{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:21:55Z","timestamp":1778275315766,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Curie Research Program"},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Danish Council for Independent Research\u2014Medical Sciences"},{"name":"Aarhus University Research Foundation and AU-center: MEMBRANES"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s40620-017-0460-4","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T02:50:28Z","timestamp":1511491828000},"page":"385-393","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lithium increases ammonium excretion leading to altered urinary acid-base buffer composition"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0622-6612","authenticated-orcid":false,"given":"Francesco","family":"Trepiccione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Altobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovambattista","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte M\u00f8nster","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Frische","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"460_CR1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ki.1982.49","volume":"21","author":"D Batlle","year":"1982","unstructured":"Batlle D, Gaviria M, Grupp M, Arruda JA, Wynn J, Kurtzman NA (1982) Distal nephron function in patients receiving chronic lithium therapy. Kidney Int 21:477\u2013485","journal-title":"Kidney Int"},{"issue":"Suppl 16","key":"460_CR2","first-page":"S57","volume":"23","author":"SL Alper","year":"2010","unstructured":"Alper SL (2010) Familial renal tubular acidosis. J Nephrol 23(Suppl 16):S57\u2013S76 (review)","journal-title":"J Nephrol"},{"key":"460_CR3","first-page":"F515","volume":"239","author":"JA Arruda","year":"1980","unstructured":"Arruda JA, Kurtzman NA (1980) Mechanisms and classification of deranged distal urinary acidification. Am J Physiol 239:F515\u2013F523","journal-title":"Am J Physiol"},{"key":"460_CR4","first-page":"305","volume":"48","author":"JN Galla","year":"1975","unstructured":"Galla JN, Forrest JN, Hecht B, Kashgarian M, Hayslett JP (1975) Effect of lithium on water and electrolyte metabolism. Yale J Biol Med 48:305\u2013314","journal-title":"Yale J Biol Med"},{"key":"460_CR5","doi-asserted-by":"crossref","first-page":"F1244","DOI":"10.1152\/ajprenal.00176.2003","volume":"285","author":"YH Kim","year":"2003","unstructured":"Kim YH, Kwon TH, Christensen BM, Nielsen J, Wall SM, Madsen KM, Frokiaer J, Nielsen S (2003) Altered expression of renal acid-base transporters in rats with lithium-induced NDI. Am J Physiol Renal Physiol 285:F1244\u2013F1257","journal-title":"Am J Physiol Renal Physiol"},{"key":"460_CR6","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1172\/JCI111805","volume":"75","author":"TD DuBose Jr","year":"1985","unstructured":"DuBose TD Jr, Caflisch CR (1985) Validation of the difference in urine and blood carbon dioxide tension during bicarbonate loading as an index of distal nephron acidification in experimental models of distal renal tubular acidosis. J Clin Invest 75:1116\u20131123","journal-title":"J Clin Invest"},{"issue":"Suppl 16","key":"460_CR7","first-page":"S43","volume":"23","author":"F Trepiccione","year":"2010","unstructured":"Trepiccione F, Christensen BM (2010) Lithium-induced nephrogenic diabetes insipidus: new clinical and experimental findings. J Nephrol 23(Suppl 16):S43\u2013S48 (review)","journal-title":"J Nephrol"},{"issue":"4","key":"460_CR8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/ki.2014.107","volume":"86","author":"F Trepiccione","year":"2014","unstructured":"Trepiccione F, Pisitkun T, Hoffert JD, Poulsen SB, Capasso G, Nielsen S, Knepper MA, Fenton RA, Christensen BM (2014) Early targets of lithium in rat kidney inner medullary collecting duct include p38 and ERK1\/2. Kidney Int 86(4):757\u2013767","journal-title":"Kidney Int"},{"key":"460_CR9","doi-asserted-by":"crossref","first-page":"F39","DOI":"10.1152\/ajprenal.00383.2005","volume":"291","author":"BM