{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:46:34Z","timestamp":1791647194947,"version":"4.3.4"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2013-02356802"],"award-info":[{"award-number":["RF-2013-02356802"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2011-02351840"],"award-info":[{"award-number":["RF-2011-02351840"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001296","name":"PKD Foundation","doi-asserted-by":"publisher","award":["187G14a\/b"],"award-info":[{"award-number":["187G14a\/b"]}],"id":[{"id":"10.13039\/100001296","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s40620-017-0395-9","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T04:19:02Z","timestamp":1491538742000},"page":"511-519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Defective glycolysis and the use of 2-deoxy-d-glucose in polycystic kidney disease: from animal models to humans"],"prefix":"10.1093","volume":"30","author":[{"given":"Riccardo","family":"Magistroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-4006","authenticated-orcid":false,"given":"Alessandra","family":"Boletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"issue":"Suppl 4","key":"395_CR1","doi-asserted-by":"publisher","first-page":"iv15","DOI":"10.1093\/ndt\/gfu017","volume":"29","author":"EM Spithoven","year":"2014","unstructured":"Spithoven EM, Kramer A, Meijer E, Orskov B, Wanner C, Abad JM, Areste N, de la Torre RA, Caskey F, Couchoud C, Finne P, Heaf J, Hoitsma A, de Meester J, Pascual J, Postorino M, Ravani P, Zurriaga O, Jager KJ, Gansevoort RT, Registry E-E, Euro CC, Wgikd (2014) Renal replacement therapy for autosomal dominant polycystic kidney disease (ADPKD) in Europe: prevalence and survival\u2014an analysis of data from the ERA-EDTA Registry. Nephrol Dial Transplant 29(Suppl 4):iv15\u2013i25. doi: 10.1093\/ndt\/gfu017","journal-title":"Nephrol Dial Transplant"},{"key":"395_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw240","author":"CJ Willey","year":"2016","unstructured":"Willey CJ, Blais JD, Hall AK, Krasa HB, Makin AJ, Czerwiec FS (2016) Prevalence of autosomal dominant polycystic kidney disease in the European Union. Nephrol Dial Transplant. doi: 10.1093\/ndt\/gfw240","journal-title":"Nephrol Dial Transplant"},{"issue":"9981","key":"395_CR3","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/S0140-6736(15)60907-2","volume":"385","author":"AC Ong","year":"2015","unstructured":"Ong AC, Devuyst O, Knebelmann B, Walz G, Diseases E-EWGfIK (2015) Autosomal dominant polycystic kidney disease: the changing face of clinical management. Lancet 385(9981):1993\u20132002. doi: 10.1016\/S0140-6736(15)60907-2","journal-title":"Lancet"},{"issue":"14","key":"395_CR4","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1056\/NEJMcp0804458","volume":"359","author":"JJ Grantham","year":"2008","unstructured":"Grantham JJ (2008) Clinical practice. Autosomal dominant polycystic kidney disease. N Engl J Med 359(14):1477\u20131485. doi: 10.1056\/NEJMcp0804458","journal-title":"N Engl J Med"},{"key":"395_CR5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000421651","volume":"97","author":"DJ Peters","year":"1992","unstructured":"Peters DJ, Sandkuijl LA (1992) Genetic heterogeneity of polycystic kidney disease in Europe. Contrib Nephrol 97:128\u2013139","journal-title":"Contrib Nephrol"},{"issue":"6","key":"395_CR6","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1681\/ASN.2012070650","volume":"24","author":"E Cornec-Le Gall","year":"2013","unstructured":"Cornec-Le Gall E, Audrezet MP, Chen JM, Hourmant M, Morin MP, Perrichot R, Charasse C, Whebe B, Renaudineau E, Jousset P, Guillodo MP, Grall-Jezequel A, Saliou P, Ferec C, Le Meur Y (2013) Type of PKD1 mutation influences renal outcome in ADPKD. J Am Soc Nephrol 24(6):1006\u20131013. doi: 10.1681\/ASN.2012070650","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"395_CR7","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJMoa0907419","volume":"363","author":"AL Serra","year":"2010","unstructured":"Serra AL, Poster D, Kistler AD, Krauer F, Raina S, Young J, Rentsch KM, Spanaus KS, Senn O, Kristanto