{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:10:54Z","timestamp":1793830254474,"version":"4.6.1"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007658","name":"Baxter Healthcare Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Increased muscle protein catabolism leading to muscle wasting is a prominent feature of the syndrome of protein-energy wasting (PEW) in patients with chronic kidney disease (CKD). PEW and muscle wasting are induced by factors such as inflammation, oxidative stress and metabolic acidosis that activate the\n                    <jats:italic>ubiquitin\u2013proteasome system<\/jats:italic>\n                    , the main regulatory mechanism of skeletal muscle degradation. Whether deficiency of nuclear factor erythroid 2-related factor 2 (NRF2), which regulates expression of antioxidant proteins protecting against oxidative damage triggered by inflammation, may exacerbate PEW has yet to be examined in aging\u00a0patients with CKD. This review focuses on the hypothesis that NRF2 is involved in the maintenance of muscle mass and explores whether sustained activation of NRF2 by non-pharmacological interventions using nutraceutical activators to improve redox homeostasis could be a plausible strategy to prevent skeletal muscle disorders, including muscle wasting, sarcopenia and frailty associated with PEW in aging\u00a0CKD patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s40620-022-01484-w","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T11:45:04Z","timestamp":1667389504000},"page":"2215-2225","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transcription factor NRF2 as potential therapeutic target for preventing muscle wasting in aging chronic kidney disease patients"],"prefix":"10.1093","volume":"35","author":[{"given":"Erika F.","family":"G\u00f3mez-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola Mart\u00edn","family":"del Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cort\u00e9s-Sanabria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mendoza-Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Maria","family":"Avesani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stenvinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4269-4293","authenticated-orcid":false,"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso M.","family":"Cueto-Manzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"1484_CR1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2016.02.021","volume":"98","author":"SK Powers","year":"2016","unstructured":"Powers SK, Morton AB, Ahn B et al (2016) Redox control of skeletal muscle atrophy. Free Radic Biol Med 98:208\u2013217","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"1484_CR2","first-page":"507","volume":"34","author":"C Gracia Iguacel","year":"2014","unstructured":"Gracia Iguacel C, Gonz\u00e1lez Parra E, Barril Cuadrado G et al (2014) Defining protein-energy wasting syndrome in chronic kidney disease: prevalence and clinical implications. Nefrologia 34(4):507\u2013519","journal-title":"Nefrologia"},{"key":"1484_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-020-00840-y","author":"A Sabatino","year":"2020","unstructured":"Sabatino A, Cuppari L, Stenvinkel P et al (2020) Sarcopenia in chronic kidney disease: what have we learned so far? J Nephrol. https:\/\/doi.org\/10.1007\/s40620-020-00840-y","journal-title":"J Nephrol"},{"issue":"6","key":"1484_CR4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1053\/j.jrn.2018.08.006","volume":"28","author":"JJ Carrero","year":"2018","unstructured":"Carrero JJ, Thomas F, Arogundade F et al (2018) Global prevalence of protein-energy wasting in kidney disease\u202f: a meta-analysis of contemporary observational studies from the international society of renal nutrition and metabolism. J Ren Nutr 28(6):380\u2013392","journal-title":"J Ren Nutr"},{"key":"1484_CR5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1152\/japplphysiol.00654.2018","volume":"126","author":"AM Wafi","year":"2019","unstructured":"Wafi AM, Hong J, Rudebush TL et al (2019) Translational control of muscle mass curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF\u202f: Nrf2 and antioxidant mechanisms in skeletal muscle. J Appl Physiol 126:477\u2013486","journal-title":"J Appl Physiol"},{"key":"1484_CR6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.phrs.2015.05.010","volume":"99","author":"V Dutt","year":"2015","unstructured":"Dutt V, Gupta S, Dabur R et al (2015) Skeletal muscle atrophy: potential therapeutic agents and their