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Surgical pathologists primarily focus on tumor diagnosis and investigations relating to prognosis or therapy. Pathological changes in non-neoplastic tissue may, however, be relevant for further management and should be thoroughly assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we examined the non-neoplastic renal parenchyma in 206 tumor nephrectomy specimens for the presence of glomerular, tubulo-interstitial, or vascular\u00a0lesions, and correlated them with clinical parameters and outcome of renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed\u00a0188 malignant and 18 benign or pseudo-tumorous lesions. The most common tumor type was clear cell renal cell carcinoma (CCRCC, n\u2009=\u2009106) followed by papillary or urothelial carcinomas (n\u2009=\u200925). Renal pathology examination revealed the presence of\u00a0kidney disease in 39 cases (18.9%). Glomerulonephritis\u00a0was found in 15 cases (7.3%), and the most\u00a0frequent was IgA nephropathy (n\u2009=\u20096; 2.9%). Vasculitis was found in two cases\u00a0(0.9%). In 15 cases we found tubulo-interstitial nephritis, and in 9 severe diabetic or hypertensive nephropathy. Partial nephrectomy was not linked to better eGFR at follow-up. Age, vascular nephropathy, glomerular scarring and interstitial fibrosis were the leading independent negative factors influencing eGFR at time of surgery, whereas proteinuria was associated\u00a0with\u00a0reduced\u00a0eGFR at 1\u00a0year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our large study population indicates a high incidence of renal diseases potentially\u00a0relevant for\u00a0the postoperative management of patients with renal neoplasia. Consistent and systematic reporting of non-neoplastic renal pathology in tumor nephrectomy specimens should therefore be mandatory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-021-01030-0","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T07:03:10Z","timestamp":1619420590000},"page":"1833-1844","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["More than ancillary records: clinical implications of renal pathology examination in tumor nephrectomy specimens"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-0713","authenticated-orcid":false,"given":"Johannes Philipp","family":"Kl\u00e4ger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6540-6974","authenticated-orcid":false,"given":"Ahmad","family":"Al-Taleb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-8257","authenticated-orcid":false,"given":"Mladen","family":"Pavlovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-7981","authenticated-orcid":false,"given":"Andrea","family":"Haitel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8488-543X","authenticated-orcid":false,"given":"Eva","family":"Comperat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"Fajkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0093-5389","authenticated-orcid":false,"given":"\u017deljko","family":"Kiki\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-543X","authenticated-orcid":false,"given":"Renate","family":"Kain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-620X","authenticated-orcid":false,"given":"Nicolas","family":"Kozakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"1030_CR1","unstructured":"ECIS European Cancer Information System (2020) Estimates of cancer incidence and mortality in 2018, for all cancer sites. https:\/\/ecis.jrc.ec.europa.eu\/index.php. 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