P, Scheffel H, Weishaupt D, Wuthrich RP (2010) Sirolimus and kidney growth in autosomal dominant polycystic kidney disease. N Engl J Med 363(9):820\u2013829 pii]10.1056\/NEJMoa0907419","journal-title":"N Engl J Med"},{"issue":"9","key":"395_CR8","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1056\/NEJMoa1003491","volume":"363","author":"G Walz","year":"2010","unstructured":"Walz G, Budde K, Mannaa M, Nurnberger J, Wanner C, Sommerer C, Kunzendorf U, Banas B, Horl WH, Obermuller N, Arns W, Pavenstadt H, Gaedeke J, Buchert M, May C, Gschaidmeier H, Kramer S, Eckardt KU (2010) Everolimus in patients with autosomal dominant polycystic kidney disease. N Engl J Med 363(9):830\u2013840. doi: 10.1056\/NEJMoa1003491","journal-title":"N Engl J Med"},{"key":"395_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-016-0358-6","author":"IA Iliuta","year":"2016","unstructured":"Iliuta IA, Kitchlu A, Pei Y (2016) Methodological issues in clinical trials of polycystic kidney disease: a focused review. J Nephrol. doi: 10.1007\/s40620-016-0358-6","journal-title":"J Nephrol"},{"key":"395_CR10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205511","author":"VE Torres","year":"2012","unstructured":"Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Grantham JJ, Higashihara E, Perrone RD, Krasa HB, Ouyang J, Czerwiec FS (2012) Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med. doi: 10.1056\/NEJMoa1205511","journal-title":"N Engl J Med"},{"issue":"34","key":"395_CR11","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1038\/sj.onc.1209597","volume":"25","author":"H Pelicano","year":"2006","unstructured":"Pelicano H, Martin DS, Xu RH, Huang P (2006) Glycolysis inhibition for anticancer treatment. Oncogene 25(34):4633\u20134646. doi: 10.1038\/sj.onc.1209597","journal-title":"Oncogene"},{"issue":"5930","key":"395_CR12","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324(5930):1029\u20131033. doi: 10.1126\/science.1160809","journal-title":"Science"},{"issue":"11","key":"395_CR13","doi-asserted-by":"publisher","first-page":"e1003053","DOI":"10.1371\/journal.pgen.1003053","volume":"8","author":"LF Menezes","year":"2012","unstructured":"Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG (2012) Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4alpha as a disease modifier. PLoS Genet 8(11):e1003053. doi: 10.1371\/journal.pgen.1003053","journal-title":"PLoS Genet"},{"issue":"4","key":"395_CR14","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nm.3092","volume":"19","author":"I Rowe","year":"2013","unstructured":"Rowe I, Chiaravalli M, Mannella V, Ulisse V, Quilici G, Pema M, Song XW, Xu H, Mari S, Qian F, Pei Y, Musco G, Boletta A (2013) Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Nat Med 19(4):488\u2013493. doi: 10.1038\/nm.3092","journal-title":"Nat Med"},{"issue":"8","key":"395_CR15","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1093\/ndt\/gft521","volume":"29","author":"I Rowe","year":"2014","unstructured":"Rowe I, Boletta A (2014) Defective metabolism in polycystic kidney disease: potential for therapy and open questions. Nephrol Dial Transplant 29(8):1480\u20131486. doi: 10.1093\/ndt\/gft521","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"395_CR16","doi-asserted-by":"publisher","first-page":"e0146654","DOI":"10.1371\/journal.pone.0146654","volume":"11","author":"M Riwanto","year":"2016","unstructured":"Riwanto M, Kapoor S, Rodriguez D, Edenhofer I, Segerer S, Wuthrich RP (2016) Inhibition of aerobic glycolysis attenuates disease progression in polycystic kidney disease. PLoS One 11(1):e0146654. doi: 10.1371\/journal.pone.0146654","journal-title":"PLoS One"},{"key":"395_CR17","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00238.2015","author":"VJ Hwang","year":"2015","unstructured":"Hwang VJ, Kim J, Rand A, Yang C, Sturdivant S, Hammock B, Bell PD, Guay-Woodford LM, Weiss RH (2015) The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. Am J Physiol Renal Physiol 309 (6):F492-498. doi: 10.1152\/ajprenal.00238.2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"395_CR18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030231","author":"M