{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:11:30Z","timestamp":1792098690596,"version":"4.4.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T00:00:00Z","timestamp":1565395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T00:00:00Z","timestamp":1565395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Laboratoris Sanifit"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s40620-019-00631-0","type":"journal-article","created":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T14:02:37Z","timestamp":1565445757000},"page":"811-821","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Improvement in wound healing, pain, and quality of life after 12 weeks of SNF472 treatment: a phase 2 open-label study of patients with calciphylaxis"],"prefix":"10.1093","volume":"32","author":[{"given":"Vincent M.","family":"Brandenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smeeta","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose-Vicente","family":"Torregrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Zeralda","family":"Canals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daun","family":"Bahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter H.","family":"Joubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Salcedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Perell\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,10]]},"reference":[{"key":"631_CR1","doi-asserted-by":"publisher","first-page":"701603","DOI":"10.4061\/2011\/701603","volume":"2011","author":"SK Goel","year":"2011","unstructured":"Goel SK, Bellovich K, McCullough PA (2011) Treatment of severe metastatic calcification and calciphylaxis in dialysis patients. Int J Nephrol 2011:701603. https:\/\/doi.org\/10.4061\/2011\/701603","journal-title":"Int J Nephrol"},{"key":"631_CR2","unstructured":"Nunley JR (2017) Calciphylaxis. https:\/\/emedicine.medscape.com\/article\/1095481-overview . Accessed 1 June 2019"},{"key":"631_CR3","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/nrneph.2009.99","volume":"5","author":"G Schlieper","year":"2009","unstructured":"Schlieper G, Brandenburg V, Ketteler M, Floege J (2009) Sodium thiosulfate in the treatment of calcific uremic arteriolopathy. Nat Rev Nephrol 5:539\u2013543. https:\/\/doi.org\/10.1038\/nrneph.2009.99","journal-title":"Nat Rev Nephrol"},{"key":"631_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s40620-015-0192-2","volume":"28","author":"TM Oliveira","year":"2015","unstructured":"Oliveira TM, Frazao JM (2015) Calciphylaxis: from the disease to the diseased. J Nephrol 28:531\u2013540. https:\/\/doi.org\/10.1007\/s40620-015-0192-2","journal-title":"J Nephrol"},{"key":"631_CR5","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/S0039-6060(97)90212-9","volume":"122","author":"M Angelis","year":"1997","unstructured":"Angelis M, Wong LL, Myers SA, Wong LM (1997) Calciphylaxis in patients on hemodialysis: a prevalence study. Surgery 122:1083\u20131089. https:\/\/doi.org\/10.1016\/S0039-6060(97)90212-9 (discussion 1089\u20131090)","journal-title":"Surgery"},{"key":"631_CR6","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1681\/ASN.V77978","volume":"7","author":"MN Budisavljevic","year":"1996","unstructured":"Budisavljevic MN, Cheek D, Ploth DW (1996) Calciphylaxis in chronic renal failure. J Am Soc Nephrol 7:978\u2013982","journal-title":"J Am Soc Nephrol"},{"key":"631_CR7","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1056\/NEJMra1505292","volume":"378","author":"SU Nigwekar","year":"2018","unstructured":"Nigwekar SU, Thadhani R, Brandenburg VM (2018) Calciphylaxis. N Engl J Med 378:1704\u20131714. https:\/\/doi.org\/10.1056\/NEJMra1505292","journal-title":"N Engl J Med"},{"key":"631_CR8","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/ndt\/gfv438","volume":"32","author":"VM Brandenburg","year":"2017","unstructured":"Brandenburg VM, Kramann R, Rothe H, Kaesler N, Korbiel J, Specht P, Schmitz S, Kr\u00fcger T, Floege J, Ketteler M (2017) Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry. Nephrol Dial Transplant 