Christensen","year":"2006","unstructured":"Christensen BM, Kim YH, Kwon TH, Nielsen S (2006) Lithium treatment induces a marked proliferation of primarily principal cells in rat kidney inner medullary collecting duct. Am J Physiol Renal Physiol 291:F39\u2013F48","journal-title":"Am J Physiol Renal Physiol"},{"key":"460_CR10","doi-asserted-by":"crossref","first-page":"C952","DOI":"10.1152\/ajpcell.00266.2003","volume":"286","author":"BM Christensen","year":"2004","unstructured":"Christensen BM, Marples D, Kim YH, Wang W, Frokiaer J, Nielsen S (2004) Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI. Am J Physiol Cell Physiol 286:C952\u2013C964","journal-title":"Am J Physiol Cell Physiol"},{"key":"460_CR11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1681\/ASN.2010070734","volume":"22","author":"BM Christensen","year":"2011","unstructured":"Christensen BM, Zuber AM, Loffing J, Stehle JC, Deen PM, Rossier BC, Hummler E (2011) alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus. J Am Soc Nephrol 22:253\u2013261","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"460_CR12","doi-asserted-by":"crossref","first-page":"F919","DOI":"10.1152\/ajprenal.00152.2012","volume":"305","author":"F Trepiccione","year":"2013","unstructured":"Trepiccione F, Capasso G, Nielsen S, Christensen BM (2013) Evaluation of cellular plasticity in the collecting duct during recovery from lithium-induced nephrogenic diabetes insipidus. Am J Physiol Renal Physiol 305(6):F919\u2013F929","journal-title":"Am J Physiol Renal Physiol"},{"key":"460_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-017-1997-8","author":"F Trepiccione","year":"2017","unstructured":"Trepiccione F, Iena FM, Catalini L, Carpi FM, Koed M, Frische S (2017) Measurement of total CO2 in microliter samples of urine and other biological fluids using infrared detection of CO2. Pflugers Arch. \nhttps:\/\/doi.org\/10.1007\/s00424-017-1997-8","journal-title":"Pflugers Arch"},{"issue":"1","key":"460_CR14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1681\/ASN.2015070734","volume":"28","author":"A Sinning","year":"2017","unstructured":"Sinning A, Radionov N, Trepiccione F, L\u00f3pez-Cayuqueo KI, Jayat M, Baron S, Corni\u00e8re N, Alexander RT, Hadchouel J, Eladari D, H\u00fcbner CA (2017) Chambrey R double knockout of the Na+-driven Cl-\/HCO3-exchanger and Na+\/Cl- cotransporter induces hypokalemia and volume depletion. J Am Soc Nephrol 28(1):130\u2013139","journal-title":"J Am Soc Nephrol"},{"key":"460_CR15","doi-asserted-by":"crossref","first-page":"H172","DOI":"10.1152\/ajpheart.00713.2005","volume":"290","author":"HH Damkier","year":"2006","unstructured":"Damkier HH, Nielsen S, Praetorius J (2006) An anti-NH2-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 290:H172\u2013H180","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"460_CR16","doi-asserted-by":"crossref","first-page":"F1163","DOI":"10.1152\/ajprenal.00409.2003","volume":"286","author":"S Frische","year":"2004","unstructured":"Frische S, Zolotarev AS, Kim YH, Praetorius J, Alper S, Nielsen S, Wall SM (2004) AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading. Am J Physiol Renal Physiol 286:F1163\u2013F1170","journal-title":"Am J Physiol Renal Physiol"},{"key":"460_CR17","doi-asserted-by":"crossref","first-page":"F744","DOI":"10.1152\/ajprenal.00037.2002","volume":"283","author":"YH Kim","year":"2002","unstructured":"Kim YH, Kwon TH, Frische S, Kim J, Tisher CC, Madsen KM, Nielsen S (2002) Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney. Am J Physiol Renal Physiol 283:F744\u2013F754","journal-title":"Am J Physiol Renal Physiol"},{"key":"460_CR18","doi-asserted-by":"crossref","first-page":"F1198","DOI":"10.1152\/ajprenal.00118.2003","volume":"285","author":"J Nielsen","year":"2003","unstructured":"Nielsen J, Kwon TH, Praetorius J, Kim YH, Frokiaer J, Knepper MA, Nielsen S (2003) Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI. Am