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PM function is evaluated by the peritoneal equilibration test (PET), a tedious technique only detecting alterations in extensively damaged PM. In a previous study, we showed that peritoneal dialysis effluent contained extracellular vesicles (PDE-EV), and that their proteome was significantly different between newly enrolled and long-term PD patients. Here, we report the results of a longitudinal study and compare PDE-EV proteome changes with PET results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PDE was collected from 11 patients every 6\u00a0months (coincident with PET controls) from 0\u00a0months up to 24\u00a0months on PD. PDE-EV were isolated by size-exclusion chromatography and the proteome was analyzed by mass spectrometry (LC\u2013MS\/MS). Bioinformatic analyses were conducted to evaluate differences between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At follow-up endpoint, patients were classified as Stable (n\u2009=\u20097) or Unstable (n\u2009=\u20094) according to PET evolution. Strikingly, PDE-EV from the Stable group showed a significantly higher protein expression compared to Unstable patients already at 6\u00a0months on PD, when PET alterations had not been detected yet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PDE-EV proteome show alterations much earlier than PET monitoring, thus unveiling the potential of PDE-EV proteins as feasible biomarkers of PM alteration in PD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-019-00658-3","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T07:15:02Z","timestamp":1571123702000},"page":"1021-1031","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Proteomic profiling of peritoneal dialysis effluent-derived extracellular vesicles: a longitudinal 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