mechanisms of action. Pharmacol Res 99:86\u2013100","journal-title":"Pharmacol Res"},{"issue":"7","key":"1484_CR7","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/ndt\/15.7.953","volume":"15","author":"P Stenvinkel","year":"2000","unstructured":"Stenvinkel P, Heimb\u00fcrger O, Lindholm B et al (2000) Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant 15(7):953\u2013960","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"1484_CR8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.ki.5002585","volume":"73","author":"D Fouque","year":"2008","unstructured":"Fouque D, Kalantar-Zadeh K, Kopple J et al (2008) A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73(4):391\u2013398","journal-title":"Kidney Int"},{"issue":"2","key":"1484_CR9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/ckj\/sfx134","volume":"11","author":"AC Nixon","year":"2018","unstructured":"Nixon AC, Bampouras TM, Pendleton N et al (2018) Frailty and chronic kidney disease: current evidence and continuing uncertainties. Clin Kidney J 11(2):236\u2013245","journal-title":"Clin Kidney J"},{"issue":"1","key":"1484_CR10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz Jentoft","year":"2019","unstructured":"Cruz Jentoft AJ, Bahat G, Bauer J et al (2019) Sarcopenia: Revised European consensus on definition and diagnosis. Age Ageing 48(1):16\u201331","journal-title":"Age Ageing"},{"issue":"9","key":"1484_CR11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nrneph.2014.112","volume":"10","author":"XH Wang","year":"2014","unstructured":"Wang XH, Mitch WE (2014) Mechanisms of muscle wasting in chronic kidney disease. Nat Rev Nephrol 10(9):504\u2013516","journal-title":"Nat Rev Nephrol"},{"issue":"9","key":"1484_CR12","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/ndt\/gfz193","volume":"35","author":"KA Robinson","year":"2020","unstructured":"Robinson KA, Baker LA, Graham-Brown MPM et al (2020) Skeletal muscle wasting in chronic kidney disease: the emerging role of microRNAs. Nephrol Dial Transpl 35(9):1469\u20131478","journal-title":"Nephrol Dial Transpl"},{"issue":"1","key":"1484_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12882-018-1181-1","volume":"20","author":"YL Lin","year":"2019","unstructured":"Lin YL, Chen SY, Lai YH et al (2019) Angiotensin II receptor blockade is associated with preserved muscle strength in chronic hemodialysis patients. BMC Nephrol 20(1):1\u20137","journal-title":"BMC Nephrol"},{"key":"1484_CR14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.exger.2019.01.022","volume":"119","author":"D Huang","year":"2019","unstructured":"Huang D, Fan S, Chen X et al (2019) Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner. Exp Gerontol 119:61\u201373","journal-title":"Exp Gerontol"},{"key":"1484_CR15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.redox.2018.04.004","volume":"17","author":"B Ahn","year":"2018","unstructured":"Ahn B, Pharaoh G, Premkumar P et al (2018) Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol 17:47\u201358","journal-title":"Redox Biol"},{"key":"1484_CR16","first-page":"gfab031","volume":"6","author":"C Juul-Nielsen","year":"2021","unstructured":"Juul-Nielsen C, Shen J, Stenvinkel P et al (2021) Systematic review of the nuclear factor erythroid 2-related factor 2 (NRF2) system in human chronic kidney disease: alterations, interventions, and relation to morbidity. Nephrol Dial Transpl 6:gfab031","journal-title":"Nephrol Dial Transpl"},{"key":"1484_CR17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41581-020-00345-8","volume":"17","author":"D Mafra","year":"2020","unstructured":"Mafra D, Borges NA, Lindholm B et al (2020) Food as medicine: targeting the uraemic phenotype in chronic kidney disease. Nat Rev Nephrol 17:153\u2013171","journal-title":"Nat Rev Nephrol"},{"key":"1484_CR18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.freeradbiomed.2014.02.023","volume":"71","author":"M Narasimhan","year":"2014","unstructured":"Narasimhan M, Hong J, Atieno N et al (2014) Nrf2 deficiency promotes apoptosis and impairs PAX7\/MyoD expression in aging skeletal muscle cells. Free Radic Biol Med 71:402\u2013414","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"1484_CR19","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.bbagen.2017.12.015","volume":"1862","author":"V Dutt","year":"2018","unstructured":"Dutt V, Saini V, Gupta P et al (2018) S-allyl cysteine inhibits TNF \u03b1-induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochim Biophys Acta Gen Subj 