{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:06:53Z","timestamp":1769040413153,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study assessed the contribution of intracorporeal (IC) and extracorporeal clearance (EC) of furosemide in patients with septic acute kidney injury (AKI), and the relationship between plasma concentrations and urine volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cohort observational study of 15 patients with septic AKI undergoing continuous veno-venous hemodiafiltration (CVVHDF) divided according to urine volume (&amp;lt;\u2009500\u00a0ml\/12\u00a0h, Oliguria group, n\u2009=\u20095; &amp;gt; 500\u00a0ml\/12\u00a0h, Diuresis group, n\u2009=\u200910) during continuous infusion of furosemide (120\u00a0mg\/12\u00a0h) at steady-state condition. Plasma and effluent furosemide concentrations were determined by high-performance liquid chromatography (HPLC)-mass spectrometry every 12\u00a0h for 48\u00a0h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Furosemide plasma concentrations and total body clearance (TBC) were 6.14\u00a0mg\/l and 22.1\u00a0ml\/min for the Oliguria group, and 2.63\u00a0mg\/l and 54.4\u00a0ml\/min for the Diuresis group, respectively (p\u2009&amp;lt;\u20090.05). When urine volume was &amp;lt;\u2009500\u00a0ml\/24\u00a0h, the furosemide plasma concentrations peaked at the potentially toxic value of 13.0\u00a0mg\/l. Furosemide EC was not relevant for the Diuresis group, but it represented 18% of TBC for the Oliguria group. Furosemide plasma concentrations correlated positively with dose infusion for both groups (r = 0.728 and 0.685, p\u2009&amp;lt;\u20090.05), and negatively with urine volume only for the Diuresis (r = \u2212 0.578, p\u2009&amp;lt;\u20090.01) but not for the Oliguria group (r = \u2212 0.089, p = 0.715).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For patients with urine volume\u2009&amp;gt;\u2009500\u00a0ml\/12\u00a0h continuous infusion of furosemide up to 480\u00a0mg\/24\u00a0h leads to increasing urine volume, which can predict furosemide plasma levels within its safety range. When the urine volume is lower, the furosemide plasma levels are increased beyond any further diuretic efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-018-0537-8","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T06:00:10Z","timestamp":1537164010000},"page":"889-897","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Urine volume as a predicting factor for furosemide clearance during continuous infusion in AKI septic shock patients on hemodiafiltration"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-2141","authenticated-orcid":false,"given":"Filippo","family":"Mariano","sequence":"first","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit, Department of Medical Sciences, City of Health and Science, CTO Hospital, University of Turin, Via G. Zuretti 29, 10126 Turin, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Leporati","sequence":"additional","affiliation":[{"name":"Regional Antidoping and Toxicology Center \u201cAlessandro Bertinaria\u201d, Orbassano Turin, Italy 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Carignano","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care 3, Department of Anesthesia and Intensive Care, City of Health and Science, CTO Hospital, Turin, Italy 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Stella","sequence":"additional","affiliation":[{"name":"Plastic Surgery and Major Burns, Department of General and Specialized Surgery, City of Health and Science, CTO Hospital, Turin, Italy 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Vincenti","sequence":"additional","affiliation":[{"name":"Regional Antidoping and Toxicology Center \u201cAlessandro Bertinaria\u201d, Orbassano Turin, Italy 2"},{"name":"Department of Chemistry, University of Turin, Turin, Italy 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Biancone","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit, Department of Medical Sciences, City of Health and Science, CTO Hospital, University of Turin, Via G. 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