Chiaravalli","year":"2015","unstructured":"Chiaravalli M, Rowe I, Mannella V, Quilici G, Canu T, Bianchi V, Gurgone A, Antunes S, D\u2019Adamo P, Esposito A, Musco G, Boletta A (2015) 2-Deoxy-d-glucose ameliorates PKD progression. J Am Soc Nephrol. doi: 10.1681\/ASN.2015030231","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"395_CR19","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1172\/JCI80467","volume":"125","author":"L Chen","year":"2015","unstructured":"Chen L, Zhou X, Fan LX, Yao Y, Swenson-Fields KI, Gadjeva M, Wallace DP, Peters DJ, Yu A, Grantham JJ, Li X (2015) Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest 125(6):2399\u20132412. doi: 10.1172\/JCI80467","journal-title":"J Clin Invest"},{"issue":"5","key":"395_CR20","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1681\/ASN.2015020132","volume":"27","author":"G Warner","year":"2016","unstructured":"Warner G, Hein KZ, Nin V, Edwards M, Chini CC, Hopp K, Harris PC, Torres VE, Chini EN (2016) Food restriction ameliorates the development of polycystic kidney disease. J Am Soc Nephrol 27(5):1437\u20131447. doi: 10.1681\/ASN.2015020132","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"395_CR21","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.transproceed.2009.01.069","volume":"41","author":"S Goncalves","year":"2009","unstructured":"Goncalves S, Guerra J, Santana A, Abreu F, Mil-Homens C, Gomes da Costa A (2009) Autosomal-dominant polycystic kidney disease and kidney transplantation: experience of a single center. Transplant Proc 41(3):887\u2013890. doi: 10.1016\/j.transproceed.2009.01.069","journal-title":"Transplant Proc"},{"issue":"2","key":"395_CR22","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/j.1523-1755.2005.67132.x","volume":"67","author":"AM Mattos de","year":"2005","unstructured":"de Mattos AM, Olyaei AJ, Prather JC, Golconda MS, Barry JM, Norman DJ (2005) Autosomal-dominant polycystic kidney disease as a risk factor for diabetes mellitus following renal transplantation. Kidney Int 67(2):714\u2013720. doi: 10.1111\/j.1523-1755.2005.67132.x","journal-title":"Kidney Int"},{"issue":"7","key":"395_CR23","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1097\/TP.0b013e31820f0877","volume":"91","author":"S Caillard","year":"2011","unstructured":"Caillard S, Eprinchard L, Perrin P, Braun L, Heibel F, Moreau F, Kessler L, Moulin B (2011) Incidence and risk factors of glucose metabolism disorders in kidney transplant recipients: role of systematic screening by oral glucose tolerance test. Transplantation 91(7):757\u2013764. doi: 10.1097\/TP.0b013e31820f0877","journal-title":"Transplantation"},{"issue":"5","key":"395_CR24","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/ndt\/17.5.887","volume":"17","author":"MA Gentil","year":"2002","unstructured":"Gentil MA, Luna E, Rodriguez-Algarra G, Osuna A, Gonzalez-Molina M, Mazuecos A, Cubero JJ, Del Castillo D (2002) Incidence of diabetes mellitus requiring insulin treatment after renal transplantation in patients with hepatitis C. Nephrol Dial Transplant 17(5):887\u2013891","journal-title":"Nephrol Dial Transplant"},{"key":"395_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2147\/DMSO.S19027","volume":"4","author":"PT Pham","year":"2011","unstructured":"Pham PT, Pham PM, Pham SV, Pham PA, Pham PC (2011) New onset diabetes after transplantation (NODAT): an overview. Diabetes Metab Syndr Obes 4:175\u2013186. doi: 10.2147\/DMSO.S19027","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"3","key":"395_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijt.2012.07.003","volume":"6","author":"J Prakash","year":"2012","unstructured":"Prakash J, Rathore SS, Brojen Singh T, Choudhury TA, Prabhakar, Usha (2012) New onset diabetes after transplantation (NODAT): analysis of pre-transplant risk factors in renal allograft recipients. Indian J Transplant 6(3):77\u201382. doi: 10.1016\/j.ijt.2012.07.003","journal-title":"Indian J Transplant"},{"issue":"5","key":"395_CR27","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/ndt\/14.5.1244","volume":"14","author":"D Ducloux","year":"1999","unstructured":"Ducloux