1862(4):895\u2013906","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"5","key":"1484_CR20","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1681\/ASN.2004100842","volume":"17","author":"JL Bailey","year":"2006","unstructured":"Bailey JL, Zheng B, Hu Z et al (2006) Chronic kidney disease causes defects in signaling through the insulin receptor substrate\/phosphatidylinositol 3-kinase\/Akt pathway: implications for muscle atrophy. J Am Soc Nephrol 17(5):1388\u20131394","journal-title":"J Am Soc Nephrol"},{"key":"1484_CR21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-60761-738-9_3","volume":"647","author":"SD Minchin","year":"2010","unstructured":"Minchin SD, Busby SJW (2010) Review of molecular mechanisms involved in the activation of the NRF2-ARE signaling pathway by chemopreventive agents. Methods Mol Biol 647:37\u201374","journal-title":"Methods Mol Biol"},{"issue":"10","key":"1484_CR22","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.3390\/molecules15107266","volume":"15","author":"KA Jung","year":"2010","unstructured":"Jung KA, Kwak MK (2010) The Nrf2 system as a potential target for the development of indirect antioxidants. Molecules 15(10):7266\u20137291","journal-title":"Molecules"},{"key":"1484_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2018.01648","volume":"9","author":"M S\u00e1rk\u00f6zy","year":"2018","unstructured":"S\u00e1rk\u00f6zy M, Kov\u00e1cs ZZA, Kov\u00e1cs MG et al (2018) Mechanisms and modulation of oxidative\/nitrative stress in type 4 cardio-renal syndrome and renal sarcopenia. Front Physiol 9:1\u201319","journal-title":"Front Physiol"},{"issue":"5","key":"1484_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms20051178","volume":"20","author":"CN Receno","year":"2019","unstructured":"Receno CN, Liang C, Korol DL et al (2019) Effects of prolonged dietary curcumin exposure on skeletal muscle biochemical and functional responses of aged male rats. Int J Mol Sci 20(5):1\u201318","journal-title":"Int J Mol Sci"},{"key":"1484_CR25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.freeradbiomed.2015.12.031","volume":"98","author":"O Rom","year":"2016","unstructured":"Rom O, Reznick AZ (2016) The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass. Free Radic Biol Med 98:218\u2013230","journal-title":"Free Radic Biol Med"},{"key":"1484_CR26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2016.02.021","volume":"98","author":"SK Powers","year":"2016","unstructured":"Powers SK, Morton AB, Ahn B et al (2016) Free radical biology and medicine redox control of skeletal muscle atrophy. Free Radic Biol Med 98:208\u2013217","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"1484_CR27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/bj3600143","volume":"360","author":"C Deval","year":"2015","unstructured":"Deval C, Mordier S, Obled C et al (2015) Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting. Biochem J 360(1):143\u2013150","journal-title":"Biochem J"},{"key":"1484_CR28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biochi.2018.10.012","volume":"156","author":"P Chaudhary","year":"2019","unstructured":"Chaudhary P, Sharma YK, Sharma S et al (2019) High altitude mediated skeletal muscle atrophy: Protective role of curcumin. Biochimie 156:138\u2013147","journal-title":"Biochimie"},{"key":"1484_CR29","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1152\/ajpcell.00088.2004","volume":"287","author":"BA Bondesen","year":"2004","unstructured":"Bondesen BA, Mills ST, Kegley KM et al (2004) The COX-2 pathway is essential during early stages of skeletal muscle regeneration. Am J Physiol Cell Physiol 287:475\u2013483","journal-title":"Am J Physiol Cell Physiol"},{"key":"1484_CR30","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jcp.21212","volume":"214","author":"W Shen","year":"2008","unstructured":"Shen W, Li Y, Zhu J (2008) Interaction between macrophages, TGF-\u03b21, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury. J Cell Physiol 214:405\u2013412","journal-title":"J Cell Physiol"},{"key":"1484_CR31","first-page":"1","volume":"2017","author":"X Sun","year":"2017","unstructured":"Sun X, Liu Y, Li C et al (2017) Recent advances of curcumin in the prevention and treatment of renal fibrosis. Biomed Res Int 2017:1\u20139","journal-title":"Biomed Res Int"},{"key":"1484_CR32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1152\/ajprenal.00356.2010","volume":"302","author":"SS Ghosh","year":"2012","unstructured":"Ghosh SS, Krieg R, Massey HD et al (2012) Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5\u20446 nephrectomized