{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:47:37Z","timestamp":1790390857855,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s40620-019-00599-x","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T03:04:48Z","timestamp":1552964688000},"page":"645-659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cholecalciferol supplementation increases FGF23 in peritoneal dialysis patients with hypovitaminosis D: a randomized clinical trial"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-2941","authenticated-orcid":false,"given":"Juan C.","family":"Ramirez-Sandoval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Arvizu-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristino","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vazquez-Cantu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"Rojas-Concha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Tamez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fagundo","family":"Reynerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-6710","authenticated-orcid":false,"given":"F. Enrique","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-8285","authenticated-orcid":false,"given":"Ricardo","family":"Correa-Rotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"599_CR1","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.2215\/CJN.05781207","volume":"3","author":"R Mehrotra","year":"2008","unstructured":"Mehrotra R, Kermah D, Budoff M et al (2008) Hypovitaminosis D in chronic kidney disease. Clin J Am Soc Nephrol 3:1144\u20131151","journal-title":"Clin J Am Soc Nephrol"},{"key":"599_CR2","doi-asserted-by":"publisher","first-page":"F8","DOI":"10.1152\/ajprenal.00336.2004","volume":"289","author":"AS Dusso","year":"2005","unstructured":"Dusso AS, Brown AJ, Slatopolsky E (2005) Vitamin D. Am J Physiol Ren Physiol 289:F8\u2013F28","journal-title":"Am J Physiol Ren Physiol"},{"key":"599_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","volume":"7","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group","year":"2017","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group (2017) KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease\u2013mineral and bone disorder (CKD\u2013MBD). Kidney Int Suppl 7:1\u201359","journal-title":"Kidney Int Suppl"},{"key":"599_CR4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1053\/j.ajkd.2014.05.018","volume":"64","author":"H Kramer","year":"2014","unstructured":"Kramer H, Berns JS, Choi MJ et al (2014) 25-Hydroxyvitamin D testing and supplementation in CKD: an NKF-KDOQI controversies report. Am J Kidney Dis 64:499\u2013509","journal-title":"Am J Kidney Dis"},{"key":"599_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s40620-016-0305-6","volume":"29","author":"LF Morrone","year":"2016","unstructured":"Morrone LF, Bolasco P, Camerini C et al (2016) Vitamin D in patients with chronic kidney disease: a position statement of the Working Group \u201cTrace Elements and Mineral Metabolism\u201d of the Italian Society of Nephrology. J Nephrol 29:305\u2013328","journal-title":"J Nephrol"},{"key":"599_CR6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1053\/j.jrn.2010.03.005","volume":"20","author":"C Gracia-Iguacel","year":"2010","unstructured":"Gracia-Iguacel C, Gallar P, Qureshi AR et al (2010) Vitamin D deficiency in dialysis patients: effect of dialysis modality and implications on outcome. J Ren Nutr 20:359\u2013367","journal-title":"J Ren Nutr"},{"key":"599_CR7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.5414\/CNP66247","volume":"66","author":"H Taskapan","year":"2006","unstructured":"Taskapan H, Ersoy FF, Passadakis PS et al (2006) Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis. Clin Nephrol 66:247\u2013255","journal-title":"Clin Nephrol"},{"key":"599_CR8","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s11255-009-9561-x","volume":"41","author":"G Sahin","year":"2009","unstructured":"Sahin G, Kirli I, Sirmagul B et al (2009) Loss via peritoneal fluid as a factor for low 25(OH)D3 level in peritoneal dialysis patients. Int Urol Nephrol 41:989\u2013996","journal-title":"Int Urol Nephrol"},{"key":"599_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s40620-014-0120-x","volume":"27","author":"R