D, Motte G, Vautrin P, Bresson-Vautrin C, Rebibou JM, Chalopin JM (1999) Polycystic kidney disease as a risk factor for post-transplant diabetes mellitus. Nephrol Dial Transplant 14(5):1244\u20131246","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"395_CR28","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/01.tp.0000248759.37146.3d","volume":"83","author":"RA Hamer","year":"2007","unstructured":"Hamer RA, Chow CL, Ong AC, McKane WS (2007) Polycystic kidney disease is a risk factor for new-onset diabetes after transplantation. Transplantation 83(1):36\u201340. doi: 10.1097\/01.tp.0000248759.37146.3d","journal-title":"Transplantation"},{"issue":"6","key":"395_CR29","first-page":"1038","volume":"21","author":"E Razeghi","year":"2010","unstructured":"Razeghi E, Heydarian P, Amerian M, Pourmand G (2010) The risk factors for diabetes mellitus after kidney transplantation. Saudi J Kidney Dis Transpl 21(6):1038\u20131043","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"3","key":"395_CR30","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.arcmed.2007.10.003","volume":"39","author":"M Pietrzak-Nowacka","year":"2008","unstructured":"Pietrzak-Nowacka M, Safranow K, Rozanski J, Debska-Slizien A, Domanski L, Dziewanowski K, Glyda M, Jankowska M, Nocen M, Pabisiak K, Rutkowski B, Wisniewska M, Ciechanowski K (2008) Autosomal dominant polycystic kidney disease is not a risk factor for post-transplant diabetes mellitus. Matched-pair design multicenter study. Arch Med Res 39(3):312\u2013319. doi: 10.1016\/j.arcmed.2007.10.003","journal-title":"Arch Med Res"},{"issue":"5","key":"395_CR31","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1111\/j.1399-0012.2010.01367.x","volume":"25","author":"C Courivaud","year":"2011","unstructured":"Courivaud C, Ladriere M, Toupance O, Caillard S, Hurault de Ligny B, Ryckelynck JP, Moulin B, Rieu P, Frimat L, Chalopin JM, Chauve S, Kazory A, Ducloux D (2011) Impact of pre-transplant dialysis modality on post-transplant diabetes mellitus after kidney transplantation. Clin Transplant 25(5):794\u2013799. doi: 10.1111\/j.1399-0012.2010.01367.x","journal-title":"Clin Transplant"},{"issue":"10","key":"395_CR32","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1093\/ndt\/14.10.2521","volume":"14","author":"J Hjelmesaeth","year":"1999","unstructured":"Hjelmesaeth J, Hartmann A (1999) Insulin resistance in patients with adult polycystic kidney disease. Nephrol Dial Transplant 14(10):2521\u20132522","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"395_CR33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1440-1797.2011.01507.x","volume":"17","author":"I Ruderman","year":"2012","unstructured":"Ruderman I, Masterson R, Yates C, Gorelik A, Cohney SJ, Walker RG (2012) New onset diabetes after kidney transplantation in autosomal dominant polycystic kidney disease: a retrospective cohort study. Nephrology (Carlton) 17 (1):89\u201396. doi: 10.1111\/j.1440-1797.2011.01507.x","journal-title":"Nephrology (Carlton)"},{"issue":"1","key":"395_CR34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.2337\/dc11-1230","volume":"35","author":"L Ghisdal","year":"2012","unstructured":"Ghisdal L, Van Laecke S, Abramowicz MJ, Vanholder R, Abramowicz D (2012) New-onset diabetes after renal transplantation: risk assessment and management. Diabetes Care 35(1):181\u2013188. doi: 10.2337\/dc11-1230","journal-title":"Diabetes Care"},{"issue":"6","key":"395_CR35","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.1432-2277.2011.01237.x","volume":"24","author":"A Jacquet","year":"2011","unstructured":"Jacquet A, Pallet N, Kessler M, Hourmant M, Garrigue V, Rostaing L, Kreis H, Legendre C, Mamzer-Bruneel MF (2011) Outcomes of renal transplantation in patients with autosomal dominant polycystic kidney disease: a nationwide longitudinal study. Transpl Int 24(6):582\u2013587. doi: 10.1111\/j.1432-2277.2011.01237.x","journal-title":"Transpl Int"},{"key":"395_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2016.03.001","author":"W Cheungpasitporn","year":"2016","unstructured":"Cheungpasitporn W, Thongprayoon C, Vijayvargiya