32:126\u2013132. https:\/\/doi.org\/10.1093\/ndt\/gfv438","journal-title":"Nephrol Dial Transplant"},{"key":"631_CR9","first-page":"38","volume":"5","author":"A Sanguankeo","year":"2017","unstructured":"Sanguankeo A, Thamcharoen N, Upala S (2017) Calciphylaxis in a nondialysis patient treated with sodium thiosulfate and high dose of oxygen. Clin Nephrol Case Stud 5:38\u201341","journal-title":"Clin Nephrol Case Stud"},{"key":"631_CR10","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1097\/DAD.0b013e31827c7f5d","volume":"35","author":"MC Mochel","year":"2013","unstructured":"Mochel MC, Arakaki RY, Wang G, Kroshinsky D, Hoang MP (2013) Cutaneous calciphylaxis: a retrospective histopathologic evaluation. Am J Dermatopathol 35:582\u2013586. https:\/\/doi.org\/10.1097\/DAD.0b013e31827c7f5d","journal-title":"Am J Dermatopathol"},{"key":"631_CR11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1053\/j.ajkd.2015.01.034","volume":"66","author":"SU Nigwekar","year":"2015","unstructured":"Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI (2015) Calciphylaxis: risk factors, diagnosis, and treatment. Am J Kidney Dis 66:133\u2013146. https:\/\/doi.org\/10.1053\/j.ajkd.2015.01.034","journal-title":"Am J Kidney Dis"},{"key":"631_CR12","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/0190-9622(95)90286-4","volume":"33","author":"J Hafner","year":"1995","unstructured":"Hafner J, Keusch G, Wahl C, Sauter B, Hurlimann A, von Weizsacker F, Krayenbuhl M, Biedermann K, Brunner U, Helfenstein U (1995) Uremic small-artery disease with medial calcification and intimal hyperplasia (so-called calciphylaxis): a complication of chronic renal failure and benefit from parathyroidectomy. J Am Acad Dermatol 33:954\u2013962","journal-title":"J Am Acad Dermatol"},{"key":"631_CR13","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1046\/j.1523-1755.2002.00375.x","volume":"61","author":"A Fine","year":"2002","unstructured":"Fine A, Zacharias J (2002) Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int 61:2210\u20132217. https:\/\/doi.org\/10.1046\/j.1523-1755.2002.00375.x","journal-title":"Kidney Int"},{"key":"631_CR14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jaad.2006.08.065","volume":"56","author":"RH Weenig","year":"2007","unstructured":"Weenig RH, Sewell LD, Davis MD, McCarthy JT, Pittelkow MR (2007) Calciphylaxis: natural history, risk factor analysis, and outcome. J Am Acad Dermatol 56:569\u2013579. https:\/\/doi.org\/10.1016\/j.jaad.2006.08.065","journal-title":"J Am Acad Dermatol"},{"key":"631_CR15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2165\/11587060-000000000-00000","volume":"12","author":"M Auriemma","year":"2011","unstructured":"Auriemma M, Carbone A, Di Liberato L, Cupaiolo A, Caponio C, De Simone C, Tulli A, Bonomini M, Amerio P (2011) Treatment of cutaneous calciphylaxis with sodium thiosulfate: two case reports and a review of the literature. Am J Clin Dermatol 12:339\u2013346. https:\/\/doi.org\/10.2165\/11587060-000000000-00000","journal-title":"Am J Clin Dermatol"},{"key":"631_CR16","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.2215\/CJN.09880912","volume":"8","author":"SU Nigwekar","year":"2013","unstructured":"Nigwekar SU, Brunelli SM, Meade D, Wang W, Hymes J, Lacson E Jr (2013) Sodium thiosulfate therapy for calcific uremic arteriolopathy. Clin J Am Soc Nephrol 8:1162\u20131170. https:\/\/doi.org\/10.2215\/CJN.09880912","journal-title":"Clin J Am Soc Nephrol"},{"key":"631_CR17","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/nep.13081","volume":"23","author":"T Peng","year":"2018","unstructured":"Peng T, Zhuo L, Wang Y, Jun M, Li G, Wang L, Hong D (2018) Systematic review of sodium thiosulfate in treating calciphylaxis in chronic kidney disease patients. Nephrology (Carlton) 23:669\u2013675. https:\/\/doi.org\/10.1111\/nep.13081","journal-title":"Nephrology (Carlton)"},{"key":"631_CR18","doi-asserted-by":"publisher","first-page":"e0197061","DOI":"10.1371\/journal.pone.0197061","volume":"13","author":"MD Ferrer","year":"2018","unstructured":"Ferrer MD, Ketteler M, Tur F, Tur E, Isern B, Salcedo C, Joubert PH, Behets