Russo","year":"2014","unstructured":"Russo R, Ruospo M, Cozzolino M et al (2014) Effects of vitamin D on parathyroid hormone and clinical outcomes in peritoneal dialysis: a narrative review. J Nephrol 27:483\u2013494","journal-title":"J Nephrol"},{"key":"599_CR10","first-page":"S5","volume":"19","author":"S Williams","year":"2009","unstructured":"Williams S, Malatesta K, Norris K (2009) Vitamin D and chronic kidney disease. Ethn Dis 19:S5\u2013S8","journal-title":"Ethn Dis"},{"key":"599_CR11","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1001\/archinte.167.11.1159","volume":"167","author":"D Martins","year":"2007","unstructured":"Martins D, Wolf M, Pan D et al (2007) Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States. Arch Intern Med 167:1159\u20131165","journal-title":"Arch Intern Med"},{"key":"599_CR12","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1210\/en.2014-1744","volume":"156","author":"A Mary","year":"2015","unstructured":"Mary A, H\u00e9naut L, Boudot C et al (2015) Calcitriol prevents in vitro vascular smooth muscle cell mineralization by regulating calcium-sensing receptor expression. Endocrinology 156:1965\u20131974","journal-title":"Endocrinology"},{"key":"599_CR13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s40620-014-0167-8","volume":"28","author":"QY Zhang","year":"2015","unstructured":"Zhang QY, Jiang CM, Sun C et al (2015) Hypovitaminosis D is associated with endothelial dysfunction in patients with non-dialysis chronic kidney disease. J Nephrol 28:471\u2013476","journal-title":"J Nephrol"},{"key":"599_CR14","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s40620-015-0201-5","volume":"28","author":"AS Bargnoux","year":"2015","unstructured":"Bargnoux AS, Vetromile F, Kuster N et al (2015) Markers of bone remodeling are associated with arterial stiffness in renal transplanted subjects. J Nephrol 28:765\u2013772","journal-title":"J Nephrol"},{"key":"599_CR15","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s40620-014-0040-9","volume":"27","author":"E Charitaki","year":"2014","unstructured":"Charitaki E, Davenport A (2014) Aortic pulse wave velocity in haemodialysis patients is associated with the prescription of active vitamin D analogues. J Nephrol 27:431\u2013437","journal-title":"J Nephrol"},{"key":"599_CR16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3109\/0886022X.2013.832308","volume":"36","author":"S Lai","year":"2014","unstructured":"Lai S, Coppola B, Dimko M et al (2014) Vitamin D deficiency, insulin resistance, and ventricular hypertrophy in the early stages of chronic kidney disease. Ren Fail 36:58\u201364","journal-title":"Ren Fail"},{"key":"599_CR17","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s40620-015-0236-7","volume":"29","author":"M Fusaro","year":"2016","unstructured":"Fusaro M, Gallieni M, Rebora P et al (2016) Atrial fibrillation and low vitamin D levels are associated with severe vascular calcifications in hemodialysis patients. J Nephrol 29:419\u2013426","journal-title":"J Nephrol"},{"key":"599_CR18","doi-asserted-by":"crossref","first-page":"76857","DOI":"10.18632\/oncotarget.20167","volume":"8","author":"C Shen","year":"2017","unstructured":"Shen C, Yuan Y, Li F et al (2017) Mechanism of genistein regulating the differentiation of vascular smooth muscle cells into osteoblasts via the OPG\/RANKL pathway. Oncotarget 8:76857\u201376864","journal-title":"Oncotarget"},{"key":"599_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.numecd.2013.08.006","volume":"24","author":"JW Huang","year":"2014","unstructured":"Huang JW, Lien YC, Yang CY et al (2014) Osteoprotegerin, inflammation and dyslipidemia are associated with abdominal aortic calcification in non-diabetic patients on peritoneal dialysis. Nutr Metab Cardiovasc Dis 24:236\u2013242","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"599_CR20","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3747\/pdi.2014.00250","volume":"36","author":"JC Ramirez-Sandoval","year":"2016","unstructured":"Ramirez-Sandoval JC, Casanova I, Villar A et al (2016) Biomarkers associated with vascular calcification in peritoneal dialysis. Perit Dial Int 36:262\u2013268","journal-title":"Perit Dial