rats: role of phospholipase and cyclooxygenase. Am J Physiol Ren Physiol 302:439\u2013454","journal-title":"Am J Physiol Ren Physiol"},{"issue":"4","key":"1484_CR33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ki.2012.84","volume":"82","author":"J Xu","year":"2012","unstructured":"Xu J, Li R, Workeneh B et al (2012) Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486. Kidney Int 82(4):401\u2013411","journal-title":"Kidney Int"},{"issue":"12","key":"1484_CR34","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s11255-016-1425-6","volume":"48","author":"NE Farage","year":"2016","unstructured":"Farage NE, Stockler-Pinto MB, Leal VO et al (2016) NF-\u03baB expression and its association with nutritional status in hemodialysis patients. Int Urol Nephrol 48(12):2089\u20132094","journal-title":"Int Urol Nephrol"},{"key":"1484_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep03625","volume":"4","author":"O Al-Sawaf","year":"2014","unstructured":"Al-Sawaf O, Fragoulis A, Rosen C et al (2014) Nrf2 protects against TWEAK-mediated skeletal muscle wasting. Sci Rep 4:1\u20137","journal-title":"Sci Rep"},{"issue":"12","key":"1484_CR36","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.biochi.2012.07.015","volume":"94","author":"LM Pedruzzi","year":"2012","unstructured":"Pedruzzi LM, Stockler-Pinto MB, Leite M et al (2012) Nrf2-keap1 system versus NF-\u03baB: the good and the evil in chronic kidney disease? Biochimie 94(12):2461\u20132466","journal-title":"Biochimie"},{"issue":"4","key":"1484_CR37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrneph.2017.169","volume":"14","author":"P Stenvinkel","year":"2018","unstructured":"Stenvinkel P, Painer J, Kuro OM et al (2018) Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nat Rev Nephrol 14(4):265\u2013284","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"1484_CR38","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1152\/japplphysiol.00042.2016","volume":"121","author":"MJ Crilly","year":"2016","unstructured":"Crilly MJ, Tryon LD, Erlich AT et al (2016) The role of Nrf2 in skeletal muscle contractile and mitochondrial function. J Appl Physiol 121(3):730\u2013740","journal-title":"J Appl Physiol"},{"issue":"10","key":"1484_CR39","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/hmg\/ddw073","volume":"25","author":"LC Bott","year":"2016","unstructured":"Bott LC, Badders NM, Chen KL et al (2016) A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy. Hum Mol Genet 25(10):1979\u20131989","journal-title":"Hum Mol Genet"},{"issue":"12","key":"1484_CR40","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jdiacomp.2018.09.005","volume":"32","author":"GM Chertow","year":"2018","unstructured":"Chertow GM, Appel GB, Block GA et al (2018) Effects of bardoxolone methyl on body weight, waist circumference and glycemic control in obese patients with type 2 diabetes mellitus and stage 4 chronic kidney disease. J Diabetes Complicat 32(12):1113\u20131117","journal-title":"J Diabetes Complicat"},{"issue":"5","key":"1484_CR41","doi-asserted-by":"crossref","first-page":"F1122","DOI":"10.1152\/ajprenal.00202.2019","volume":"317","author":"C Liu","year":"2019","unstructured":"Liu C, Gidlund E-K, Witasp A et al (2019) Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease. Am J Physiol Physiol 317(5):F1122\u2013F1131","journal-title":"Am J Physiol Physiol"},{"issue":"4","key":"1484_CR42","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s40620-014-0162-0","volume":"28","author":"LM Pedruzzi","year":"2015","unstructured":"Pedruzzi LM, Cardozo LFMF, Daleprane JB et al (2015) Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2. J Nephrol 28(4):495\u2013501","journal-title":"J Nephrol"},{"issue":"10","key":"1484_CR43","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.freeradbiomed.2010.08.010","volume":"49","author":"A Safdar","year":"2010","unstructured":"Safdar A, Tarnopolsky MA (2010) Dysfunctional Nrf2 \u2013 Keap1 redox signaling in skeletal muscle of the sedentary old. Free Radic Biol Med 49(10):1487\u20131493","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"1484_CR44","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.bbadis.2012.02.007","volume":"1822","author":"CJ Miller","year":"2012","unstructured":"Miller CJ, Gounder SS, Kannan S et al (2012) Disruption of Nrf2\/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. Biochim Biophys Acta 1822(6):1038\u20131050","journal-title":"Biochim Biophys Acta"},{"issue":"21","key":"1484_CR45","doi-asserted-by":"crossref","first-page":"21446","DOI":"10.18632\/aging.103896","volume":"12","author":"LH