{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:21:24Z","timestamp":1789676484545,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s40620-021-01226-4","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T06:04:44Z","timestamp":1641276284000},"page":"1243-1249","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Management of acute kidney injury in frail patients with biopsy-proven cast nephropathy: a combined approach with chemotherapy plus Supra-hemodiafiltration with post-adsorption endogenous reinfusion"],"prefix":"10.1093","volume":"35","author":[{"given":"Stefano","family":"Murgia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Quattrocchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Forneris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pozzato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Fenoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"De Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Del Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Benedetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Roccatello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"1226_CR1","doi-asserted-by":"publisher","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","volume":"15","author":"SV Rajkumar","year":"2014","unstructured":"Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S et al (2014) International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 15:e538\u2013e548","journal-title":"Lancet Oncol"},{"key":"1226_CR2","doi-asserted-by":"publisher","first-page":"4976","DOI":"10.1200\/JCO.2010.30.8791","volume":"28","author":"MA Dimopoulos","year":"2010","unstructured":"Dimopoulos MA, Terpos E (2010) Chanan-Khan A et al Renal impairment in patients with multiple myeloma: a consensus statement on behalf of the International Myeloma Working Group. J Clin Oncol 28:4976\u20134984","journal-title":"J Clin Oncol"},{"issue":"1","key":"1226_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nrneph.2011.168","volume":"8","author":"CA Hutchison","year":"2011","unstructured":"Hutchison CA, Batuman V, Behrens J et al (2011) The pathogenesis and diagnosis of acute kidney injury in multiple myeloma. Nat Rev Nephrol 8(1):43\u201345","journal-title":"Nat Rev Nephrol"},{"key":"1226_CR4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4065\/78.1.21","volume":"78","author":"RA Kyle","year":"2003","unstructured":"Kyle RA et al (2003) Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 78:21\u201333","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"1226_CR5","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3816\/CLM.2009.n.059","volume":"9","author":"MA Dimopoulos","year":"2009","unstructured":"Dimopoulos MA, Roussou M, Gavriatopoulou M et al (2009) Reversibility of renal impairment in patients with multiple myeloma treated with bortezomib based regimens. Clin Lymphoma Myeloma 9(4):302\u2013306","journal-title":"Clin Lymphoma Myeloma"},{"issue":"13","key":"1226_CR6","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1200\/JCO.2015.65.0044","volume":"34","author":"MA Dimopoulos","year":"2016","unstructured":"Dimopoulos MA, Sonneveld P, Leung N, Merlini G, Ludwig H, Kastritis E, Goldschmidt H, Joshua D, Orlowski RZ, Powles R, Vesole DH, Garderet L, Einsele H, Palumbo A, Cavo M, Richardson PG, Moreau P, San Miguel J, Rajkumar SV, Durie BG, Terpos E (2016) International Myeloma Working Group recommendations for the diagnosis and management of myeloma-related renal impairment. J Clin Oncol 34(13):1544\u20131557","journal-title":"J Clin Oncol"},{"issue":"2","key":"1226_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s40620-018-0492-4","volume":"32","author":"IJ Sathick","year":"2019","unstructured":"Sathick IJ, Drosou ME, Leung N (2019) Myeloma light chain cast nephropathy, a review. J Nephrol 32(2):189\u2013198","journal-title":"J Nephrol"},{"key":"1226_CR8","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1159\/000107239","volume":"150","author":"ML Wratten","year":"2007","unstructured":"Wratten ML, Ghezzi PM (2007) Hemodiafiltration with endogenous reinfusion. Contrib Nephrol 150:94\u2013102","journal-title":"Contrib Nephrol"},{"key":"1226_CR9","unstructured":"R Core Team (2020) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna. https:\/\/www.r-project.org\/index.html. Accessed 25 Aug 2021"},{"issue":"3","key":"1226_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1600-0609.2009.01385.x","volume":"84","author":"F Morabito","year":"2010","unstructured":"Morabito F, Gentile M, Ciolli S, Petrucci MT, Galimberti S, Mele G, Casulli AF, Mannina D, Piro E, Pinotti G, Palmieri S, Catalano L, Callea V, Offidani M, Musto P, Bringhen S, Baldini L, Tosi P, Di Raimondo F, Boccadoro M, Palumbo A, Cavo M (2010) Safety and efficacy of bortezomib-based regimens for multiple myeloma patients with renal impairment: a retrospective study of Italian Myeloma Network GIMEMA. Eur J Haematol 84(3):223\u2013228","journal-title":"Eur J Haematol"},{"issue":"10068","key":"1226_CR11","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0140-6736(16)31594-X","volume":"389","author":"BGM