{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:28:15Z","timestamp":1775791695746,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["15K08719"],"award-info":[{"award-number":["15K08719"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"he Kidney Foundation Japan"},{"name":"Toranomon Hospital"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["18K08227"],"award-info":[{"award-number":["18K08227"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Grants-in-Aid for Scientific Research","award":["15K08719"],"award-info":[{"award-number":["15K08719"]}]},{"name":"he Kidney Foundation Japan"},{"name":"Toranomon Hospital"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08227"],"award-info":[{"award-number":["18K08227"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A recent study demonstrated that tolvaptan slowed estimated glomerular filtration rate (eGFR) decline in later-stage autosomal dominant polycystic kidney disease (ADPKD) patients. However, Japanese patients were not included in that trial, therefore tolvaptan\u2019s efficacy in Japanese patients with advanced chronic kidney disease (CKD) has remained unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, 54 patients with ADPKD who had eGFR\u2009\u2265\u200915\u00a0ml\/min\/1.73\u00a0m2 and total kidney volume (TKV)\u2009\u2265\u2009750\u00a0ml were treated with tolvaptan. The primary endpoint was the change in height-adjusted total kidney volume (htTKV) and eGFR after 1-year treatment with tolvaptan. Then, we compared the primary endpoint between later CKD stage (baseline eGFR\u2009&amp;lt;\u200945\u00a0ml\/min\/1.73\u00a0m2) and earlier CKD stage (baseline eGFR\u2009\u2265\u200945\u00a0ml\/min\/1.73\u00a0m2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The rate of kidney growth during the 1-year treatment did not differ significantly between earlier and later CKD stages. The median and interquartile range of relative change in htTKV in later CKD stage was 8.2%\/year [4.4, 26.6], as compared with 5.7%\/year [1.6, 16.4] in earlier CKD stage (p\u2009=\u20090.17). Nor did the rate of eGFR decline between earlier and later CKD stages. The relative annual change in eGFR in later CKD stage was \u2212\u20099.7%\/year [\u2212\u200915.9, \u2212\u20092.1], as compared with \u2212\u20096.8%\/year\u00a0[\u2212\u200911.1, 0.1] in earlier CKD stage (p\u2009=\u20090.18).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis indicates that the efficacy of tolvaptan for Japanese patients with later stage ADPKD was not significantly different from that of Japanese patients with earlier stage ADPKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-018-0545-8","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T11:39:08Z","timestamp":1540381148000},"page":"961-966","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tolvaptan in Japanese patients with later-stage autosomal dominant 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