Chung","year":"2020","unstructured":"Chung LH, Liu ST, Huang SM et al (2020) High phosphate induces skeletal muscle atrophy and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signaling. Aging (Albany NY) 12(21):21446\u201321468","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"1484_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14814\/phy2.13998","volume":"7","author":"Y Kitaoka","year":"2019","unstructured":"Kitaoka Y, Tamura Y, Takahashi K et al (2019) Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle. Physiol Rep 7(3):1\u20138","journal-title":"Physiol Rep"},{"key":"1484_CR47","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13243","author":"P Stenvinkel","year":"2021","unstructured":"Stenvinkel P (2021) Mitochondrial dysfunction as part of an inflammatory intermediate phenotype that drives premature ageing. J Intern Med. https:\/\/doi.org\/10.1111\/joim.13243","journal-title":"J Intern Med"},{"issue":"5","key":"1484_CR48","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1053\/j.jrn.2013.11.006","volume":"24","author":"MB Stockler Pinto","year":"2014","unstructured":"Stockler Pinto MB, Fouque D, Soulage CO et al (2014) Indoxyl sulfate and p-cresyl sulfate in chronic kidney disease. Could these toxins modulate the antioxidant Nrf2-Keap1 pathway? J Ren Nutr 24(5):286\u2013291","journal-title":"J Ren Nutr"},{"issue":"2","key":"1484_CR49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/physiolgenomics.00041.2017","volume":"50","author":"QM Chen","year":"2018","unstructured":"Chen QM, Maltagliati AJ (2018) Nrf2 at the heart of oxidative stress and cardiac protection. Physiol Genom 50(2):77\u201397","journal-title":"Physiol Genom"},{"issue":"3","key":"1484_CR50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/MCO.0000000000000455","volume":"21","author":"M Francaux","year":"2018","unstructured":"Francaux M, Deldicque L (2018) Using polyphenol derivatives to prevent muscle wasting. Curr Opin Clin Nutr Metab Care 21(3):159\u2013163","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"1484_CR51","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3390\/nu11030496","volume":"11","author":"D Mafra","year":"2019","unstructured":"Mafra D, Borges N, Alvarenga L et al (2019) Dietary components that may influence the disturbed gut microbiota in chronic kidney disease. Nutrients 11(3):496","journal-title":"Nutrients"},{"issue":"2","key":"1484_CR52","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11357-017-9968-8","volume":"39","author":"AR Konopka","year":"2017","unstructured":"Konopka AR, Laurin JL, Musci RV et al (2017) Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults. GeroScience 39(2):175\u2013186","journal-title":"GeroScience"},{"issue":"3","key":"1484_CR53","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2174\/1871527316666170102120211","volume":"16","author":"Y Sun","year":"2017","unstructured":"Sun Y, Yang T, Leak RK et al (2017) Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases. CNS Neurol Disord Drug Targets 16(3):326\u2013338","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"1484_CR54","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s11033-020-06041-x","volume":"48","author":"T Clifford","year":"2021","unstructured":"Clifford T, Acton JP, Cocksedge SP et al (2021) The efect of dietary phytochemicals on nuclear factor erythroid 2-related factor 2 (Nrf2) activation: a systematic review of human intervention trials. Mol Biol Rep 48:1745\u20131761","journal-title":"Mol Biol Rep"},{"key":"1484_CR55","volume":"239","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Liu X, Fu X et al (2019) Protective effects of epigallocatechin gallate against ischemia reperfusion injury in rat skeletal muscle via activating Nrf2\/HO-1 signaling pathway. Life Sci 239:117014","journal-title":"Life Sci"},{"issue":"9","key":"1484_CR56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cdn\/nzz101","volume":"3","author":"R Kanlaya","year":"2019","unstructured":"Kanlaya R, Thongboonkerd V (2019) Molecular mechanisms of epigallocatechin-3-gallate for prevention of chronic kidney disease and renal fibrosis: preclinical evidence. Curr Dev Nutr 3(9):1\u201310","journal-title":"Curr Dev Nutr"},{"key":"1484_CR57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2011.02.023","volume":"305","author":"H Wang","year":"2011","unstructured":"Wang H, Lai Y, Chan Y et al (2011) Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia. Cancer Lett 