{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:43:16Z","timestamp":1791420196405,"version":"4.3.3"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s40620-021-01125-8","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T11:03:02Z","timestamp":1629802982000},"page":"317-321","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["COVID-19-associated atypical hemolytic uremic syndrome and use of Eculizumab therapy"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-0610","authenticated-orcid":false,"given":"Jasmeet","family":"Gill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Alan","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gates Burton","family":"Colbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"1125_CR1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.kint.2020.05.013","volume":"98","author":"M Noris","year":"2020","unstructured":"Noris M, Benigni A, Remuzzi G (2020) The case of complement activation in COVID-19 multiorgan impact. Kidney Int 98:314\u2013322","journal-title":"Kidney Int"},{"issue":"1","key":"1125_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.kint.2020.05.006","volume":"98","author":"JS Hirsch","year":"2020","unstructured":"Hirsch JS, Ng JH, Ross DW, Sharma P, Shah HH, Barnett RL et al (2020) Acute kidney injury in patients hospitalized with COVID-19. Kidney Int 98(1):209\u2013218","journal-title":"Kidney Int"},{"issue":"7","key":"1125_CR3","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1681\/ASN.2020040419","volume":"31","author":"D Batlle","year":"2020","unstructured":"Batlle D, Soler MJ, Sparks MA, Hiremath S, South AM, Welling PA, Swaminathan S (2020) Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology. J Am Soc Nephrol 31(7):1380\u20131383","journal-title":"J Am Soc Nephrol"},{"key":"1125_CR4","doi-asserted-by":"crossref","unstructured":"Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY et al (2020) Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 98(1):219\u2013227","DOI":"10.1016\/j.kint.2020.04.003"},{"key":"1125_CR5","first-page":"221","volume":"9","author":"B Diao","year":"2020","unstructured":"Diao B, Feng Z, Wang C, Wang H, Liu L, Wang C et al (2020) Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. MedRxiv. 9:221","journal-title":"MedRxiv."},{"issue":"10","key":"1125_CR6","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1086\/429631","volume":"191","author":"WE Ip","year":"2005","unstructured":"Ip WE, Chan KH, Law HK, Tso GH, Kong EK, Wong WH et al (2005) Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. J Infect Dis 191(10):1697\u20131704","journal-title":"J Infect Dis"},{"key":"1125_CR7","doi-asserted-by":"crossref","unstructured":"Gao T, Hu M, Zhang X, Li H, Zhu L, Liu H et al (2020) Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation. MedRxiv","DOI":"10.1101\/2020.03.29.20041962"},{"key":"1125_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2020.04.007","volume":"220","author":"C Magro","year":"2020","unstructured":"Magro C, Mulvey JJ, Berlin D et al (2020) Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. Transl Res 220:1\u201313. https:\/\/doi.org\/10.1016\/j.trsl.2020.04.007","journal-title":"Transl Res"},{"issue":"5","key":"1125_CR9","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01753-18","volume":"9","author":"LE Gralinski","year":"2018","unstructured":"Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS (2018) Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis. MBio 9(5):e01753-18. https:\/\/doi.org\/10.1128\/mBio.01753-18","journal-title":"MBio"},{"issue":"7","key":"1125_CR10","first-page":"4040","volume":"24","author":"F Diurno","year":"2020","unstructured":"Diurno F, Numis FG, Porta G, Cirillo F, Maddaluno S, Ragozzino A, De Negri P, Di Gennaro C, Pagano A, Allegorico E, Bressy L, Bosso G, Ferrara A, Serra C, Montisci A, D\u2019Amico M, Schiano Lo Morello S, Di Costanzo G, Tucci AG, Marchetti P et al (2020) Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience. Eur Rev Med Pharmacol Sci 24(7):4040\u20134047","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"1125_CR11","doi-asserted-by":"publisher","first-page":"e2020016774","DOI":"10.1542\/peds.2020-016774","volume":"147","author":"F Alizadeh","year":"2021","unstructured":"Alizadeh F, O\u2019Halloran A, Alghamdi A, Chen C, Trissal M, Traum A, DeCourcey D (2021) Toddler with new onset diabetes and atypical hemolytic-uremic syndrome in the setting of COVID-19. Pediatrics 147(2):e2020016774","journal-title":"Pediatrics"},{"issue":"6","key":"1125_CR12","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s40620-020-00858-2","volume":"33","author":"R Mahajan","year":"2020","unstructured":"Mahajan R, Lipton M, Broglie L, Jain NG, Uy NS (2020) Eculizumab treatment for renal failure in a pediatric patient with COVID-19. J Nephrol 33(6):1373\u20131376","journal-title":"J Nephrol"},{"issue":"4","key":"1125_CR13","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1093\/ckj\/sfab024","volume":"14","author":"S Safak","year":"2021","unstructured":"Safak S, Aksoy E, Dirim AB, Demir E, Garayeva N, Oto OA et al (2021) Successful treatment of a COVID-19 patient with thrombotic microangiopathy. Clin Kidney J 14(4):1287\u20131288","journal-title":"Clin Kidney J"},{"issue":"2","key":"1125_CR14","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.kint.2020.05.025","volume":"98","author":"KD Jhaveri","year":"2020","unstructured":"Jhaveri KD, Meir LR, Chang BSF, Parikh R, Wanchoo R, Barilla-LaBarca ML et al (2020) Thrombotic microangiopathy in a patient with COVID-19. Kidney Int 98(2):509\u2013512","journal-title":"Kidney Int"},{"issue":"10","key":"1125_CR15","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1111\/j.1600-6143.2005.01047.x","volume":"5","author":"H Sartelet","year":"2005","unstructured":"Sartelet H, Toupance O, Lorenzato M, Fadel F, Noel LH, Lagonotte E, Birembaut P, Chanard J, Rieu P (2005) Sirolimus-induced thrombotic microangiopathy is associated with decreased expression of vascular endothelial growth factor in kidneys. Am J Transplant 5(10):2441\u20132447. https:\/\/doi.org\/10.1111\/j.1600-6143.2005.01047.x","journal-title":"Am J Transplant"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-021-01125-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-021-01125-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-021-01125-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:58:47Z","timestamp":1777564727000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/35\/1\/317\/8439594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["1125"],"URL":"https:\/\/doi.org\/10.1007\/s40620-021-01125-8","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,24]]},"assertion":[{"value":"12 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No conflicts of interest, financial or other, exist.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this type of article formal informed consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Yes.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}