P, Anthanont P, Erickson SB (2016) The risk for new-onset diabetes mellitus after kidney transplantation in patients with autosomal dominant polycystic kidney disease: a systematic review and meta-analysis. Can J Diabetes. doi: 10.1016\/j.jcjd.2016.03.001","journal-title":"Can J Diabetes"},{"issue":"8","key":"395_CR37","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3109\/00365513.2010.527012","volume":"70","author":"M Pietrzak-Nowacka","year":"2010","unstructured":"Pietrzak-Nowacka M, Safranow K, Byra E, Nowosiad M, Marchelek-Mysliwiec M, Ciechanowski K (2010) Glucose metabolism parameters during an oral glucose tolerance test in patients with autosomal dominant polycystic kidney disease. Scand J Clin Lab Invest 70(8):561\u2013567. doi: 10.3109\/00365513.2010.527012","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"395_CR38","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2215\/CJN.04140510","volume":"6","author":"V Menon","year":"2011","unstructured":"Menon V, Rudym D, Chandra P, Miskulin D, Perrone R, Sarnak M (2011) Inflammation, oxidative stress, and insulin resistance in polycystic kidney disease. Clin J Am Soc Nephrol 6(1):7\u201313. doi: 10.2215\/CJN.04140510","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"395_CR39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ki.1997.360","volume":"52","author":"K Vareesangthip","year":"1997","unstructured":"Vareesangthip K, Tong P, Wilkinson R, Thomas TH (1997) Insulin resistance in adult polycystic kidney disease. Kidney Int 52(2):503\u2013508","journal-title":"Kidney Int"},{"issue":"7","key":"395_CR40","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1093\/ndt\/gfr744","volume":"27","author":"B Reed","year":"2012","unstructured":"Reed B, Helal I, McFann K, Wang W, Yan XD, Schrier RW (2012) The impact of type II diabetes mellitus in patients with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant 27(7):2862\u20132865. doi: 10.1093\/ndt\/gfr744","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"395_CR41","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.molcel.2010.06.022","volume":"39","author":"K Duvel","year":"2010","unstructured":"Duvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, Manning BD (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 39(2):171\u2013183. doi: 10.1016\/j.molcel.2010.06.022","journal-title":"Mol Cell"},{"issue":"1","key":"395_CR42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.gde.2009.10.009","volume":"20","author":"GL Semenza","year":"2010","unstructured":"Semenza GL (2010) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20(1):51\u201356. doi: 10.1016\/j.gde.2009.10.009","journal-title":"Curr Opin Genet Dev"},{"issue":"3","key":"395_CR43","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.eplepsyres.2012.04.012","volume":"101","author":"JC Ockuly","year":"2012","unstructured":"Ockuly JC, Gielissen JM, Levenick CV, Zeal C, Groble K, Munsey K, Sutula TP, Stafstrom CE (2012) Behavioral, cognitive, and safety profile of 2-deoxy-2-glucose (2DG) in adult rats. Epilepsy Res 101(3):246\u2013252. doi: 10.1016\/j.eplepsyres.2012.04.012","journal-title":"Epilepsy Res"},{"issue":"Suppl 8","key":"395_CR44","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1528-1167.2008.01848.x","volume":"49","author":"CE Stafstrom","year":"2008","unstructured":"Stafstrom CE, Roopra A, Sutula TP (2008) Seizure suppression via glycolysis inhibition with 2-deoxy-d-glucose (2DG). Epilepsia 49(Suppl 8):97\u2013100. doi: 10.1111\/j.1528-1167.2008.01848.x","journal-title":"Epilepsia"},{"issue":"3","key":"395_CR45","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.taap.2009.11.025","volume":"243","author":"RK Minor","year":"2010","unstructured":"Minor RK, Smith DL Jr, Sossong AM, Kaushik S, Poosala S, Spangler EL, Roth GS, Lane M, Allison DB, de Cabo R, Ingram DK, Mattison JA (2010) Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats. Toxicol Appl Pharmacol 243(3):332\u2013339. doi: 10.1016\/j.taap.2009.11.025","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"395_CR46","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"AB