305:40\u201349","journal-title":"Cancer Lett"},{"key":"1484_CR58","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.freeradbiomed.2017.04.365","volume":"108","author":"W Sun","year":"2017","unstructured":"Sun W, Liu X, Zhang H et al (2017) Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1. Free Radic Biol Med 108:840\u2013857","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"1484_CR59","first-page":"401","volume":"26","author":"JF Saldanha","year":"2016","unstructured":"Saldanha JF, Leal VO, Rizzetto F et al (2016) Effects of resveratrol supplementation in Nrf2 and NF-\u03baB expressions in nondialyzed chronic kidney disease patients: a randomized, double-blind, placebo-controlled. Crossover Clinical Trial J Ren Nut 26(6):401\u2013406","journal-title":"Crossover Clinical Trial J Ren Nut"},{"issue":"6","key":"1484_CR60","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1158\/1055-9965.EPI-07-0022","volume":"16","author":"DJ Boocock","year":"2007","unstructured":"Boocock DJ, Faust GES, Patel KR et al (2007) Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 16(6):1246\u20131252","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"1484_CR61","doi-asserted-by":"crossref","first-page":"83","DOI":"10.18632\/aging.101361","volume":"10","author":"EN Kim","year":"2018","unstructured":"Kim EN, Lim JH, Kim MY et al (2018) Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. Aging 10(1):83\u201399","journal-title":"Aging"},{"issue":"6","key":"1484_CR62","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1139\/cjpp-2013-0290","volume":"92","author":"E Batistela","year":"2014","unstructured":"Batistela E, Pereira MP, Siqueira JT et al (2014) Decreased rate of protein synthesis, caspase-3 activity, and ubiquitin\u2013proteasome proteolysis in soleus muscles from growing rats fed a low-protein, high-carbohydrate diet. Can J Physiol Pharmacol 92(6):445\u2013454","journal-title":"Can J Physiol Pharmacol"},{"key":"1484_CR63","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.3945\/jn.114.194217","volume":"144","author":"ML Dirks","year":"2014","unstructured":"Dirks ML, Wall BT, Nilwik R et al (2014) Skeletal muscle disuse atrophy is not attenuated by dietary protein supplementation in healthy older men 1, 2. J Nutr 144:1196\u20131203","journal-title":"J Nutr"},{"issue":"6","key":"1484_CR64","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/mus.21578","volume":"41","author":"IL Baptista","year":"2010","unstructured":"Baptista IL, Leal ML, Artioli GG et al (2010) Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases. Muscle Nerve 41(6):800\u2013808","journal-title":"Muscle Nerve"},{"key":"1484_CR65","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/ajpendo.00488.2005","volume":"291","author":"CS Katsanos","year":"2006","unstructured":"Katsanos CS, Kobayashi H, Sheffield Moore M et al (2006) A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 291:381\u2013387","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1484_CR66","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1152\/ajpendo.00353.2011","volume":"302","author":"M Borgenvik","year":"2012","unstructured":"Borgenvik M, Apr\u00f3 W, Blomstrand E et al (2012) Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exercising human muscle Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exerc. Am J Physiol Endocrinol Metab 302:520\u2013521","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"12","key":"1484_CR67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050390","volume":"7","author":"AC Lambertucci","year":"2012","unstructured":"Lambertucci AC, Lambertucci RH, Hirabara SM et al (2012) Glutamine supplementation stimulates protein-synthetic and inhibits protein-degradative signaling pathways in skeletal muscle of diabetic rats. PLoS ONE 7(12):e50390","journal-title":"PLoS ONE"},{"key":"1484_CR68","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2020.108120","volume":"162","author":"P Golpour","year":"2020","unstructured":"Golpour P, Nourbakhsh M, Mazaherioun M et al (2020) Improvement of NRF2 gene expression and antioxidant status in patients with type 2 diabetes mellitus after supplementation with omega-3 polyunsaturated fatty acids: a double-blind randomised placebo-controlled clinical trial. Diabetes Res Clin Pract 162:108120","journal-title":"Diabetes Res Clin Pract"},{"issue":"182","key":"1484_CR69","first-page":"1","volume":"19","author":"SH Son","year":"2021","unstructured":"Son SH, Lee SM, Lee MH et al (2021) Omega-3 fatty acids upregulate SIRT1\/3, activate PGC-1 via deacetylation, and