{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:27:51Z","timestamp":1769174871524,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Following the widespread use of anti SARS-CoV-2 vaccines, there have been reports of thrombocytopenia developing after the administration of\u00a0different types of vaccine. We report a case of a 63-year-old male who developed neurological symptoms after receiving the second dose of the bnt162b2 vaccine. Blood tests performed upon admission to the Emergency Department revealed severe thrombocytopenia and microangiopathic hemolytic anemia. ADAMTS13 activity was\u00a0undetectable and antibody titer was high. Due to the rapid neurological deterioration, steroid therapy with prednisone was started at an initial dose of 1\u00a0mg\/kg\/day. Rituximab therapy was started to prevent the formation of new antibodies. Given the slow response to this therapy, we added Caplacizumab, (a\u00a0monoclonal antibody anti-Von Willebrand factor) in order to inhibit platelet hyperaggregation, combined with standard plasma exchange. The patient experienced repeated episodes of intolerance to fresh frozen plasma (FFP). Switching from\u00a0plasma exchange to\u00a0plasma filtration, remission was attained\u00a0in this unusual case of vaccine-related thrombocytopenia with microangiopathic hemolytic anemia.<\/jats:p>","DOI":"10.1007\/s40620-022-01402-0","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T03:02:27Z","timestamp":1662174147000},"page":"229-232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Semi-selective plasma filtration applied to the treatment of acquired thrombotic thrombocytopenic purpura following\n                    <i>bnt162b2<\/i>\n                    administration"],"prefix":"10.1093","volume":"36","author":[{"given":"Roberta","family":"Fenoglio","sequence":"first","affiliation":[{"name":"CMID-Nephrology and Dialysis Unit (ERK-Net Member), Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin and San Giovanni Bosco Hub Hospital, Piazza del Donatore di Sangue 3, 10054, Turin, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Marchisio","sequence":"additional","affiliation":[{"name":"CMID-Nephrology and Dialysis Unit (ERK-Net Member), Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin and San Giovanni Bosco Hub Hospital, Piazza del Donatore di Sangue 3, 10054, Turin, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Baffa","sequence":"additional","affiliation":[{"name":"CMID-Nephrology and Dialysis Unit (ERK-Net Member), Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin and San Giovanni Bosco Hub Hospital, Piazza del Donatore di Sangue 3, 10054, Turin, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Quattrocchio","sequence":"additional","affiliation":[{"name":"CMID-Nephrology and Dialysis Unit (ERK-Net Member), Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin and San Giovanni Bosco Hub Hospital, Piazza del Donatore di Sangue 3, 10054, Turin, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Roccatello","sequence":"additional","affiliation":[{"name":"CMID-Nephrology and Dialysis Unit (ERK-Net Member), Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin and San Giovanni Bosco Hub Hospital, Piazza del Donatore di Sangue 3, 10054, Turin, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,3]]},"reference":[{"issue":"21","key":"2026012307481345800_CR1","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1182\/blood-2016-10-709857","article-title":"Thrombotic thrombocytopenic purpura","volume":"129","author":"Joly","year":"2017","journal-title":"Blood"},{"issue":"10","key":"2026012307481345800_CR2","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1182\/bloodadvances.2017005124","article-title":"Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015","volume":"1","author":"Page","year":"2017","journal-title":"Blood 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