{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:07:19Z","timestamp":1786982839692,"version":"build-2736575974"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neonatal Acute kidney injury (AKI) is an underestimated morbidity in the neonatal intensive care unit (ICU). However, there is a paucity of information about risk factors, outcomes, and possible preventive measures to limit its occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to determine the prevalence of neonatal AKI in a neonatal ICU. Data obtained from this study will help to better understand current local practices and investigate possible preventive strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Charts from January 2011 to December 2018 were reviewed. Neonates less than 2\u00a0weeks old who depended on intravenous fluid as a nutrition source for at least two days were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, the eight-year prevalence of neonatal AKI in the neonatal\u00a0ICU\u00a0was 19.6%, and severity was distributed as follows: stage 1 (46.2%), stage 2 (26.5%), and stage 3 (27.3%). Caffeine administration before 29\u00a0weeks\u2019 gestational age significantly decreased the incidence of neonatal AKI. The incidence of neonatal AKI was independently associated with death (odds ratios (OR)\u2009=\u20097.11,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and extended length of hospital stay (OR\u2009=\u20092.47,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the multivariate regression model, vancomycin (AOR\u2009=\u20091.637,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.004), loop diuretics (AOR\u2009=\u20092.203,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), intraventricular hemorrhage (AOR\u2009=\u20092.605,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), surgical intervention (AOR\u2009=\u20091.566,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.008), mechanical ventilation (AOR\u2009=\u20091.463,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.015), and dopamine administration (AOR\u2009=\u20092.399,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independently associated with neonatal AKI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neonatal AKI occurred in one-fifth of the study population\u00a0in a neonatal ICU. Outcomes can be improved by identifying high-risk infants and cautiously monitoring kidney function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-021-01130-x","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T06:05:31Z","timestamp":1630476331000},"page":"1659-1668","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prediction of risk factors and outcomes of neonatal acute kidney injury"],"prefix":"10.1093","volume":"34","author":[{"given":"Kumail","family":"AlGadeeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Qaraqei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahma","family":"Algadeeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Faqeehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-4943","authenticated-orcid":false,"given":"Abdulrahman","family":"Al-Matary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"issue":"2","key":"1130_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00467-008-1060-2","volume":"24","author":"DJ Askenazi","year":"2009","unstructured":"Askenazi DJ, Ambalavanan N, Goldstein SL (2009) Acute kidney injury in critically ill newborns: what do we know? 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