Durie","year":"2017","unstructured":"Durie BGM, Hoering A, Abidi MH, Rajkumar SV, Epstein J, Kahanic SP, Thakuri M, Reu F, Reynolds CM, Sexton R, Orlowski RZ, Barlogie B, Dispenzieri A (2017) Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. Lancet 389(10068):519\u2013527","journal-title":"Lancet"},{"key":"1226_CR12","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/leu.2012.182","volume":"27","author":"MA Dimopoulos","year":"2013","unstructured":"Dimopoulos MA, Roussou M, Gkotzamanidou M et al (2013) The role of novel agents on the reversibility of renal impairment in newly diagnosed symptomatic patients with multiple myeloma. Leukemia 27:423\u2013429","journal-title":"Leukemia"},{"key":"1226_CR13","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.2215\/CJN.02290508","volume":"3","author":"CA Hutchison","year":"2008","unstructured":"Hutchison CA, Harding S, Hewins P et al (2008) Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease. Clin J Am Soc Nephrol 3:1684\u20131690","journal-title":"Clin J Am Soc Nephrol"},{"key":"1226_CR14","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/ki.1988.127","volume":"33","author":"P Zucchelli","year":"1988","unstructured":"Zucchelli P, Pasquali S, Cagnoli L et al (1988) Controlled plasma exchange trial in acute renal failure due to multiple myeloma. Kidney Int 33:1175\u20131180","journal-title":"Kidney Int"},{"key":"1226_CR15","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1001\/archinte.1990.00390160111022","volume":"150","author":"WJ Johnson","year":"1990","unstructured":"Johnson WJ, Kyle RA, Pineda AA et al (1990) Treatment of renal failure associated with multiple myeloma plasmapheresis, hemodialysis, and chemotherapy. Arch Intern Med 150:863\u2013869","journal-title":"Arch Intern Med"},{"key":"1226_CR16","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/0003-4819-143-11-200512060-00005","volume":"143","author":"WF Clark","year":"2005","unstructured":"Clark WF, Stewart AK, Rock GA et al (2005) Plasma exchange when myeloma presents as acute renal failure: a randomized, controlled trial. Ann Intern Med 143:777\u2013784","journal-title":"Ann Intern Med"},{"key":"1226_CR17","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1681\/ASN.2006080821","volume":"18","author":"CA Hutchison","year":"2007","unstructured":"Hutchison CA, Cockwell P, Reid S et al (2007) Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma: in vitro and in vivo studies. J Am Soc Nephrol 18:886\u2013895","journal-title":"J Am Soc Nephrol"},{"key":"1226_CR18","doi-asserted-by":"crossref","unstructured":"Bridoux F, Carron PL, Pegourie B, Alamartine E, Augeul-Meunier K, Karras A et al, for the MYRE Study Group (2017) Effect of high-cut-off hemodialysis vs conventional hemodialysis on hemodialysis independence among patients with myeloma cast nephropathy. JAMA 318(21):2099\u20132110","DOI":"10.1001\/jama.2017.17924"},{"issue":"4","key":"1226_CR19","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1016\/S2352-3026(19)30014-6","volume":"6","author":"CA Hutchison","year":"2019","unstructured":"Hutchison CA, Cockwell P, Moroz V, Bradwell AR, Fifer L, Gillmore JD et al (2019) High cutoff versus high-flux haemodialysis for myeloma cast nephropathy in patients receiving bortezomib-based chemotherapy (EuLITE): a phase 2 randomised controlled trial. Lancet Haematol 6(4):e217\u2013e228","journal-title":"Lancet Haematol"},{"issue":"2","key":"1226_CR20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5301\/jo-n.5000018","volume":"1","author":"K Finkel","year":"2017","unstructured":"Finkel K, Fabbrini P (2017) High cut-off haemodialysis for myeloma cast nephropathy\u2014do we finally have an answer? J Onco-Nephrol 1(2):67\u201370","journal-title":"J Onco-Nephrol"},{"key":"1226_CR21","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1111\/j.1525-1594.2008.00653.x","volume":"32","author":"CA Hutchison","year":"2008","unstructured":"Hutchison CA, Harding S, Mead G, Goehl H, Storr H, Bradwell AR, Cockwell P (2008) Serum free light chain removal by high cut-off hemodialysis: optimising removal and supportive care. Artif Organs 32:910\u2013917","journal-title":"Artif Organs"},{"issue":"6","key":"1226_CR22","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s40620-016-0347-9","volume":"29","author":"P Fabbrini","year":"2016","unstructured":"Fabbrini P, Finkel K, Gallieni M, Capasso G, Cavo M, Santoro A, Pasquali S (2016) Light chains removal by extracorporeal techniques in acute kidney injury due to multiple myeloma: a position statement of the Onconephrology Work Group of the Italian Society of Nephrology. J Nephrol 29(6):735\u2013746","journal-title":"J Nephrol"},{"key":"1226_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s40620-014-0130-8","volume":"28","author":"S Pasquali","year":"2015","unstructured":"Pasquali S, Iannuzzella F, Corradini M, Mattei S, Bovino A, Stefani A et al (2015) A novel option for reducing free light chains in myeloma kidney: suprahemodiafiltration with endogenous reinfusion (HFR). J Nephrol 28:251\u2013254","journal-title":"J Nephrol"},{"key":"1226_CR24","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1159\/000492408","volume":"43","author":"P Men\u00e8","year":"2018","unstructured":"Men\u00e8 P, Giammarioli E, Fofi C, Antolino G, La Verde G, Tafuri A et al (2018) Serum free light chains removal by HFR hemodiafiltration in patients with multiple myeloma and acute kidney injury: a case series. Kidney Blood Press Res 43:1263\u20131272","journal-title":"Kidney Blood Press Res"},{"key":"1226_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1159\/000316684","volume":"30","author":"A Testa","year":"2010","unstructured":"Testa A, Dejoie T, Lecarr D, Wratten M, Sereni L, Renaux JL (2010) Reduction of Free immunoglobulin light chains using adsorption properties of hemodiafiltration with endogenous reinfusion. Blood Purif 30:34\u201336","journal-title":"Blood Purif"},{"key":"1226_CR26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s12882-020-01885-8","volume":"21","author":"M Pend\u00f3n-Ruiz de Mier","year":"2020","unstructured":"Pend\u00f3n-Ruiz de Mier M, Ojeda R, \u00c1lvarez-Lara MA et al (2020) Hemodiafiltration with ultrafiltrate regeneration reduces free light chains without albumin loss in multiple myeloma patients. BMC Nephrol 21:227","journal-title":"BMC Nephrol"},{"key":"1226_CR27","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/ki.2008.108","volume":"73","author":"N Leung","year":"2008","unstructured":"Leung N, Gertz MA, Zeldenrust SR et al (2008) Improvement of cast nephropathy with plasma exchange depends on the diagnosis and on reduction of serum free light chains. Kidney Int 73:1282\u20131288","journal-title":"Kidney Int"},{"issue":"1","key":"1226_CR28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/ndt\/gfv283","volume":"31","author":"L Ecoti\u00e8re","year":"2016","unstructured":"Ecoti\u00e8re L, Thierry A, Debiais-Delpech C, Chevret S, Javaugue V, Desport E, Belmouaz S, Quellard N, Kaaki S, Goujon JM, Fermand JP, Touchard G, Bridoux F (2016) Prognostic value of kidney biopsy in myeloma cast nephropathy: a retrospective study of 70 patients. Nephrol Dial Transplant 31(1):64\u201372","journal-title":"Nephrol Dial Transplant"},{"issue":"21","key":"1226_CR29","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1182\/blood.2019003807","volume":"135","author":"V Royal","year":"2020","unstructured":"Royal V, Leung N, Troyanov S, Nasr SH, \u00c9coti\u00e8re L, LeBlanc R, Adam BA, Angioi A, Alexander MP, Asunis AM, Barreca A, Bianco P, Cohen C, Drosou ME, Fatima H, Fenoglio R, Gougeon F, Goujon JM, Herrera GA, Knebelmann B, Lepori N, Maletta F, Manso R, Motwani SS, Pani A, Rabant M, Rennke HG, Rocatello D, Rosenblum F, Sanders PW, Santos A, Soto K, Sis B, Touchard G, Venner CP, Bridoux F (2020) Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: a multicenter retrospective study. Blood 135(21):1833\u20131846","journal-title":"Blood"},{"key":"1226_CR30","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/ndt\/gfp488","volume":"25","author":"RJ Haynes","year":"2010","unstructured":"Haynes RJ, Read S, Collins GP et al (2010) Presentation and survival of patients with severe acute kidney injury and multiple myeloma: a 20-year experience from a single centre. Nephrol Dial Transplant 25:419\u2013426","journal-title":"Nephrol Dial Transplant"},{"issue":"10","key":"1226_CR31","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.3390\/jcm9103232","volume":"9","author":"D Roccatello","year":"2020","unstructured":"Roccatello D, Fenoglio R, Naretto C, Baldovino S, Sciascia S, Ferro M, Rossi D (2020) Daratumumab monotherapy in severe patients with AL amyloidosis and biopsy-proven renal involvement: a real life experience. J Clin Med 9(10):3232","journal-title":"J Clin Med"},{"issue":"11","key":"1226_CR32","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.3390\/ijms21114129","volume":"21","author":"D Roccatello","year":"2020","unstructured":"Roccatello D, Fenoglio R, Sciascia S, Naretto C, Rossi D, Ferro M, Barreca A, Malavasi F, Baldovino S (2020) CD38 and anti-CD38 monoclonal antibodies in AL amyloidosis: targeting plasma cells and beyond. Int J Mol Sci 21(11):4129","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-021-01226-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-021-01226-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-021-01226-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:55:15Z","timestamp":1777564515000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/35\/4\/1243\/8325863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["1226"],"URL":"https:\/\/doi.org\/10.1007\/s40620-021-01226-4","relation":{},"ISSN":["1724-6059"],"issn-type":[{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]},"assertion":[{"value":"25 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted retrospectively from data obtained for clinical purposes and thus it did not need ethical approval.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}