GJ, Neven E, D\u2019Haese PC, Perello J (2018) Characterization of SNF472 pharmacokinetics and efficacy in uremic and non-uremic rats models of cardiovascular calcification. PLoS ONE 13:e0197061. https:\/\/doi.org\/10.1371\/journal.pone.0197061","journal-title":"PLoS ONE"},{"key":"631_CR19","doi-asserted-by":"publisher","first-page":"6858","DOI":"10.1038\/s41598-017-07203-x","volume":"7","author":"MD Ferrer","year":"2017","unstructured":"Ferrer MD, Perez MM, Canaves MM, Buades JM, Salcedo C, Perello J (2017) A novel pharmacodynamic assay to evaluate the effects of crystallization inhibitors on calcium phosphate crystallization in human plasma. Sci Rep 7:6858. https:\/\/doi.org\/10.1038\/s41598-017-07203-x","journal-title":"Sci Rep"},{"key":"631_CR20","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s40620-018-0471-9","volume":"31","author":"J Perell\u00f3","year":"2018","unstructured":"Perell\u00f3 J, G\u00f3mez M, Ferrer MD, Rodr\u00edguez NY, Salcedo C, Buades JM, P\u00e9rez MM, Torregrosa JV, Mart\u00edn E, Maduell F (2018) SNF472, a novel inhibitor of vascular calcification, could be administered during hemodialysis to attain potentially therapeutic phytate levels. J Nephrol 31:287\u2013296. https:\/\/doi.org\/10.1007\/s40620-018-0471-9","journal-title":"J Nephrol"},{"key":"631_CR21","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1111\/bcp.13752","volume":"84","author":"J Perell\u00f3","year":"2018","unstructured":"Perell\u00f3 J, Joubert PH, Ferrer MD, Canals AZ, Sinha S, Salcedo C (2018) First-time-in-human randomized clinical trial in healthy volunteers and haemodialysis patients with SNF472, a novel inhibitor of vascular calcification. Br J Clin Pharmacol 84:2867\u20132876. https:\/\/doi.org\/10.1111\/bcp.13752","journal-title":"Br J Clin Pharmacol"},{"key":"631_CR22","first-page":"20","volume":"5","author":"BM Bates-Jensen","year":"1992","unstructured":"Bates-Jensen BM, Vredevoe DL, Brecht ML (1992) Validity and reliability of the pressure sore status tool. Decubitus 5:20\u201328","journal-title":"Decubitus"},{"key":"631_CR23","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1111\/iwj.12803","volume":"14","author":"M Augustin","year":"2017","unstructured":"Augustin M, Baade K, Heyer K, Price PE, Herberger K, Wild T, Engelhardt M, Debus ES (2017) Quality-of-life evaluation in chronic wounds: comparative analysis of three disease-specific questionnaires. Int Wound J 14:1299\u20131304. https:\/\/doi.org\/10.1111\/iwj.12803","journal-title":"Int Wound J"},{"key":"631_CR24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jclinepi.2018.05.007","volume":"101","author":"MF Olsen","year":"2018","unstructured":"Olsen MF, Bjerre E, Hansen MD, Tendal B, Hilden J, Hr\u00f3bjartsson A (2018) Minimum clinically important differences in chronic pain vary considerably by baseline pain and methodological factors: systematic review of empirical studies. J Clin Epidemiol 101:87\u2013106.e2. https:\/\/doi.org\/10.1016\/j.jclinepi.2018.05.007","journal-title":"J Clin Epidemiol"},{"key":"631_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12916-016-0775-3","volume":"15","author":"MF Olsen","year":"2017","unstructured":"Olsen MF, Bjerre E, Hansen MD, Hilden J, Landler NE, Tendal B, Hr\u00f3bjartsson A (2017) Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain. BMC Med 15:35. https:\/\/doi.org\/10.1186\/s12916-016-0775-3","journal-title":"BMC Med"},{"key":"631_CR26","first-page":"288","volume":"30","author":"JV Torregrosa","year":"2010","unstructured":"Torregrosa JV, Ramos AM (2010) Use of bisphosphonates in chronic kidney disease. Nefrologia 30:288\u2013296","journal-title":"Nefrologia"},{"key":"631_CR27","first-page":"329","volume":"32","author":"JV Torregrosa","year":"2012","unstructured":"Torregrosa JV, Duran CE, Barros X, Blasco M, Arias M, Cases A, Campistol JM (2012) Successful treatment of calcific uraemic arteriolopathy with bisphosphonates. Nefrologia 32:329\u2013334","journal-title":"Nefrologia"},{"key":"631_CR28","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.amjms.2015.11.015","volume":"351","author":"HS