","key":"292_CR28","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","volume":"28","author":"TL Nickolas","year":"2013","unstructured":"Nickolas TL, Stein EM, Dworakowski E, Nishiyama KK, Komandah-Kosseh M, Zhang CA et al (2013) Rapid cortical bone loss in patients with chronic kidney disease. J Bone Miner Res 28(8):1811\u20131820","journal-title":"J Bone Miner Res"},{"issue":"7","key":"292_CR29","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2215\/CJN.09470913","volume":"9","author":"HH Malluche","year":"2014","unstructured":"Malluche HH, Davenport DL, Cantor T, Monier-Faugere MC (2014) Bone mineral density and serum biochemical predictors of bone loss in patients with CKD on dialysis. Clin J Am Soc Nephrol CJASN 9(7):1254\u20131262","journal-title":"Clin J Am Soc Nephrol CJASN"},{"issue":"2","key":"292_CR30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2215\/CJN.09580911","volume":"8","author":"G Garrett","year":"2013","unstructured":"Garrett G, Sardiwal S, Lamb EJ, Goldsmith DJ (2013) PTH\u2014a particularly tricky hormone: why measure it at all in kidney patients? Clin J Am Soc Nephrol CJASN 8(2):299\u2013312","journal-title":"Clin J Am Soc Nephrol CJASN"},{"issue":"7","key":"292_CR31","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.2215\/CJN.10091110","volume":"6","author":"C Drechsler","year":"2011","unstructured":"Drechsler C, Verduijn M, Pilz S, Krediet RT, Dekker FW, Wanner C et al (2011) Bone alkaline phosphatase and mortality in dialysis patients. Clin J Am Soc Nephrol CJASN 6(7):1752\u20131759","journal-title":"Clin J Am Soc Nephrol CJASN"},{"issue":"3","key":"292_CR32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s11255-009-9666-2","volume":"42","author":"C Ambrus","year":"2010","unstructured":"Ambrus C, Marton A, Nemeth ZK, Mucsi I (2010) Bone mineral density in patients on maintenance dialysis. Int Urol Nephrol 42(3):723\u2013739","journal-title":"Int Urol Nephrol"},{"issue":"11","key":"292_CR33","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1681\/ASN.2008010014","volume":"19","author":"DL Regidor","year":"2008","unstructured":"Regidor DL, Kovesdy CP, Mehrotra R, Rambod M, Jing J, McAllister CJ et al (2008) Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patients. J Am Soc Nephrol 19(11):2193\u20132203","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"292_CR34","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/ki.2011.490","volume":"81","author":"DM Spiegel","year":"2012","unstructured":"Spiegel DM, Brady K (2012) Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets. Kidney Int 81(11):1116\u20131122","journal-title":"Kidney Int"},{"issue":"11","key":"292_CR35","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.2215\/CJN.04880512","volume":"7","author":"SA Jamal","year":"2012","unstructured":"Jamal SA, Moe SM (2012) Calcium builds strong bones, and more is better-correct? Well, maybe not. Clin J Am Soc Nephrol CJASN 7(11):1877\u20131883","journal-title":"Clin J Am Soc Nephrol CJASN"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-016-0292-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40620-016-0292-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-016-0292-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-016-0292-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:57:15Z","timestamp":1777564635000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/30\/2\/255\/8371341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,18]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["292"],"URL":"https:\/\/doi.org\/10.1007\/s40620-016-0292-7","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,18]]}}}