Int"},{"key":"599_CR21","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.arcmed.2013.10.015","volume":"44","author":"M \u00c1vila-D\u00edaz","year":"2013","unstructured":"\u00c1vila-D\u00edaz M, Mora-Villalpando C, Prado-Uribe M del C, et al (2013) De novo development of heart valve calcification in incident peritoneal dialysis patients. Arch Med Res 44:638\u2013644","journal-title":"Arch Med Res"},{"key":"599_CR22","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.atherosclerosis.2011.09.025","volume":"219","author":"HM Koo","year":"2011","unstructured":"Koo HM, Do HM, Kim EJ et al (2011) Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients. Atherosclerosis 219:925\u2013930","journal-title":"Atherosclerosis"},{"key":"599_CR23","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.vph.2016.07.003","volume":"86","author":"C Vassalle","year":"2016","unstructured":"Vassalle C, Mazzone A (2016) Bone loss and vascular calcification: a bi-directional interplay? Vasc Pharmacol 86:77\u201386","journal-title":"Vasc Pharmacol"},{"key":"599_CR24","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1359\/JBMR.0301264","volume":"19","author":"T Shimada","year":"2004","unstructured":"Shimada T, Hasegawa H, Yamazaki Y et al (2004) FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Min Res 19:429\u2013435","journal-title":"J Bone Min Res"},{"key":"599_CR25","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/ki.2010.352","volume":"79","author":"K Wesseling-Perry","year":"2011","unstructured":"Wesseling-Perry K, Pereira RC, Sahney S et al (2011) Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism. Kidney Int 79:112\u2013119","journal-title":"Kidney Int"},{"key":"599_CR26","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.1093\/ndt\/gfs138","volume":"27","author":"P Marckmann","year":"2012","unstructured":"Marckmann P, Agerskov H, Thineshkumar S et al (2012) Randomized controlled trial of cholecalciferol supplementation in chronic kidney disease patients with hypovitaminosis D. Nephrol Dial Transplant 27:3523\u20133531","journal-title":"Nephrol Dial Transplant"},{"key":"599_CR27","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/ki.2013.3","volume":"83","author":"JJ Scialla","year":"2013","unstructured":"Scialla JJ, Lau WL, Reilly MP et al (2013) Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney Int 83:1159\u20131168","journal-title":"Kidney Int"},{"key":"599_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu9040328","volume":"9","author":"G Jean","year":"2017","unstructured":"Jean G, Souberbielle JC, Chazot C (2017) Vitamin D in chronic kidney disease and dialysis patients. Nutrients 9:1\u201315","journal-title":"Nutrients"},{"key":"599_CR29","doi-asserted-by":"publisher","first-page":"611","DOI":"10.2215\/CJN.06910714","volume":"10","author":"I Bhan","year":"2015","unstructured":"Bhan I, Dobens D, Tamez H et al (2015) Nutritional vitamin D supplementation in dialysis: a randomized trial. Clin J Am Soc Nephrol 10:611\u2013619","journal-title":"Clin J Am Soc Nephrol"},{"key":"599_CR30","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.1210\/jc.2004-0360","volume":"89","author":"LAG Armas","year":"2004","unstructured":"Armas LAG, Hollis BW, Heaney RP (2004) Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab 89:5387\u20135391","journal-title":"J Clin Endocrinol Metab"},{"key":"599_CR31","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1681\/ASN.2013030314","volume":"24","author":"M Lambie","year":"2013","unstructured":"Lambie M, Chess J, Donovan KL et al (2013) Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival. J Am Soc Nephrol 24:2071\u20132080","journal-title":"J Am Soc Nephrol"},{"key":"599_CR32","doi-asserted-by":"publisher","first-page":"127","DOI":"10.7326\/0003-4819-128-2-199801150-00009","volume":"128","author":"DA Papanicolaou","year":"1998","unstructured":"Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP (1998) The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med 128:127\u2013137","journal-title":"Ann Intern Med"},{"key":"599_CR33","first-page":"1","volume":"12","author":"JTG Carvalho","year":"2017","unstructured":"Carvalho JTG, Schneider M, Cuppari L et al (2017) Cholecalciferol decreases inflammation and improves Vitamin D regulatory enzymes in lymphocytes