{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:48:31Z","timestamp":1769057311281,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystogenesis in polycystic kidney disease (PKD) is likely accelerated by various renal insults, including crystal deposition, that activate renal tubule obstruction and dilation. We developed a capsule-based device that can be applied to cystic kidneys to restrict tubular lumen dilatation and cyst expansion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Kidney capsule devices were designed from computed tomography images of wild-type and Cy\/+\u2009rats. Capsule devices were surgically implanted on kidneys in six surgical sessions over a period of 14\u00a0months in 7 wild-type rats of 6.5\u20138\u00a0weeks (3 sham operations, 2 right, 2 left) and 6 Cy\/+\u2009rats of 6.5\u00a0weeks (2 sham, 3 left, 1 bilateral). After surgery, the rats were followed for 5.4\u201312.4\u00a0weeks\u2019 growth and sacrificed to retrieve the kidneys. During the follow-up, serum creatinine was measured and retrieved kidneys were weighed. Histological analysis including cystic area measurement and immunohistochemistry was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Morphometric capsule devices were configured and developed by an image processing technique and produced using a 3D printer. Encapsulated Cy\/+\u2009kidneys (n\u2009=\u20095; mean weight 3.64\u00a0g) were consistently smaller in size (by 21\u201336%; p\u2009&amp;lt;\u20090.001) than unencapsulated Cy\/+\u2009kidneys (n\u2009=\u20097; mean weight 5.52\u00a0g). Encapsulated Cy\/+\u2009kidneys (mean %cyst area: 29.4%) showed smaller histological cystic area (by 28\u201358%; p\u2009&amp;lt;\u20090.001) than unencapsulated Cy\/+\u2009kidneys (mean %cyst area 48.6%). Cell proliferation and macrophages were also markedly reduced in encapsulated Cy\/+\u2009kidneys, compared to unencapsulated Cy\/+\u2009kidneys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We report a pilot feasibility study for the application of a novel morphometric 3D capsule device to the Cy\/+\u2009rat model showing restricted kidney volume expansion on polycystic kidney disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-021-01160-5","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T08:02:39Z","timestamp":1636531359000},"page":"1033-1040","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel 3D capsule device to restrict kidney volume expansion on polycystic kidney progression: feasibility study in a rat model"],"prefix":"10.1093","volume":"35","author":[{"given":"Kyongtae T.","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Pittsburgh School of Medicine, 300 Halket St. Suite C-316, 15213, Pittsburgh, PA, USA 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Kumamoto","sequence":"additional","affiliation":[{"name":"Education and Research Facility of Animal Models for Human Diseases, Center for Research Promotion and Support, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoke, 470-1192, Aichi, Japan 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Education and Research Facility of Animal Models for Human Diseases, Center for Research Promotion and Support, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoke, 470-1192, Aichi, Japan 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Kugita","sequence":"additional","affiliation":[{"name":"Education and Research Facility of Animal Models for Human Diseases, Center for Research Promotion and Support, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoke, 470-1192, Aichi, Japan 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Urology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamio","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie, Japan 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junu T.","family":"Bae","sequence":"additional","affiliation":[{"name":"Ohio State University College of Medicine, Columbus, OH, USA 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuko","family":"Nagao","sequence":"additional","affiliation":[{"name":"Education and Research Facility of Animal Models for Human Diseases, Center for Research Promotion and Support, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoke, 470-1192, Aichi, Japan 2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"2026012108022147000_CR1","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1056\/NEJMoa1710030","article-title":"Tolvaptan in later-stage autosomal dominant polycystic kidney disease","volume":"377","author":"Torres","year":"2017","journal-title":"N Engl J Med"},{"key":"2026012108022147000_CR2","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1056\/NEJMcp0804458","article-title":"Clinical practice. Autosomal dominant polycystic kidney disease","volume":"359","author":"Grantham","year":"2008","journal-title":"N Engl J Med"},{"key":"2026012108022147000_CR3","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1002\/jcp.26222","article-title":"Comprehensive transcriptome analysis of fluid shear stress altered gene expression in renal epithelial cells","volume":"233","author":"Kunnen","year":"2018","journal-title":"J Cell Physiol"},{"key":"2026012108022147000_CR4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nature21407","article-title":"Mechanical stretch triggers rapid epithelial cell division through Piezo1","volume":"543","author":"Gudipaty","year":"2017","journal-title":"Nature"},{"key":"2026012108022147000_CR5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/sj.ki.5002629","article-title":"Calcium channel inhibition accelerates polycystic kidney disease progression in the Cy\/+ rat","volume":"73","author":"Nagao","year":"2008","journal-title":"Kidney Int"},{"key":"2026012108022147000_CR6","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.1681\/ASN.2005060601","article-title":"Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy\/+) rat","volume":"16","author":"Brown","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2026012108022147000_CR7","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1148\/rg.2015140320","article-title":"Medical 3D printing for the radiologist","volume":"35","author":"Mitsouras","year":"2015","journal-title":"Radiographics"},{"key":"2026012108022147000_CR8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11302-007-9072-0","article-title":"Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals","volume":"4","author":"Hovater","year":"2008","journal-title":"Purinergic Signal"},{"key":"2026012108022147000_CR9","first-page":"199","article-title":"Regulation of cellular ATP release","volume":"118","author":"Fitz","year":"2007","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"2026012108022147000_CR10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1046\/j.1523-1755.2003.00755.x","article-title":"Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease","volume":"63","author":"Nagao","year":"2003","journal-title":"Kidney Int"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-021-01160-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-021-01160-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/35\/3\/1033\/66018831\/joneph_35_3_1160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-021-01160-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/35\/3\/1033\/66018831\/joneph_35_3_1160.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:02:27Z","timestamp":1769000547000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/35\/3\/1033\/8325997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,10]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,11,10]]},"published-print":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.1007\/s40620-021-01160-5","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2021,11,10]]},"assertion":[{"value":"18 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"K.T.B. is a consultant to Kadmon, Otsuka, and Sanofi and submitted a provisional patent application. K.K., A.Y., M.K., S.H., T.Y., J.T.B, and S.N. have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Fujita Health University Animal Care and Use Committee and followed the ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}