{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:53:21Z","timestamp":1790488401024,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["FIS\/IMSS\/PROT\/PRIO\/14\/036"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/PRIO\/14\/036"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s40620-022-01299-9","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T05:04:46Z","timestamp":1648616686000},"page":"1699-1708","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical usefulness of angiogenic factors in women with chronic kidney disease and suspected superimposed preeclampsia"],"prefix":"10.1093","volume":"35","author":[{"given":"Carlos Jos\u00e9","family":"Molina-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Graciela","family":"Nolasco-Lea\u00f1os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyes Ismael","family":"Carrillo-Ju\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Lea\u00f1os-Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"1299_CR1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","volume":"382","author":"V Jha","year":"2013","unstructured":"Jha V, Garcia-Garcia G, Iseki K et al (2013) Chronic kidney disease: global dimension and perspectives. Lancet 382:260\u2013272","journal-title":"Lancet"},{"key":"1299_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/nrneph.2017.187","volume":"14","author":"KS Wiles","year":"2018","unstructured":"Wiles KS, Nelson-Piercy C, Bramham K (2018) Reproductive health and pregnancy in women with chronic kidney disease. Nat Rev Nephrol 14:165\u2013184","journal-title":"Nat Rev Nephrol"},{"key":"1299_CR3","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1093\/ndt\/gfp320","volume":"24","author":"J Munkhaugen","year":"2009","unstructured":"Munkhaugen J, Lydersen S, Romundstad PR, Wider\u00f8e TE, Vikse BE, Hallan S (2009) Kidney function and future risk for adverse pregnancy outcomes: a population-based study from HUNT II, Norway. Nephrol Dial Transpl 24:3744\u20133750","journal-title":"Nephrol Dial Transpl"},{"key":"1299_CR4","first-page":"2015","volume":"127083","author":"A Rolfo","year":"2015","unstructured":"Rolfo A, Attini R, Tavassoli E et al (2015) Is it possible to differentiate chronic kidney disease and preeclampsia by means of new and old biomarkers? A prospective study. Dis Markers 127083:2015","journal-title":"Dis Markers"},{"key":"1299_CR5","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.2215\/CJN.09250914","volume":"10","author":"J-J Zhang","year":"2015","unstructured":"Zhang J-J, Ma X-X, Hao L, Liu L-J, Lv J-C, Zhang H (2015) A Systematic review and meta-analysis of outcomes of pregnancy in CKD and CKD outcomes in pregnancy. Clin J Am Soc Nephrol 10:1964\u20131978","journal-title":"Clin J Am Soc Nephrol"},{"key":"1299_CR6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s40620-018-0536-9","volume":"32","author":"A Lea\u00f1os-Miranda","year":"2019","unstructured":"Lea\u00f1os-Miranda A, Campos-Galicia I, Ram\u00edrez-Valenzuela KL, Berumen-Lechuga MG, Isordia-Salas I, Molina-P\u00e9rez CJ (2019) Urinary IgM excretion: a reliable marker for adverse pregnancy outcomes in women with chronic kidney disease. J Nephrol 32:241\u2013251","journal-title":"J Nephrol"},{"key":"1299_CR7","doi-asserted-by":"publisher","first-page":"844","DOI":"10.2215\/CJN.07911109","volume":"5","author":"GB Piccoli","year":"2010","unstructured":"Piccoli GB, Attini R, Vassario E et al (2010) Pregnancy and chronic kidney disease: a challenge in all CKD stages. Clin J Am Soc Nephrol 5:844\u2013855","journal-title":"Clin J Am Soc Nephrol"},{"key":"1299_CR8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1136\/bmj.39406.652986.BE","volume":"336","author":"D Williams","year":"2008","unstructured":"Williams D, Davison J (2008) Chronic kidney disease in pregnancy. BMJ 336:211\u2013215","journal-title":"BMJ"},{"key":"1299_CR9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jaut.2017.01.008","volume":"79","author":"GB Piccoli","year":"2017","unstructured":"Piccoli GB, Attini R, Cabiddu G et al (2017) Maternal-foetal outcomes in pregnant women with glomerulonephritides. Are all glomerulonephritides alike in pregnancy? J Autoimmun 79:91\u201398","journal-title":"J Autoimmun"},{"key":"1299_CR10","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1093\/ndt\/gfs573","volume":"28","author":"GB Piccoli","year":"2013","unstructured":"Piccoli GB, Gaglioti P, Attini R et al (2013) Pre-eclampsia or chronic kidney disease? The flow hypothesis. Nephrol Dial Transpl 28:1199\u20131206","journal-title":"Nephrol Dial Transpl"},{"key":"1299_CR11","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1172\/JCI17189","volume":"111","author":"SE Maynard","year":"2003","unstructured":"Maynard SE, Min JY, Merchan J et al (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111:649\u2013658","journal-title":"J Clin Invest"},{"key":"1299_CR12","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/nm1429","volume":"12","author":"S Venkatesha","year":"2006","unstructured":"Venkatesha