in the uremic environment: a randomized controlled pilot trial. PLoS One 12:1\u201315","journal-title":"PLoS One"},{"key":"599_CR34","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1093\/ndt\/gfx059","volume":"33","author":"P-A Westerberg","year":"2017","unstructured":"Westerberg P-A, Sterner G, Ljunggren \u00d6 et al (2017) High doses of cholecalciferol alleviate the progression of hyperparathyroidism in patients with CKD Stages 3\u20134: results of a 12-week double-blind, randomized, controlled study. Nephrol Dial Transpl 33:466\u2013471","journal-title":"Nephrol Dial Transpl"},{"key":"599_CR35","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.clnu.2016.05.012","volume":"36","author":"DR Mager","year":"2017","unstructured":"Mager DR, Jackson ST, Hoffmann MR et al (2017) Vitamin D3 supplementation, bone health and quality of life in adults with diabetes and chronic kidney disease: results of an open label randomized clinical trial. Clin Nutr 36:686\u2013696","journal-title":"Clin Nutr"},{"key":"599_CR36","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jsbmb.2014.11.022","volume":"148","author":"M Petkovich","year":"2015","unstructured":"Petkovich M, Melnick J, White J et al (2015) Modified-release oral calcifediol corrects vitamin D insufficiency with minimal CYP24A1 upregulation. J Steroid Biochem Mol Biol 148:283\u2013289","journal-title":"J Steroid Biochem Mol Biol"},{"key":"599_CR37","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1053\/j.ajkd.2014.04.020","volume":"64","author":"A Massart","year":"2014","unstructured":"Massart A, Debelle FD, Racap\u00e9 J et al (2014) Biochemical parameters after Cholecalciferol repletion in hemodialysis: results from the vitadial randomized trial. Am J Kidney Dis 64:696\u2013705","journal-title":"Am J Kidney Dis"},{"key":"599_CR38","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.2215\/CJN.03130314","volume":"9","author":"JR Stubbs","year":"2014","unstructured":"Stubbs JR, Zhang S, Friedman PA, Nolin TD (2014) Decreased conversion of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 following cholecalciferol therapy in patients with CKD. Clin J Am Soc Nephrol 9:1965\u20131973","journal-title":"Clin J Am Soc Nephrol"},{"key":"599_CR39","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000354717","volume":"123","author":"E Seibert","year":"2013","unstructured":"Seibert E, Heine GH, Ulrich C et al (2013) Influence of cholecalciferol supplementation in hemodialysis patients on monocyte subsets: a randomized, double-blind, placebo-controlled clinical trial. Nephron Clin Pract 123:209\u2013219","journal-title":"Nephron Clin Pract"},{"key":"599_CR40","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3109\/00365513.2012.744464","volume":"73","author":"E Gravesen","year":"2013","unstructured":"Gravesen E, Hofman-Bang J, Lewin E, Olgaard K (2013) Ergocalciferol treatment and aspects of mineral homeostasis in patients with chronic kidney disease stage 4\u20135. Scand J Clin Lab Invest 73:107\u2013116","journal-title":"Scand J Clin Lab Invest"},{"key":"599_CR41","first-page":"277","volume":"123","author":"T Hryszko","year":"2013","unstructured":"Hryszko T, Rydzewska-Rosolowska A, Gozdzikiewicz J et al (2013) Cholecalciferol supplementation reduces soluble Klotho concentration in hemodialysis patients. Pol Arch Med Wewn 123:277\u2013281","journal-title":"Pol Arch Med Wewn"},{"key":"599_CR42","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3945\/ajcn.112.040642","volume":"96","author":"JA Alvarez","year":"2012","unstructured":"Alvarez JA, Law J, Coakley KE et al (2012) High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 96:672\u2013679","journal-title":"Am J Clin Nutr"},{"key":"599_CR43","doi-asserted-by":"publisher","first-page":"64","DOI":"10.5414\/CNP64064","volume":"64","author":"JJ Kazama","year":"2005","unstructured":"Kazama JJ, Omori K, Takahashi N et al (2005) Maxacalcitol therapy decreases circulating osteoprotegerin levels in dialysis patients with secondary hyperparathyroidism. Clin Nephrol 64:64\u201368","journal-title":"Clin Nephrol"},{"key":"599_CR44","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.advms.2016.08.001","volume":"62","author":"B Znorko","year":"2017","unstructured":"Znorko