{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:30:54Z","timestamp":1781731854692,"version":"3.54.5"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR1368"],"award-info":[{"award-number":["FOR1368"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006254","name":"Ruhr-Universit\u00e4t Bochum","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006254","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dickkopf-3 (DKK3) has recently been discovered as a urinary biomarker for the prediction of acute kidney injury (AKI) after cardiac surgery. This finding needs to be confirmed for AKI in other clinical settings. The present study investigates whether DKK3 can predict contrast-induced AKI (CI-AKI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a prospective study in 490 patients undergoing coronary angiography. Primary endpoint was an increase in serum creatinine concentration\u2009\u2265\u20090.3\u00a0mg\/dl within 72\u00a0h after the procedure. DKK3 was assessed\u2009&lt;\u200924\u00a0h before coronary angiography. Predictive accuracy was assessed by receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CI-AKI was observed in 30 (6.1%) patients, of whom 27 corresponded to stage I and 3 to stage II according to the Acute Kidney Injury Network (AKIN) criteria. Subjects who developed CI-AKI had a 3.8-fold higher urinary DKK3\/creatinine ratio than those without CI-AKI (7.5\u00a0pg\/mg [interquartile range [IQR] 1.2\u20131392.0] vs. 2.0\u00a0pg\/mg [IQR 0.9\u2013174.0]; p\u2009=\u20090.047). ROC analysis revealed an area under the curve (AUC) of 0.61. Among subjects without clinically overt chronic kidney disease (estimated glomerular filtration rate [eGFR]\u2009&gt;\u200960\u00a0ml\/min, urinary albumin creatinine ratio\u2009&lt;\u200930\u00a0mg\/g), the DKK3\/creatinine ratio was 5.4-fold higher in those with subsequent CI-AKI (7.5\u00a0pg\/mg [IQR 0.9\u2013590.1] vs. 1.38\u00a0pg\/mg [IQR 0.8\u201351.0];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007; AUC 0.62). Coronary angiography was associated with a 43 times increase in the urinary DKK3\/creatinine ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Urinary DKK3 is an independent predictor of CI-AKI even in the absence of overt chronic kidney disease (CKD). The study thereby expands the findings on DKK3 in the prediction of postoperative loss of kidney function to other entities of AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphic abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-020-00910-1","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T11:03:12Z","timestamp":1607079792000},"page":"821-828","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Dickkopf-3 in the prediction of contrast media induced acute kidney injury"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-2481","authenticated-orcid":false,"given":"Felix S.","family":"Seibert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Heringhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Pagonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Rohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Trappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Babel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm H.","family":"Westhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"issue":"1","key":"910_CR1","doi-asserted-by":"publisher","first-page":"e84916","DOI":"10.1172\/jci.insight.84916","volume":"1","author":"G Federico","year":"2016","unstructured":"Federico G, Meister M, Mathow D, Heine GH, Moldenhauer G, Popovic ZV, Nordstrom V, Kopp-Schneider A, Hielscher T, Nelson PJ, Schaefer F, Porubsky S, Fliser D, Arnold B, Grone HJ (2016) Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis. JCI Insight 1(1):e84916. https:\/\/doi.org\/10.1172\/jci.insight.84916","journal-title":"JCI Insight"},{"issue":"11","key":"910_CR2","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1681\/ASN.2018040405","volume":"29","author":"S Zewinger","year":"2018","unstructured":"Zewinger S, Rauen T, Rudnicki M, Federico G, Wagner M, Triem S, Schunk SJ, Petrakis I, Schmit D, Wagenpfeil S, Heine GH, Mayer G, Floege J, Fliser D, Grone HJ, Speer T (2018) Dickkopf-3 (DKK3) in urine identifies patients with short-term risk of eGFR loss. J Am Soc Nephrol 29(11):2722\u20132733. https:\/\/doi.org\/10.1681\/ASN.2018040405","journal-title":"J Am Soc Nephrol"},{"issue":"10197","key":"910_CR3","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/S0140-6736(19)30769-X","volume":"394","author":"SJ Schunk","year":"2019","unstructured":"Schunk SJ, Zarbock A, Meersch M, Kullmar M, Kellum JA, Schmit D, Wagner M, Triem S, Wagenpfeil S, Grone HJ, Schafers HJ, Fliser D, Speer T, Zewinger S (2019a) Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study. Lancet 394(10197):488\u2013496. https:\/\/doi.org\/10.1016\/S0140-6736(19)30769-X","journal-title":"Lancet"},{"key":"910_CR4","first-page":"1","volume":"3","author":"Kidney Disease Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO","year":"2012","unstructured":"Kidney Disease Improving Global Outcomes (KDIGO) CKD Work Group. 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