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Furthermore, detachment may differentiate minimal change disease (MCD) cases\u2014which have only podocyte effacement\u2014from early focal segmental glomerulosclerosis (FSGS) in which\u00a0effacement and detachment are\u00a0observed by electron microscopy. Noteworthy, it is not uncommon for early FSGS to present with clinical presentation\u00a0and light microscopy (LM) pictures identical to MCD. In our routine practice, we often find cells that lie freely in Bowman\u2019s space\u00a0by LM. In this study, we try to determine whether these cells are detached podocytes that are worth reporting or just an artifact that can be ignored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To the best of our knowledge, no study has discussed the accuracy of LM in detecting detached podocytes by the routinely used stains. We retrospectively selected 118 cases that were diagnosed as MCD by LM, and searched for detached cells in Bowman\u2019s space in their archived, routinely stained LM slides. After that, we tried to find any correlation between the clinical course,\u00a0detached cells in LM picture and the EM reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LM can significantly detect detached podocytes with a positive predictive value of 93%, specificity of 85%, and sensitivity of 46%. Significant correlations were found between detached cells and degree of proteinuria and late steroid resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u00a0Detecting detached podocytes by LM is a specific finding\n that must be reported whenever detected, as it predicts\u00a0response to steroids and may be able to differentiate MCD from early FSGS by identifying patients who could have podocytopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01456-0","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T01:02:55Z","timestamp":1667955775000},"page":"2313-2324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of detached podocytes in differentiating between minimal change disease and early focal segmental glomerulosclerosis, can we rely on routine light microscopy?"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2636-0966","authenticated-orcid":false,"given":"Mahmoud M.","family":"Sobh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"El Kannishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa","family":"Hamdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Tharwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"1456_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/00041552-200107000-00009","volume":"10","author":"K Tryggvason","year":"2001","unstructured":"Tryggvason K, Wartiovaara J (2001) Molecular basis of glomerular permselectivity. 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