S, Toporsian M, Lam C et al (2006) Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12:642\u2013649","journal-title":"Nat Med"},{"key":"1299_CR13","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1056\/NEJMoa031884","volume":"350","author":"RJ Levine","year":"2004","unstructured":"Levine RJ, Maynard SE, Qian C et al (2004) Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350:672\u2013683","journal-title":"N Engl J Med"},{"key":"1299_CR14","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1056\/NEJMoa055352","volume":"355","author":"RJ Levine","year":"2006","unstructured":"Levine RJ, Lam C, Qian C et al (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355:992\u20131005","journal-title":"N Engl J Med"},{"key":"1299_CR15","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1097\/HJH.0b013e328357c0c9","volume":"30","author":"A Lea\u00f1os-Miranda","year":"2012","unstructured":"Lea\u00f1os-Miranda A, Campos-Galicia I, Isordia-Salas I et al (2012) Changes in circulating concentrations of soluble fms-like tyrosine kinase-1 and placental growth factor measured by automated electrochemiluminescence immunoassays methods are predictors of preeclampsia. J Hypertens 30:2173\u20132181","journal-title":"J Hypertens"},{"key":"1299_CR16","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1161\/CIRCULATIONAHA.111.054361","volume":"125","author":"S Rana","year":"2012","unstructured":"Rana S, Powe CE, Salahuddin S et al (2012) Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia. Circulation 125:911\u2013919","journal-title":"Circulation"},{"key":"1299_CR17","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1161\/HYPERTENSIONAHA.111.00754","volume":"61","author":"A Lea\u00f1os-Miranda","year":"2013","unstructured":"Lea\u00f1os-Miranda A, Campos-Galicia I, Ram\u00edrez-Valenzuela KL, Chinolla-Arellano ZL, Isordia-Salas I (2013) Circulating angiogenic factors and urinary prolactin as predictors of adverse outcomes in women with preeclampsia. Hypertension 61:1118\u20131125","journal-title":"Hypertension"},{"key":"1299_CR18","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.kint.2015.10.012","volume":"89","author":"K Bramham","year":"2016","unstructured":"Bramham K, Seed PT, Lightstone L et al (2016) Diagnostic and predictive biomarkers for pre-eclampsia in patients with established hypertension and chronic kidney disease. Kidney Int 89:874\u2013885","journal-title":"Kidney Int"},{"key":"1299_CR19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1159\/000339935","volume":"74","author":"H Masuyama","year":"2012","unstructured":"Masuyama H, Nobumoto E, Okimoto N, Inoue S, Segawa T, Hiramatsu Y (2012) Superimposed preeclampsia in women with chronic kidney disease. Gynecol Obstet Invest 74:274\u2013281","journal-title":"Gynecol Obstet Invest"},{"key":"1299_CR20","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.ajog.2005.08.034","volume":"194","author":"H Masuyama","year":"2006","unstructured":"Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y (2006) Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis. Am J Obstet Gynecol 194:551\u2013556","journal-title":"Am J Obstet Gynecol"},{"key":"1299_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/kisup.2012.73","volume":"3","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2013","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2013) KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3:1\u2013150","journal-title":"Kidney Int Suppl"},{"key":"1299_CR22","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604\u2013612","journal-title":"Ann Intern Med"},{"key":"1299_CR23","unstructured":"Clinical practice guideline for acute kidney injury. Kidney Disease: Improving Global Outcomes (vol 2), 2012. https:\/\/kdigo.org\/wp-content\/uploads\/2016\/10\/KDIGO-2012-AKI-Guideline-English.pdf. Accessed Mar 2012"},{"key":"1299_CR24","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","volume":"122","author":"American College of Obstericians, Gynecologists","year":"2013","unstructured":"American College of Obstericians, Gynecologists (2013) Task force on hypertension in pregnancy. Obstet Gynecol 122:1122\u20131131","journal-title":"Obstet Gynecol"},{"key":"1299_CR25","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/uog.5315","volume":"32","author":"O G\u00f3mez","year":"2008","unstructured":"G\u00f3mez O, Figueras F, Fern\u00e1ndez S et al (2008) Reference ranges for uterine artery mean pulsatility index at 11\u201341 weeks of gestation. Ultrasound Obstet Gynecol 32:128\u2013132","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1299_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1414838","volume":"374","author":"H Zeisler","year":"2016","unstructured":"Zeisler H, Llurba E, Chantraine F et al (2016) Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia. N Engl J Med 374:13\u201322","journal-title":"N Engl J Med"},{"key":"1299_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3109\/10641955.2013.784788","volume":"32","author":"S