induce Nrf1 Production in 5\/6 nephrectomy rat model. Mar Drugs 19(182):1\u201310","journal-title":"Mar Drugs"},{"issue":"2","key":"1484_CR70","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jcsm.12162","volume":"8","author":"R Yu","year":"2017","unstructured":"Yu R, Chen JA, Xu J et al (2017) Suppression of muscle wasting by the plant-derived compound ursolic acid in a model of chronic kidney disease. J Cachexia Sarcopenia Muscle 8(2):327\u2013341","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"1484_CR71","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.cmet.2011.03.020","volume":"13","author":"SD Kunkel","year":"2011","unstructured":"Kunkel SD, Suneja M, Ebert SM et al (2011) mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell Metab 13(6):627\u2013638","journal-title":"Cell Metab"},{"issue":"1","key":"1484_CR72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.physbeh.2017.03.040","volume":"176","author":"PE Bunney","year":"2017","unstructured":"Bunney PE, Zink AN, Holm AA et al (2017) Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet. Physiol Behav 176(1):139\u2013148","journal-title":"Physiol Behav"},{"key":"1484_CR73","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/j.1476-5381.2012.01854.x","volume":"166","author":"Y Pan","year":"2012","unstructured":"Pan Y, Wang Y, Cai L et al (2012) Inhibition of high glucose- induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury. Br J Pharmacol 166:1169\u20131182","journal-title":"Br J Pharmacol"},{"key":"1484_CR74","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbacli.2016.02.003","volume":"5","author":"BK McFarlin","year":"2016","unstructured":"McFarlin BK, Venable AS, Henning AL et al (2016) Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin 5:72\u201378","journal-title":"BBA Clin"},{"key":"1484_CR75","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2174\/1871530316666160613115221","volume":"16","author":"J He","year":"2016","unstructured":"He J, Xie H, Wu S (2016) Dietary supplementation of curcumin alleviates NF-\u03baB-dependent skeletal muscle wasting in rat. Endocrine Metab Immune Disord Drug Targets 16:140\u2013147","journal-title":"Endocrine Metab Immune Disord Drug Targets"},{"key":"1484_CR76","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2147\/JIR.S110873","volume":"9","author":"K Sahin","year":"2016","unstructured":"Sahin K, Pala R, Tuzcu M et al (2016) Curcumin prevents muscle damage by regulating NF-\u03baB and Nrf2 pathways and improves performance: an in vivo model. J Inflamm Res 9:147\u2013154","journal-title":"J Inflamm Res"},{"issue":"15","key":"1484_CR77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18632\/oncotarget.7773","volume":"7","author":"HA Parsons","year":"2016","unstructured":"Parsons HA, Baracos VE, Hong DS et al (2016) The effects of curcumin (diferuloylmethane) on body composition of patients with advanced pancreatic cancer. Oncotarget 7(15):1\u201371","journal-title":"Oncotarget"},{"issue":"11","key":"1484_CR78","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1681\/ASN.2019121277","volume":"31","author":"L Zhang","year":"2020","unstructured":"Zhang L, Chen Q, Chen Z et al (2020) Mechanisms regulating muscle protein synthesis in CKD. J Am Nephrol 31(11):2573\u20132587","journal-title":"J Am Nephrol"},{"key":"1484_CR79","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3390\/antiox11061112","volume":"11","author":"AK Aranda Rivera","year":"2022","unstructured":"Aranda Rivera AK, Cruz Gregorio A, Pedraza-Chaverri J et al (2022) Nrf2 activation in chronic kidney disease: promises and pitfalls. Antioxidants 11:1112","journal-title":"Antioxidants"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-022-01484-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-022-01484-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-022-01484-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:55:24Z","timestamp":1777564524000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/35\/9\/2215\/8325904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":79,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1484"],"URL":"https:\/\/doi.org\/10.1007\/s40620-022-01484-w","relation":{},"ISSN":["1724-6059"],"issn-type":[{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"19 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"BL was employed by Baxter Healthcare Corporation. None of the other authors declare relevant financial interests that would represent a conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}