B, Oksztulska-Kolanek E, Michalowska M et al (2017) Does the OPG\/RANKL system contribute to the bone-vascular axis in chronic kidney disease? A systematic review. Adv Med Sci 62:52\u201364","journal-title":"Adv Med Sci"},{"key":"599_CR45","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1007\/s11255-017-1643-6","volume":"49","author":"H Zakaria","year":"2017","unstructured":"Zakaria H, Mostafa TM, El-Azab G et al (2017) The impact of fish oil and wheat germ oil combination on mineral-bone and inflammatory markers in maintenance hemodialysis patients: a randomized, double-blind, placebo-controlled clinical trial. Int Urol Nephrol 49:1851\u20131858","journal-title":"Int Urol Nephrol"},{"key":"599_CR46","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1111\/j.1542-4758.2007.00224.x","volume":"11","author":"H Othmane Tel","year":"2007","unstructured":"Othmane Tel H, Bakonyi G, Egresits J et al (2007) Effect of sevelamer on aortic pulse wave velocity in patients on hemodialysis: a prospective observational study. Hemodial Int 11:S13\u2013S21","journal-title":"Hemodial Int"},{"key":"599_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2369-15-130","volume":"15","author":"D Hansen","year":"2014","unstructured":"Hansen D, Rasmussen K, Rasmussen LM et al (2014) The influence of vitamin D analogs on calcification modulators, N-terminal pro-B-type natriuretic peptide and inflammatory markers in hemodialysis patients: a randomized crossover study. BMC Nephrol 15:1\u201311","journal-title":"BMC Nephrol"},{"key":"599_CR48","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1073\/pnas.1221255110","volume":"110","author":"ZC Ryan","year":"2013","unstructured":"Ryan ZC, Ketha H, McNulty MS et al (2013) Sclerostin alters serum vitamin D metabolite and fi broblast growth factor 23 concentrations and the urinary excretion of calcium. Proc Natl Acad Sci USA 110:6199\u20136204","journal-title":"Proc Natl Acad Sci USA"},{"key":"599_CR49","doi-asserted-by":"crossref","unstructured":"Tartaglione L, Pasquali M, Rotondi S et al (2017) Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation. 12: e0178637","DOI":"10.1371\/journal.pone.0178637"},{"key":"599_CR50","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-0557-4","author":"L Xu","year":"2018","unstructured":"Xu L, Hu X, Chen W (2018) Fibroblast growth factor-23 correlates with advanced disease conditions and predicts high risk of major adverse cardiac and cerebral events in end-stage renal disease patients undergoing continuous ambulatory peritoneal dialysis. J Nephrol. https:\/\/doi.org\/10.1007\/s40620-018-0557-4 (in press)","journal-title":"J Nephrol"},{"key":"599_CR51","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1681\/ASN.2017070772","volume":"29","author":"T Isakova","year":"2017","unstructured":"Isakova T, Cai X, Lee J et al (2017) Longitudinal FGF23 trajectories and mortality in patients with CKD. J Am Soc Nephrol 29:579\u2013590","journal-title":"J Am Soc Nephrol"},{"key":"599_CR52","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1074\/jbc.M408903200","volume":"280","author":"H Saito","year":"2005","unstructured":"Saito H, Maeda A, Ohtomo SI et al (2005) Circulating FGF-23 is regulated by 1\u03b1,25-dihydroxyvitamin D3 and phosphorus in vivo. J Biol Chem 280:2543\u20132549","journal-title":"J Biol Chem"},{"key":"599_CR53","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1017\/S000711451600427X","volume":"116","author":"JB Wetmore","year":"2016","unstructured":"Wetmore JB, Kimber C, Mahnken JD, Stubbs JR (2016) Cholecalciferol v. ergocalciferol for 25-hydroxyvitamin D (25(OH)D) repletion in chronic kidney disease: a randomised clinical trial. Br J Nutr 116:2074\u20132081","journal-title":"Br J Nutr"},{"key":"599_CR54","doi-asserted-by":"publisher","first-page":"383","DOI":"10.2215\/CJN.04730510","volume":"6","author":"MG Vervloet","year":"2011","unstructured":"Vervloet MG, van Ittersum FJ, B\u00fcttler RM et al (2011) Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. Clin J Am Soc Nephrol 6:383\u2013389","journal-title":"Clin J Am Soc Nephrol"},{"key":"599_CR55","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1681\/ASN.2011101006","volume":"23","author":"ME