Rana","year":"2013","unstructured":"Rana S, Schnettler WT, Powe C et al (2013) Clinical characterization and outcomes of preeclampsia with normal angiogenic profile. Hypertens Preg 32:189\u2013201","journal-title":"Hypertens Preg"},{"key":"1299_CR28","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1161\/HYPERTENSIONAHA.120.15552","volume":"76","author":"A Lea\u00f1os-Miranda","year":"2020","unstructured":"Lea\u00f1os-Miranda A, Nolasco-Lea\u00f1os AG, Carrillo-Ju\u00e1rez RI et al (2020) Usefulness of the sFlt-1\/PlGF (Soluble fms-Like Tyrosine Kinase-1\/Placental Growth Factor) ratio in diagnosis or misdiagnosis in women with clinical diagnosis of preeclampsia. Hypertension 76:892\u2013900","journal-title":"Hypertension"},{"key":"1299_CR29","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1681\/ASN.2014050459","volume":"26","author":"GB Piccoli","year":"2015","unstructured":"Piccoli GB, Cabiddu G, Attini R et al (2015) Risk of adverse pregnancy outcomes in women with CKD. J Am Soc Nephrol 26:2011\u20132022","journal-title":"J Am Soc Nephrol"},{"key":"1299_CR30","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.3390\/ijms20174246","volume":"20","author":"T Tomimatsu","year":"2019","unstructured":"Tomimatsu T, Mimura K, Matsuzaki S, Endo M, Kumasawa K, Kimura T (2019) Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors. Int J Mol Sci 20:4246","journal-title":"Int J Mol Sci"},{"key":"1299_CR31","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1161\/HYPERTENSIONAHA.119.12760","volume":"74","author":"X Bian","year":"2019","unstructured":"Bian X, Biswas A, Huang X et al (2019) Short-term prediction of adverse outcomes using the sFlt-1 (soluble fms-like tyrosine kinase 1)\/PlGF (placental growth factor) ratio in Asian women with suspected preeclampsia. Hypertension 74:164\u2013172","journal-title":"Hypertension"},{"key":"1299_CR32","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/uog.18894","volume":"52","author":"I Herraiz","year":"2018","unstructured":"Herraiz I, Quezada MS, Rodriguez-Calvo J, G\u00f3mez-Montes E, Villala\u00edn C, Galindo A (2018) Longitudinal change of sFlt-1\/PlGF ratio in singleton pregnancy with early-onset fetal growth restriction. Ultrasound Obstet Gynecol 52:631\u2013638","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"10","key":"1299_CR33","doi-asserted-by":"publisher","first-page":"e48259","DOI":"10.1371\/journal.pone.0048259","volume":"7","author":"S Rana","year":"2012","unstructured":"Rana S, Cerdeira AS, Wenger J et al (2012) Plasma concentrations of soluble endoglin versus standard evaluation in patients with suspected preeclampsia. PLoS ONE 7(10):e48259","journal-title":"PLoS ONE"},{"key":"1299_CR34","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1161\/HYPERTENSIONAHA.119.13348","volume":"74","author":"A Lea\u00f1os-Miranda","year":"2019","unstructured":"Lea\u00f1os-Miranda A, Navarro-Romero CS, Sillas-Pardo LJ, Ram\u00edrez-Valenzuela KL, Isordia-Salas I, Jim\u00e9nez-Trejo LM (2019) Soluble endoglin as a marker for preeclampsia, its severity, and the occurrence of adverse outcomes. Hypertension 74:991\u2013997","journal-title":"Hypertension"},{"key":"1299_CR35","doi-asserted-by":"publisher","first-page":"161.e1","DOI":"10.1016\/j.ajog.2009.09.016","volume":"202","author":"S Verlohren","year":"2010","unstructured":"Verlohren S, Galindo A, Schlembach D et al (2010) An automated method for the determination of the sFlt-1\/PIGF ratio in the assessment of preeclampsia. Am J Obstet Gynecol 202:161.e1-161.e11","journal-title":"Am J Obstet Gynecol"},{"key":"1299_CR36","doi-asserted-by":"publisher","first-page":"e6005","DOI":"10.1097\/MD.0000000000006005","volume":"96","author":"A Lea\u00f1os-Miranda","year":"2017","unstructured":"Lea\u00f1os-Miranda A, M\u00e9ndez-Aguilar F, Ram\u00edrez-Valenzuela KL et al (2017) Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes. Medicine (Baltimore) 96:e6005","journal-title":"Medicine (Baltimore)"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-022-01299-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-022-01299-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-022-01299-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:54:36Z","timestamp":1777564476000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/35\/6\/1699\/8325670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,30]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1299"],"URL":"https:\/\/doi.org\/10.1007\/s40620-022-01299-9","relation":{},"ISSN":["1724-6059"],"issn-type":[{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,30]]},"assertion":[{"value":"2 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in human subjects were in compliance with the ethical standards of the 1964 Helsinki declaration and its later amendments. The project was approved by our National Ethics and Research Committees.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participating individuals included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}