{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:50:27Z","timestamp":1788825027426,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Science and Technology Major Projects for major new drugs innovation and development","award":["2017ZX09304028"],"award-info":[{"award-number":["2017ZX09304028"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2019-I2M-5-046"],"award-info":[{"award-number":["2019-I2M-5-046"]}]},{"name":"National Science and Technology Major Projects for major new drugs innovation and development","award":["2017ZX09304028"],"award-info":[{"award-number":["2017ZX09304028"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2019-I2M-5-046"],"award-info":[{"award-number":["2019-I2M-5-046"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal sarcoidosis is a rare cause of tubulointerstitial nephritits\u00a0(TIN). The clinical and pathological characteristics, as well as outcomes, of renal sarcoidosis remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center study retrospectively analyzed 18 patients affected by\u00a0sarcoidosis with tubulointerstitial nephritis (TIN) and 53 patients with tubulointerstitial nephritis\u00a0\u00a0not related to sarcoidosis.\u00a0Patients\u00a0were further stratified into the granulomatous (12 sarcoidosis and 6 non-sarcoidosis) and non-granulomatous (6 sarcoidosis and 47 non-sarcoidosis) TIN groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Half of the patients with renal sarcoidosis had signs of\u00a0acute kidney\u00a0injury at kidney\u00a0biopsy, 94% of whom presented with extra-renal involvement. The prevalence of hypercalcemia, hypercalciuria, and elevated serum angiotensin-converting enzyme levels was 27.6%, 33.3%, and 31.3%, respectively. Renal sarcoidosis patients with eGFR\u2009&amp;lt;\u200930\u00a0mL\/min\/1.73 m2 scored higher for total chronic tubulointerstitial injury (p\u2009=\u20090.044) and glomerular sclerosis (p\u2009=\u20090.027). Compared to non-sarcoidosis\u00a0patients, higher urinary calcium levels (for patients with GFR \u2265 40\u00a0mL\/min\/1.73 m2, p\u2009=\u20090.034), lower scores of acute tubular injury (p\u2009=\u20090.008), and more prominent glomerular sclerosis were observed in renal sarcoidosis. Similar characteristics of chronicity and hypercalciuria were also identified in granulomatous interstitial nephritis; however, interstitial inflammation was obvious (p\u2009=\u20090.001). Patients with renal sarcoidosis were initially treated with corticosteroids. Five patients receiving immunosuppressive agents showed better long-term renal recovery. High 24-h urine calcium (adjusted by weight) was identified as a factor associated with long-term remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Renal sarcoidosis is a systemic disease of insidious onset and chronic progression, sharing similar features of chronicity and hypercalciuria with granulomatous interstitial nephritis\u00a0of other cause. Hypercalciuria may predict a better response to\u00a0immunosuppressive therapy, presumably\u00a0indicating active interstitial inflammation; thus, strengthened immunosuppression might be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01360-7","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T10:34:04Z","timestamp":1655116444000},"page":"69-82","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hypercalciuria may predict better response to immunosuppressive therapy\u00a0in renal sarcoidosis: a case series"],"prefix":"10.1093","volume":"36","author":[{"given":"Tao","family":"Zhao","sequence":"first","affiliation":[{"name":"Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, No.8 Xishiku Street, Xicheng District, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, No.8 Xishiku Street, Xicheng District, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, No.8 Xishiku Street, Xicheng District, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, No.8 Xishiku Street, Xicheng District, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-8146","authenticated-orcid":false,"given":"Tao","family":"Su","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, No.8 Xishiku Street, Xicheng District, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"issue":"21","key":"2026012307480528200_CR1","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1056\/NEJMra071714","article-title":"Sarcoidosis","volume":"357","author":"Iannuzzi","year":"2007","journal-title":"N Engl J Med"},{"issue":"1","key":"2026012307480528200_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s12890-020-01191-x","article-title":"Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts","volume":"20","author":"Te","year":"2020","journal-title":"BMC Pulm Med"},{"issue":"3","key":"2026012307480528200_CR3","doi-asserted-by":"publisher","first-page":"252","DOI":"10.36141\/svdld.v35i3.6655","article-title":"Clinical characteristics of biopsy-proven renal sarcoidosis in Japan","volume":"35","author":"Kamata","year":"2018","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"issue":"2","key":"2026012307480528200_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00408-017-0076-4","article-title":"The burden of comorbidity and complexity in sarcoidosis: impact of associated chronic diseases","volume":"196","author":"Brito-Zer\u00f3n","year":"2018","journal-title":"Lung"},{"issue":"5","key":"2026012307480528200_CR5","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/MCP.0000000000000504","article-title":"Renal sarcoidosis: approach to diagnosis and management","volume":"24","author":"Bergner","year":"2018","journal-title":"Curr Opin Pulm Med"},{"issue":"8","key":"2026012307480528200_CR6","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1164\/rccm.202002-0251ST","article-title":"Diagnosis and detection of sarcoidosis. 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