{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:53:20Z","timestamp":1776135200716,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Indications for kidney biopsy in adult IgA vasculitis\u00a0(IgAV) remain debated and there are very few studies on this subject. The aim of this study was to establish a correlation between renal\u00a0histological and clinical-laboratory data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter study was conducted using three databases from French hospitals, gathered between 1977 and 2020. The study included 294 adult patients with IgAV who had undergone kidney biopsy assessed according to the\u00a0prognostic \u201cPillebout classification\u201d. Different statistical models were used to test the correlations between histological and clinical-laboratory data: Cochran Armitage, ANOVA, Kruskal\u2013Wallis and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patients were primarily men (64%), with a mean age of 52\u00a0years. The main organs and tissues involved were: dermatological 100%, digestive 48% and rheumatological 61%. All had features of\u00a0kidney involvement.\u00a0The median serum creatinine was 96\u00a0\u00b5mol\/L\u00a0serum albumin 35 g\/L, and\u00a0C-reactive protein\u00a028 mg\/L. Of the patients, 86% (n\u2009=\u2009254) had hematuria and median proteinuria was 1.8\u00a0g\/day. The only statistically significant correlation between the pathological stages and the clinical-laboratory data was the presence of hematuria (p\u2009=\u20090.03, 66% class I to 92% class IV). In multivariate analysis, only albuminemia was associated with extracapillary proliferation (p\u2009=\u20090.02; OR 0.94) and only age was associated with stages 3\u20134 (p\u2009=\u20090.03; OR 1.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that there is no strict baseline correlation between renal pathology and clinical-laboratory data. Given the current knowledge, it seems relevant to recommend a kidney biopsy in the presence of significant and persistent proteinuria or unexplained kidney function decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01389-8","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T05:03:11Z","timestamp":1660366991000},"page":"485-494","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Towards better indications for kidney biopsy in adult IgA\u00a0vasculitis: a clinical-laboratory and pathology correlation study"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-7894","authenticated-orcid":false,"given":"Valentin","family":"Maisons","sequence":"first","affiliation":[{"name":"University of Tours, Tours, France 1"},{"name":"Department of Nephrology, Hopital Bretonneau, CHRU de Tours, Tours, France 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Halimi","sequence":"additional","affiliation":[{"name":"University of Tours, Tours, France 1"},{"name":"Department of Nephrology, Hopital Bretonneau, CHRU de Tours, Tours, France 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Barbet","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hopital Bretonneau, CHRU de Tours, Tours, France 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9vangeline","family":"Pillebout","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hopital Saint-Louis, APHP, Paris, France 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhour","family":"El Ouafi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, CHU Limoges, Limoges, France 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Thervet","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hopital Europ\u00e9en Georges Pompidou, APHP, Paris, France 5"},{"name":"University Paris Descartes, Paris, France 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Terrier","sequence":"additional","affiliation":[{"name":"University Paris Descartes, Paris, France 6"},{"name":"Department of Internal Medicine, H\u00f4pital Cochin, Paris, France 7"},{"name":"National Referral Center for Systemic and Autoimmune Diseases, H\u00f4pital Cochin, Paris, France 8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanis","family":"Ramdani","sequence":"additional","affiliation":[{"name":"University of Tours, Tours, France 1"},{"name":"Department of Internal Medicine and Clinical Immunology, CHRU Tours, University of Tours, Tours, France 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April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The content of this article confirmed to ethical guidelines of the Helsinki declaration (as revised in Tokyo 2004). Both Pillebout and IGAVAS databases had already been approved by the institutional review boards. Procedures for data collection and management of patients recruited in the nephrology department of the Tours university hospital were approved by the \u201cCommission Nationale de l'Informatique et des Libert\u00e9s\u201d (CNIL), the independent National Ethics Committee protecting human rights in France (MR-004 registration number F20210304102053).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}