Nair","year":"2016","unstructured":"Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7(2):27\u201331. doi: 10.4103\/0976-0105.177703","journal-title":"J Basic Clin Pharm"},{"issue":"2","key":"395_CR47","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00280-012-2045-1","volume":"71","author":"LE Raez","year":"2013","unstructured":"Raez LE, Papadopoulos K, Ricart AD, Chiorean EG, Dipaola RS, Stein MN, Rocha Lima CM, Schlesselman JJ, Tolba K, Langmuir VK, Kroll S, Jung DT, Kurtoglu M, Rosenblatt J, Lampidis TJ (2013) A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol 71(2):523\u2013530. doi: 10.1007\/s00280-012-2045-1","journal-title":"Cancer Chemother Pharmacol"},{"issue":"13","key":"395_CR48","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1002\/pros.21172","volume":"70","author":"M Stein","year":"2010","unstructured":"Stein M, Lin H, Jeyamohan C, Dvorzhinski D, Gounder M, Bray K, Eddy S, Goodin S, White E, Dipaola RS (2010) Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies. Prostate 70(13):1388\u20131394. doi: 10.1002\/pros.21172","journal-title":"Prostate"},{"issue":"8","key":"395_CR49","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00066-005-1320-z","volume":"181","author":"D Singh","year":"2005","unstructured":"Singh D, Banerji AK, Dwarakanath BS, Tripathi RP, Gupta JP, Mathew TL, Ravindranath T, Jain V (2005) Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther Onkol 181(8):507\u2013514. doi: 10.1007\/s00066-005-1320-z","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"395_CR50","first-page":"485","volume":"21","author":"BR Landau","year":"1958","unstructured":"Landau BR, Laszlo J, Stengle J, Burk D (1958) Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-d-glucose. J Natl Cancer Inst 21(3):485\u2013494","journal-title":"J Natl Cancer Inst"},{"issue":"4656","key":"395_CR51","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/183271b0","volume":"183","author":"ED Kilbourne","year":"1959","unstructured":"Kilbourne ED (1959) Inhibition of influenza virus multiplication with a glucose antimetabolite (2-deoxy-d-glucose). Nature 183(4656):271\u2013272","journal-title":"Nature"},{"issue":"2","key":"395_CR52","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0042-6822(73)90340-1","volume":"52","author":"RJ Courtney","year":"1973","unstructured":"Courtney RJ, Steiner SM, Benyesh-Melnick M (1973) Effects of 2-deoxy-d-glucose on herpes simplex virus replication. Virology 52(2):447\u2013455","journal-title":"Virology"},{"issue":"11","key":"395_CR53","doi-asserted-by":"publisher","first-page":"5794","DOI":"10.1128\/AAC.01126-12","volume":"56","author":"HJ Leung","year":"2012","unstructured":"Leung HJ, Duran EM, Kurtoglu M, Andreansky S, Lampidis TJ, Mesri EA (2012) Activation of the unfolded protein response by 2-deoxy-d-glucose inhibits Kaposi\u2019s sarcoma-associated herpesvirus replication and gene expression. Antimicrob Agents Chemother 56(11):5794\u20135803. doi: 10.1128\/AAC.01126-12","journal-title":"Antimicrob Agents Chemother"},{"key":"395_CR54","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.virol.2015.02.038","volume":"479\u2013480","author":"EL Sanchez","year":"2015","unstructured":"Sanchez EL, Lagunoff M (2015) Viral activation of cellular metabolism. Virology 479\u2013480:609\u2013618. doi: 10.1016\/j.virol.2015.02.038","journal-title":"Virology"},{"issue":"4","key":"395_CR55","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/jemt.10214","volume":"59","author":"MA Lane","year":"2002","unstructured":"Lane MA, Mattison J, Ingram DK, Roth GS (2002) Caloric restriction and aging in primates: relevance to humans and possible CR mimetics. Microsc Res Tech 59(4):335\u2013338. doi: 10.1002\/jemt.10214","journal-title":"Microsc Res Tech"},{"issue":"4","key":"395_CR56","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.cmet.2007.08.011","volume":"6","author":"TJ Schulz","year":"2007","unstructured":"Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M (2007) Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 6(4):280\u2013293. doi: 10.1016\/j.cmet.2007.08.011","journal-title":"Cell