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Serum galectin-3 (Gal-3) and intestinal fatty acid binding protein (I-FABP) are potential biomarkers of kidney fibrosis and portal hypertension, respectively. We examined whether serum Gal-3 associates with kidney disease severity and serum I-FABP associates with liver disease severity in ARPKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional study of 29 participants with ARPKD (0.2\u201321\u00a0years old) and presence of native kidneys (Gal-3 analyses, n\u2009=\u200918) and\/or native livers (I-FABP analyses, n\u2009=\u200921). Serum Gal-3 and I-FABP were analyzed using enzyme linked immunosorbent assay. Kidney disease severity variables included estimated glomerular filtration rate (eGFR) and height-adjusted total kidney volume (htTKV). Liver disease severity was characterized using ultrasound elastography to measure liver fibrosis, and spleen length and platelet count as markers of portal hypertension. Simple and multivariable linear regression examined associations between Gal-3 and kidney disease severity (adjusted for liver disease severity) and between I-FABP and liver disease severity (adjusted for eGFR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum Gal-3 was negatively associated with eGFR; 1 standard deviation (SD) lower eGFR was associated with 0.795 SD higher Gal-3 level (95% CI \u2212\u00a01.116, \u2212\u00a00.473; p\u2009&amp;lt;\u20090.001). This association remained significant when adjusted for liver disease severity. Serum Gal-3 was not associated with htTKV in adjusted analyses. Overall I-FABP levels were elevated, but there were no linear associations between I-FABP and liver disease severity in unadjusted or adjusted models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum Gal-3 is associated with eGFR in ARPKD, suggesting its value as a possible novel biomarker of kidney disease severity. We found no associations between serum I-FABP and ARPKD liver disease severity despite overall elevated I-FABP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01416-8","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T10:10:55Z","timestamp":1660817455000},"page":"133-145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of galectin-3 and intestinal fatty acid binding protein as serum biomarkers in autosomal recessive polycystic kidney disease"],"prefix":"10.1093","volume":"36","author":[{"given":"Lindsay T.","family":"Fleischer","sequence":"first","affiliation":[{"name":"Cooper Medical School of Rowan University, Camden, NJ, USA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Ballester","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management Core, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohini","family":"Dutt","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Children\u2019s Hospital of Philadelphia, 3401 Civic Center Boulevard, 19104, Philadelphia, PA, USA 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Howarth","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Children\u2019s Hospital of Philadelphia, 3401 Civic Center Boulevard, 19104, Philadelphia, PA, USA 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Poznick","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassa","family":"Darge","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA 4"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Furth","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Children\u2019s Hospital of Philadelphia, 3401 Civic Center Boulevard, 19104, Philadelphia, PA, USA 3"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-6505","authenticated-orcid":false,"given":"Erum A.","family":"Hartung","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Children\u2019s 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