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The biological function of podocytes is primarily based on a complex ramified structure that requires sufficient nutrients and a large supply of energy in support of their unique structure and function in the glomeruli. Of note, the dysregulation of nutrient signaling and energy metabolic pathways in podocytes has been associated with a range of kidney diseases i.e., diabetic nephropathy. Therefore, nutrient-related and energy metabolic signaling pathways are critical to maintaining podocyte homeostasis and the pathogenesis of podocyte injury. Recently, a growing body of evidence has indicated that nutrient starvation induces autophagy, which suggests crosstalk between nutritional signaling with the modulation of autophagy for podocytes to adapt to nutrient deprivation. In this review, the current knowledge and advancement in the understanding of nutrient sensing, signaling, and autophagy in the podocyte biology, injury, and pathogenesis of kidney diseases is summarized. Based on the existing findings, the implications and perspective to target these signaling pathways and autophagy in podocytes during the development of novel preventive and therapeutic strategies in patients with podocyte injury-associated kidney diseases are discussed.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01365-2","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T07:02:49Z","timestamp":1655276569000},"page":"17-29","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nutrient sensing, signaling transduction, and autophagy in podocyte injury: implications for kidney disease"],"prefix":"10.1093","volume":"36","author":[{"given":"Dongqing","family":"Zha","sequence":"first","affiliation":[{"name":"Division of Nephrology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, 430070, Wuhan, Hubei, China 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5769-0709","authenticated-orcid":false,"given":"Xiaoyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, 430070, Wuhan, Hubei, China 1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"2026012307480733600_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.573557","article-title":"Glomerular endothelial cells as instigators of glomerular sclerotic diseases","volume":"11","author":"Sol","year":"2020","journal-title":"Front Pharmacol"},{"key":"2026012307480733600_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.659013","article-title":"Glomerular endothelial cell crosstalk with podocytes in diabetic kidney 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