J Physiol Renal Physiol 285:F1198\u2013F1209","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"460_CR19","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s11906-015-0538-0","volume":"17","author":"R Chambrey","year":"2015","unstructured":"Chambrey R, Trepiccione F (2015) Relative roles of principal and intercalated cells in the regulation of sodium balance and blood pressure. Curr Hypertens Rep 17(4):538","journal-title":"Curr Hypertens Rep"},{"issue":"Suppl 16","key":"460_CR20","first-page":"S35","volume":"23","author":"J Praetorius","year":"2010","unstructured":"Praetorius J (2010) Na+-coupled bicarbonate transporters in duodenum, collecting ducts and choroid plexus. J Nephrol 23(Suppl 16):S35\u2013S42 (review)","journal-title":"J Nephrol"},{"issue":"6","key":"460_CR21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s40620-016-0329-y","volume":"29","author":"G Gambaro","year":"2016","unstructured":"Gambaro G, Croppi E, Coe F, Lingeman J, Moe O, Worcester E, Buchholz N, Bushinsky D, Curhan GC, Ferraro PM, Fuster D, Goldfarb DS, Heilberg IP, Hess B, Lieske J, Marangella M, Milliner D, Preminger GM, Reis Santos JM, Sakhaee K, Sarica K, Siener R, Strazzullo P, Williams JC (2016) Consensus Conference Group. Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement. J Nephrol 29(6):715\u2013734 (Epub 2016 Jul 25)","journal-title":"J Nephrol"},{"issue":"6","key":"460_CR22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s40620-016-0347-9","volume":"29","author":"P Fabbrini","year":"2016","unstructured":"Fabbrini P, Finkel K, Gallieni M, Capasso G, Cavo M, Santoro A, Pasquali S (2016) Light chains removal by extracorporeal techniques in acute kidney injury due to multiple myeloma: a position statement of the Onconephrology Work Group of the Italian Society of Nephrology. J Nephrol 29(6):735\u2013746 (Epub 2016 Oct 18)","journal-title":"J Nephrol"},{"issue":"11","key":"460_CR23","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1681\/ASN.2015080915","volume":"27","author":"F Trepiccione","year":"2016","unstructured":"Trepiccione F, Gerber SD, Grahammer F, L\u00f3pez-Cayuqueo KI, Baudrie V, P\u0103unescu TG, Capen DE, Picard N, Alexander RT, Huber TB, Chambrey R, Brown D, Houillier P, Eladari D, Simons M (2016) Renal Atp6ap2\/(Pro)renin receptor is required for normal vacuolar H+-ATPase function but not for the renin-angiotensin system. J Am Soc Nephrol 27(11):3320\u20133330","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"460_CR24","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1681\/ASN.2016020169","volume":"28","author":"R Mumtaz","year":"2016","unstructured":"Mumtaz R, Trepiccione F, Hennings JC, Huebner AK, Serbin B, Picard N, Ullah AK, P\u0103unescu TG, Capen DE, Lashhab RM, Mouro-Chanteloup I, Alper SL, Wagner CA, Cordat E, Brown D, Eladari D, H\u00fcbner CA (2016) Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an Ae1 R607H Knockin Model. J Am Soc Nephrol 28(5):1507\u20131520. \n                        http:\/\/dx.doi.org\/10.1681\/ASN.2016020169","journal-title":"J Am Soc Nephrol."},{"issue":"10","key":"460_CR25","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1172\/JCI63492","volume":"123","author":"V Gueutin","year":"2013","unstructured":"Gueutin V, Vallet M, Jayat M, Peti-Peterdi J, Corni\u00e8re N, Leviel F, Sohet F, Wagner CA, Eladari D (2013) Chambrey R.Renal \u03b2-intercalated cells maintain body fluid and electrolyte balance. J Clin Invest 123(10):4219\u20134231","journal-title":"J Clin Invest"},{"issue":"1","key":"460_CR26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00415-014-7551-0","volume":"262","author":"F Sacc\u00e0","year":"2015","unstructured":"Sacc\u00e0 F, Puorro G, Brunetti A, Capasso G, Cervo A, Cocozza S, de Leva M, Marsili A, Pane C, Quarantelli M, Russo CV, Trepiccione F, De Michele G, Filla A, Morra VB (2015) A randomized controlled pilot trial of lithium in spinocerebellar ataxia type 2. J Neurol 262(1):149\u2013153","journal-title":"J