{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:21:59Z","timestamp":1789611719541,"version":"build-2803163510"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s40620-019-00612-3","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T02:07:43Z","timestamp":1556158063000},"page":"83-89","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Morphological evaluation of sympathetic renal innervation in patients with autosomal dominant polycystic kidney disease"],"prefix":"10.1093","volume":"33","author":[{"given":"Valentina","family":"Rovella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-1309","authenticated-orcid":false,"given":"Manuel","family":"Scimeca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"D\u2019Ercole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Giacobbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Noce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"D\u2019Urso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Anselmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Bove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Santeusanio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bonanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Casasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvestro","family":"Mauriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Di Daniele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Mauriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Anemona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"612_CR1","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/S0140-6736(15)60907-2","volume":"385","author":"AC Ong","year":"2015","unstructured":"Ong AC, Devuyst O, Knebelmann B, Walz G (2015) Autosomal dominant polycystic kidney disease: the changing face of clinical management. Lancet 385:1993\u20132002","journal-title":"Lancet"},{"key":"612_CR2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ki.2015.59","volume":"88","author":"AB Chapman","year":"2015","unstructured":"Chapman AB, Devuyst O, Eckardt KU et al (2015) Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 88:17\u201327","journal-title":"Kidney Int"},{"key":"612_CR3","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1046\/j.1523-1755.2003.00776.x","volume":"63","author":"RW Schrier","year":"2003","unstructured":"Schrier RW, McFann KK, Johnson AM (2003) Epidemiological study of kidney survival in autosomal dominant polycystic kidney disease. Kidney Int 63:678\u2013685","journal-title":"Kidney Int"},{"key":"612_CR4","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1056\/NEJMoa1402686","volume":"371","author":"VE Torres","year":"2014","unstructured":"Torres VE, Abebe KZ, Chapman AB et al (2014) Angiotensin blockade in late autosomal dominant polycystic kidney disease. N Engl J Med 371:2267\u20132276","journal-title":"N Engl J Med"},{"key":"612_CR5","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1681\/ASN.V12112427","volume":"12","author":"IH Klein","year":"2001","unstructured":"Klein IH, Ligtenberg G, Oey PL, Koomans HA, Blankestijn PJ (2001) Sympathetic activity is increased in polycystic kidney disease and is associated with hypertension. J Am Soc Nephrol 12:2427\u20132433","journal-title":"J Am Soc Nephrol"},{"key":"612_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s40620-018-0514-2","volume":"32","author":"I Kocyigit","year":"2019","unstructured":"Kocyigit I, Eroglu E, Kaynar AS et al (2019) The association of endothelin-1 levels with renal survival in polycystic kidney disease patients. J Nephrol 32:83\u201391","journal-title":"J Nephrol"},{"key":"612_CR7","doi-asserted-by":"publisher","first-page":"e002426","DOI":"10.1161\/JAHA.115.002426","volume":"4","author":"A Mauriello","year":"2015","unstructured":"Mauriello A, Rovella V, Anemona L et al (2015) Increased sympathetic renal innervation in hemodialysis patients is the anatomical substrate of sympathetic hyperactivity in end-stage renal disease. J Am Heart Assoc 4:e002426","journal-title":"J Am Heart Assoc"},{"key":"612_CR8","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1016\/j.ijcard.2012.05.114","volume":"162","author":"SV Shetty","year":"2013","unstructured":"Shetty SV, Roberts TJ, Schlaich MP (2013) Percutaneous transluminal renal denervation: a potential treatment option for polycystic kidney disease-related pain? Int J Cardiol 162:e58\u2013e59","journal-title":"Int J Cardiol"},{"key":"612_CR9","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1053\/j.ajkd.2013.12.011","volume":"63","author":"NF Casteleijn","year":"2014","unstructured":"Casteleijn NF, de Jager RL, Neeleman MP, Blankestijn PJ, Gansevoort RT (2014) Chronic kidney pain in autosomal dominant polycystic kidney disease: a case report of successful treatment by catheter-based renal denervation. Am J Kidney Dis 63:1019\u20131021","journal-title":"Am J Kidney Dis"},{"key":"612_CR10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00392-013-0647-1","volume":"103","author":"A Prejbisz","year":"2014","unstructured":"Prejbisz A, Kadziela J, Lewandowski J et al (2014) Effect of percutaneous renal denervation on blood pressure level and sympathetic activity in a patient with polycystic kidney disease. Clin Res Cardiol 103:251\u2013253","journal-title":"Clin Res Cardiol"},{"key":"612_CR11","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.jcin.2014.04.024","volume":"7","author":"K Sakakura","year":"2014","unstructured":"Sakakura K, Ladich E, Edelman ER et al (2014) Methodological standardization for the pre-clinical evaluation of renal sympathetic denervation. JACC Cardiovasc Interv 7:1184\u20131193","journal-title":"JACC Cardiovasc Interv"},{"key":"612_CR12","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1161\/hc0302.102610","volume":"105","author":"AP Burke","year":"2002","unstructured":"Burke AP, Kolodgie FD, Farb A, Weber D, Virmani R (2002) Morphological predictors of arterial remodeling in coronary atherosclerosis. Circulation 105:297\u2013303","journal-title":"Circulation"},{"key":"612_CR13","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/ndt\/gfx069","volume":"32","author":"A Mauriello","year":"2017","unstructured":"Mauriello A, Rovella V, Borri F et al (2017) Hypertension in kidney transplantation is associated with an early renal nerve sprouting. Nephrol Dial Transplant 32:1053\u20131060","journal-title":"Nephrol Dial Transplant"},{"key":"612_CR14","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1056\/NEJM199212313272704","volume":"327","author":"RL Converse Jr","year":"1992","unstructured":"Converse RL Jr, Jacobsen TN, Toto RD et al (1992) Sympathetic overactivity in patients with chronic renal failure. N Engl J Med 327:1912\u20131918","journal-title":"N Engl J Med"},{"key":"612_CR15","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1161\/HYPERTENSIONAHA.110.167189","volume":"57","author":"MP Schlaich","year":"2011","unstructured":"Schlaich MP (2011) Sympathetic activation in chronic kidney disease: out of the shadow. Hypertension 57:683\u2013685","journal-title":"Hypertension"},{"key":"612_CR16","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1161\/HYPERTENSIONAHA.110.164780","volume":"57","author":"G Grassi","year":"2011","unstructured":"Grassi G, Quarti-Trevano F, Seravalle G et al (2011) Early sympathetic activation in the initial clinical stages of chronic renal failure. Hypertension 57:846\u2013851","journal-title":"Hypertension"},{"key":"612_CR17","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/sdi.12093","volume":"26","author":"D Rubinger","year":"2013","unstructured":"Rubinger D, Backenroth R, Sapoznikov D (2013) Sympathetic nervous system function and dysfunction in chronic hemodialysis patients. Semin Dial 26:333\u2013343","journal-title":"Semin Dial"},{"key":"612_CR18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/MNH.0b013e32834db45d","volume":"21","author":"G Grassi","year":"2012","unstructured":"Grassi G, Bertoli S, Seravalle G (2012) Sympathetic nervous system: role in hypertension and in chronic kidney disease. Curr Opin Nephrol Hypertens 21:46\u201351","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"612_CR19","doi-asserted-by":"publisher","first-page":"R937","DOI":"10.1152\/ajpregu.2000.278.4.R937","volume":"278","author":"UC Kopp","year":"2000","unstructured":"Kopp UC, Farley DM, Cicha MZ, Smith LA (2000) Activation of renal mechanosensitive neurons involves bradykinin, protein kinase C, PGE(2), and substance P. Am J Physiol Regul Integr Comp Physiol 278:R937\u2013R946","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"612_CR20","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1124\/jpet.108.136374","volume":"325","author":"C Xie","year":"2008","unstructured":"Xie C, Sachs JR, Wang DH (2008) Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors. J Pharmacol Exp Ther 325:751\u2013757","journal-title":"J Pharmacol Exp Ther"},{"key":"612_CR21","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1681\/ASN.2008080882","volume":"20","author":"RW Schrier","year":"2009","unstructured":"Schrier RW (2009) Renal volume, renin-angiotensin-aldosterone system, hypertension, and left ventricular hypertrophy in patients with autosomal dominant polycystic kidney disease. J Am Soc Nephrol 20:1888\u20131893","journal-title":"J Am Soc Nephrol"},{"key":"612_CR22","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1053\/j.ajkd.2011.12.018","volume":"59","author":"N Walsh","year":"2012","unstructured":"Walsh N, Sarria JE (2012) Management of chronic pain in a patient with autosomal dominant polycystic kidney disease by sequential celiac plexus blockade, radiofrequency ablation, and spinal cord stimulation. Am J Kidney Dis 59:858\u2013861","journal-title":"Am J Kidney Dis"},{"key":"612_CR23","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1038\/nm935","volume":"9","author":"VH Gattone 2nd","year":"2003","unstructured":"Gattone VH 2nd, Wang X, Harris PC, Torres VE (2003) Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist. Nat Med 9:1323\u20131326","journal-title":"Nat Med"},{"key":"612_CR24","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/imj.13143","volume":"46","author":"GK Rangan","year":"2016","unstructured":"Rangan GK, Tchan MC, Tong A, Wong AT, Nankivell BJ (2016) Recent advances in autosomal-dominant polycystic kidney disease. Intern Med J 46:883\u2013892","journal-title":"Intern Med J"},{"key":"612_CR25","first-page":"158","volume":"102","author":"JJ Grantham","year":"1989","unstructured":"Grantham JJ, Mangoo-Karim R, Uchic ME et al (1989) Net fluid secretion by mammalian renal epithelial cells: stimulation by cAMP in polarized cultures derived from established renal cells and from normal and polycystic kidneys. Trans Assoc Am Physicians 102:158\u2013162","journal-title":"Trans Assoc Am Physicians"},{"key":"612_CR26","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1056\/NEJMoa1205511","volume":"367","author":"VE Torres","year":"2012","unstructured":"Torres VE, Chapman AB, Devuyst O et al (2012) Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med 367:2407\u20132418","journal-title":"N Engl J Med"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-019-00612-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40620-019-00612-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-019-00612-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:56:21Z","timestamp":1777564581000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/33\/1\/83\/8328419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,25]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["612"],"URL":"https:\/\/doi.org\/10.1007\/s40620-019-00612-3","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,25]]},"assertion":[{"value":"24 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by Institutional Ethical Committee of the \u201cPoliclinico Tor Vergata.\u201dExperimental procedures here reported were performed in agreement with the The Code (n\u00b054\/14) of Ethics of the World Medical Association (Declaration of Helsinki).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"This study was approved and conducted in accordance with the guidelines of the Human Research Committee of \"Fondazione Policlinico Tor Vergata\" (n\u00b054\/14).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Each subject signed an informed consent before surgery.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}