Metab"},{"issue":"3","key":"395_CR57","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.bbrc.2015.02.145","volume":"459","author":"Q Che","year":"2015","unstructured":"Che Q, Lin L, Ai Q, Ge P, Dai J, Jiang R, Zhou D, Wan J, Zhang L (2015) Caloric restriction mimetic 2-deoxyglucose alleviated lethal liver injury induced by lipopolysaccharide\/d-galactosamine in mice. Biochem Biophys Res Commun 459(3):541\u2013546. doi: 10.1016\/j.bbrc.2015.02.145","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"395_CR58","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/(SICI)1097-4547(19990701)57:1<48::AID-JNR6>3.0.CO;2-L","volume":"57","author":"J Lee","year":"1999","unstructured":"Lee J, Bruce-Keller AJ, Kruman Y, Chan SL, Mattson MP (1999) 2-Deoxy-d-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins. J Neurosci Res 57(1):48\u201361","journal-title":"J Neurosci Res"},{"issue":"2","key":"395_CR59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/(SICI)1097-4547(19990715)57:2<195::AID-JNR5>3.0.CO;2-P","volume":"57","author":"W Duan","year":"1999","unstructured":"Duan W, Mattson MP (1999) Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson\u2019s disease. J Neurosci Res 57(2):195\u2013206","journal-title":"J Neurosci Res"},{"issue":"2","key":"395_CR60","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.canlet.2014.09.003","volume":"355","author":"D Zhang","year":"2014","unstructured":"Zhang D, Li J, Wang F, Hu J, Wang S, Sun Y (2014) 2-Deoxy-d-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett 355(2):176\u2013183. doi: 10.1016\/j.canlet.2014.09.003","journal-title":"Cancer Lett"},{"issue":"6","key":"395_CR61","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1097\/COC.0b013e3181e84dec","volume":"34","author":"BM Madhok","year":"2011","unstructured":"Madhok BM, Yeluri S, Perry SL, Hughes TA, Jayne DG (2011) Targeting glucose metabolism: an emerging concept for anticancer therapy. Am J Clin Oncol 34(6):628\u2013635. doi: 10.1097\/COC.0b013e3181e84dec","journal-title":"Am J Clin Oncol"},{"issue":"5","key":"395_CR62","doi-asserted-by":"publisher","first-page":"581","DOI":"10.2217\/fon.09.44","volume":"5","author":"B Dwarakanath","year":"2009","unstructured":"Dwarakanath B, Jain V (2009) Targeting glucose metabolism with 2-deoxy-d-glucose for improving cancer therapy. Future Oncol 5(5):581\u2013585. doi: 10.2217\/fon.09.44","journal-title":"Future Oncol"},{"issue":"Suppl 1","key":"395_CR63","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.4103\/0973-1482.55138","volume":"5","author":"A Farooque","year":"2009","unstructured":"Farooque A, Afrin F, Adhikari JS, Dwarakanath BS (2009) Protection of normal cells and tissues during radio- and chemosensitization of tumors by 2-deoxy-d-glucose. J Cancer Res Ther 5(Suppl 1):S32\u2013S35. doi: 10.4103\/0973-1482.55138","journal-title":"J Cancer Res Ther"},{"issue":"1","key":"395_CR64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000197647","volume":"12","author":"D Burckhardt","year":"1975","unstructured":"Burckhardt D, Stalder GA (1975) Cardiac changes during 2-deoxy-d-glucose test. A study in patients with selective vagotomy and pyloroplasty. Digestion 12(1):1\u20138","journal-title":"Digestion"},{"issue":"4","key":"395_CR65","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0016-5085(19)33237-8","volume":"63","author":"GA Stalder","year":"1972","unstructured":"Stalder GA, Schultheiss HR, Allgower M (1972) Use of 2-deoxy-d-glucose for testing completeness of vagotomy in man. Gastroenterology 63(4):552\u2013556","journal-title":"Gastroenterology"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40620-017-0395-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-017-0395-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-017-0395-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:57:17Z","timestamp":1777564637000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/30\/4\/511\/8371350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,7]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["395"],"URL":"https:\/\/doi.org\/10.1007\/s40620-017-0395-9","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,7]]}}}