Neurol"},{"issue":"4","key":"460_CR27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ki.1976.40","volume":"9","author":"JM Roscoe","year":"1976","unstructured":"Roscoe JM, Goldstein MB, Halperin ML, Wilson DR, Stinebaugh BJ (1976) Lithium-induced impairment of urine acidification. Kidney Int 9(4):344\u2013350","journal-title":"Kidney Int"},{"issue":"Pt 1","key":"460_CR28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1113\/jphysiol.2003.046474","volume":"555","author":"E Odgaard","year":"2004","unstructured":"Odgaard E, Jakobsen JK, Frische S, Praetorius J, Nielsen S, Aalkjaer C, Leipziger J Basolateral Na+-dependent HCO3- transporter NBCn1-mediated HCO3- influx in rat medullary thick ascending limb. J Physiol. 2004;555(Pt 1):205\u2013218 (Epub 2003 Dec 12)","journal-title":"J Physiol"},{"key":"460_CR29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-004-1303-4","volume":"448","author":"JK Jakobsen","year":"2004","unstructured":"Jakobsen JK, Odgaard E, Wang W, Elkjaer ML, Nielsen S, Aalkjaer C, Leipziger J (2004) Functional up-regulation of basolateral Na+-dependent HCO3- transporter NBCn1 in medullary thick ascending limb of K+-depleted rats. Pflugers Arch 448:571\u2013578","journal-title":"Pflugers Arch"},{"key":"460_CR30","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1113\/expphysiol.2010.053967","volume":"95","author":"S Lee","year":"2010","unstructured":"Lee S, Lee HJ, Yang HS, Thornell IM, Bevensee MO, Choi I (2010) Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport. Exp Physiol 95:926\u2013937","journal-title":"Exp Physiol"},{"issue":"Suppl 9","key":"460_CR31","first-page":"S27","volume":"19","author":"Z Karim","year":"2006","unstructured":"Karim Z, Szutkowska M, Vernimmen C, Bichara M (2006) Recent concepts concerning the renal handling of NH3\/NH4+. J Nephrol 19(Suppl 9):S27\u2013S32","journal-title":"J Nephrol"},{"issue":"5","key":"460_CR32","doi-asserted-by":"crossref","first-page":"F901","DOI":"10.1152\/ajprenal.00286.2016","volume":"311","author":"F Trepiccione","year":"2016","unstructured":"Trepiccione F, Soukaseum C, Iervolino A, Petrillo F, Zacchia M, Schutz G, Eladari D, Capasso G, Hadchouel J (2016) A fate-mapping approach reveals the composite origin of the connecting tubule and alerts on \u201csingle-cell\"-specific KO model of the distal nephron. Am J Physiol Renal Physiol 311(5):F901\u2013F906","journal-title":"Am J Physiol Renal Physiol"},{"key":"460_CR33","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1681\/ASN.2007070781","volume":"19","author":"JP DuongHuyen van","year":"2008","unstructured":"Duong van Huyen JP, Cheval L, Bloch-Faure M, Belair MF, Heudes D, Bruneval P, Doucet A (2008) GDF15 triggers homeostatic proliferation of acid-secreting collecting duct cells. J Am Soc Nephrol 19:1965\u20131974","journal-title":"J Am Soc Nephrol"},{"key":"460_CR34","first-page":"317","volume":"84","author":"NG Ordonez","year":"1976","unstructured":"Ordonez NG, Spargo BH (1976) The morphologic relationship of light and dark cells of the collecting tubule in potassium-depleted rats. Am J Pathol 84:317\u2013326","journal-title":"Am J Pathol"},{"key":"460_CR35","doi-asserted-by":"crossref","first-page":"F437","DOI":"10.1152\/ajprenal.2001.280.3.F437","volume":"280","author":"C Bagnis","year":"2001","unstructured":"Bagnis C, Marshansky V, Breton S, Brown D (2001) Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition. Am J Physiol Renal Physiol 280:F437\u2013F448","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40620-017-0460-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-017-0460-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-017-0460-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:57:01Z","timestamp":1777564621000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/31\/3\/385\/8371271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["460"],"URL":"https:\/\/doi.org\/10.1007\/s40620-017-0460-4","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]}}}