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Nevertheless, according to the most recent evidences from literature this organ-based conception of RRIs has been proven to be partial and unable to explain the RRIs variations in clinical settings of sepsis or combined organ failure of primitively extrarenal origin or, more generally, the deep connection between RRIs and hemodynamic factors such as compliance and pulsatility of the large vessels. The aim of this review is\u00a0to explain the physiopathological basis of RRIs determination and the most common interpretative errors in their analysis. Moreover, through a comprehensive vision of these\u00a0Doppler indices, the traditional and emerging clinical application fields for RRIs are\u00a0discussed.<\/jats:p>","DOI":"10.1007\/s40620-018-00567-x","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T12:42:21Z","timestamp":1544532141000},"page":"527-538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Renal intraparenchymal resistive index: the ultrasonographic answer to many clinical questions"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-9185","authenticated-orcid":false,"given":"Pierpaolo","family":"Di Nicol\u00f2","sequence":"first","affiliation":[{"name":"Nephrology and Dialysis Unit, \u201cS. Maria della Scaletta\u201d Hospital, Via Montericco n. 4, 40026, Imola, BO, Italy 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Granata","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, \u201cS. 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