Jeong","year":"2016","unstructured":"Jeong HS, Dominguez AR (2016) Calciphylaxis: controversies in pathogenesis, diagnosis and treatment. Am J Med Sci 351:217\u2013227. https:\/\/doi.org\/10.1016\/j.amjms.2015.11.015","journal-title":"Am J Med Sci"},{"key":"631_CR29","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1111\/bjd.15702","volume":"177","author":"CA Riemer","year":"2017","unstructured":"Riemer CA, El-Azhary RA, Wu KL, Strand JJ, Lehman JS (2017) Underreported use of palliative care and patient-reported outcome measures to address reduced quality of life in patients with calciphylaxis: a systematic review. Br J Dermatol 177:1510\u20131518. https:\/\/doi.org\/10.1111\/bjd.15702","journal-title":"Br J Dermatol"},{"key":"631_CR30","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/j.1525-139X.2010.00738.x","volume":"23","author":"MR Hayden","year":"2010","unstructured":"Hayden MR, Goldsmith DJ (2010) Sodium thiosulfate: new hope for the treatment of calciphylaxis. Semin Dial 23:258\u2013262. https:\/\/doi.org\/10.1111\/j.1525-139X.2010.00738.x","journal-title":"Semin Dial"},{"key":"631_CR31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000380945","volume":"5","author":"Z Yu","year":"2015","unstructured":"Yu Z, Gu L, Pang H, Fang Y, Yan H, Fang W (2015) Sodium thiosulfate: an emerging treatment for calciphylaxis in dialysis patients. Case Rep Nephrol Dial 5:77\u201382. https:\/\/doi.org\/10.1159\/000380945","journal-title":"Case Rep Nephrol Dial"},{"key":"631_CR32","doi-asserted-by":"publisher","first-page":"800","DOI":"10.2215\/CJN.10221014","volume":"10","author":"J Floege","year":"2015","unstructured":"Floege J, Kubo Y, Floege A, Chertow GM, Parfrey PS (2015) The effect of cinacalcet on calcific uremic arteriolopathy events in patients receiving hemodialysis: the EVOLVE trial. Clin J Am Soc Nephrol 10:800\u2013807. https:\/\/doi.org\/10.2215\/CJN.10221014","journal-title":"Clin J Am Soc Nephrol"},{"key":"631_CR33","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1093\/ckj\/sfv120","volume":"9","author":"D Russo","year":"2016","unstructured":"Russo D, Capuano A, Cozzolino M, Napolitano P, Mosella F, Russo L, Saviano C, Zoccali C (2016) Multimodal treatment of calcific uraemic arteriolopathy (calciphylaxis): a case series. Clin Kidney J 9:108\u2013112. https:\/\/doi.org\/10.1093\/ckj\/sfv120","journal-title":"Clin Kidney J"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-019-00631-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40620-019-00631-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-019-00631-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:56:17Z","timestamp":1777564577000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/32\/5\/811\/8328205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,10]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["631"],"URL":"https:\/\/doi.org\/10.1007\/s40620-019-00631-0","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,10]]},"assertion":[{"value":"30 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"VB is a consultant to Pharmacosmos, Vifor, and FMC, received lecture fees from Amgen, Pfizer, Bayer, Pharmacosmos, Vifor, FMC, Servier, Novartis, Daiichi-Sankyo, and Cardiobridge, received a grant for the European Calciphylaxis Network EuCalNet from Amgen, and received grants from Pfizer, Bayer, Sanifit, Pharmacosmos, Vifor, FMC, Servier, Novartis, Daiichi-Sankyo, and Cardiobridge. SS is a consultant to Sanifit, and received lecture fees from Vifor Fresenius, MSD, and Boehringer Ingelheim. JT has no conflicts to disclose. KJC and PJ, are consultants to Sanifit. RG, SM and AG are employees and shareholders of Sanifit Therapeutics. AZC is an employee and shareholders of Sanifit and has a patent pending related to SNF472. CS is an employee of Sanifit and has patents related to SNF472. JP is an employee and shareholder of Sanifit, and has patents owned or controlled by Sanifit.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Patients gave written informed consent to participate.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}