Rodriguez-Ortiz","year":"2012","unstructured":"Rodriguez-Ortiz ME, Lopez I, Mu\u00f1oz-Casta\u00f1eda JR et al (2012) Calcium deficiency reduces circulating levels of FGF23. J Am Soc Nephrol 23:1190\u20131197","journal-title":"J Am Soc Nephrol"},{"key":"599_CR56","doi-asserted-by":"publisher","first-page":"c74","DOI":"10.1159\/000319650","volume":"117","author":"ALE Cancela","year":"2011","unstructured":"Cancela ALE, Oliveira RB, Graciolli FG et al (2011) Fibroblast growth factor 23 in hemodialysis patients: effects of phosphate binder, calcitriol and calcium concentration in the dialysate. Nephron Clin Pr 117:c74\u2013c82","journal-title":"Nephron Clin Pr"},{"key":"599_CR57","doi-asserted-by":"publisher","first-page":"999","DOI":"10.2147\/TCRM.S142564","volume":"13","author":"SH Hong","year":"2017","unstructured":"Hong SH, Kim YS, Kim DK, Kim I (2017) Effect of additive calcium administration on FGF23 levels in patients with mild chronic kidney disease treated with calcitriol: a randomized, open-labeled clinical trial. Ther Clin Risk Manag 13:999\u20131007","journal-title":"Ther Clin Risk Manag"},{"key":"599_CR58","doi-asserted-by":"publisher","first-page":"286","DOI":"10.2215\/CJN.05420709","volume":"5","author":"RB Oliveira","year":"2010","unstructured":"Oliveira RB, Cancela ALE, Graciolli FG et al (2010) Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy? Clin J Am Soc Nephrol 5:286\u2013291","journal-title":"Clin J Am Soc Nephrol"},{"key":"599_CR59","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/ejcn.2017.59","volume":"71","author":"RJ Lu","year":"2017","unstructured":"Lu RJ, Zhu SM, Tang FL et al (2017) Effects of vitamin D or its analogues on the mortality of patients with chronic kidney disease: an updated systematic review and meta-analysis. Eur J Clin Nutr 71:683\u2013693","journal-title":"Eur J Clin Nutr"},{"key":"599_CR60","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1093\/ndt\/gfr668","volume":"27","author":"D Hansen","year":"2012","unstructured":"Hansen D, Rasmussen K, Pedersen SM et al (2012) Changes in fibroblast growth factor 23 during treatment of secondary hyperparathyroidism with alfacalcidol or paricalcitol. Nephrol Dial Transpl 27:2263\u20132269","journal-title":"Nephrol Dial Transpl"},{"key":"599_CR61","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1159\/000450766","volume":"44","author":"SM Sprague","year":"2016","unstructured":"Sprague SM, Crawford PW, Melnick JZ et al (2016) Use of extended-release calcifediol to treat secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease. Am J Nephrol 44:316\u2013325","journal-title":"Am J Nephrol"},{"key":"599_CR62","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1093\/ndt\/gft236","volume":"28","author":"AC Heijboer","year":"2013","unstructured":"Heijboer AC, Blankenstein MA, Hoenderop J et al (2013) Laboratory aspects of circulating \u03b1-Klotho. Nephrol Dial Transpl 28:2283\u20132287","journal-title":"Nephrol Dial Transpl"},{"key":"599_CR63","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3109\/14397595.2014.926852","volume":"25","author":"HH Wang","year":"2015","unstructured":"Wang HH, Xiang G, Da (2015) Changes of plasma concentration of osteoprotegerin and its association with endothelial dysfunction before and after hypouricemic therapy in patients with hyperuricemia. Mod Rheumatol 25:123\u2013127","journal-title":"Mod Rheumatol"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-019-00599-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40620-019-00599-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-019-00599-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:56:18Z","timestamp":1777564578000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/32\/4\/645\/8328211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["599"],"URL":"https:\/\/doi.org\/10.1007\/s40620-019-00599-x","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"22 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol has been approved by the research institute\u2019s committee on human research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"Registered at ClinicalTrials.gov, with study number NCT02598635.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Trial registration"}}]}}