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Based on pathophysiological risk factors influencing kidney magnesium reabsorption, a magnesium depletion score (MDS) was developed. Using MDS as a novel indicator for assessing body magnesium status, we hypothesized that it was associated with clinical prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective population-based cohort study using data from the National Health and Nutrition Examination Survey 1999\u20132014 to explore the impact of MDS on the clinical outcomes of CKD patients. Propensity score-matched\u00a0analyses were conducted to increase comparability. The primary outcome was all-cause mortality, and the secondary outcomes were cardiovascular-cause and cancer-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After\u00a0propensity score matching, 3294 CKD patients were divided into 2 groups: MDS\u2009\u2264\u20092 (N\u2009=\u20091647), and MDS\u2009&amp;gt;\u20092 (N\u2009=\u20091647). During a median follow-up of 75\u00a0months, Kaplan\u2013Meier analyses showed that MDS\u2009&amp;gt;\u20092 was associated with worse 5- and 10-year overall survival (78.5% vs 73.4%; 53.1% vs 43.1%, P\u2009&amp;lt;\u20090.001).\u00a0After adjusting for confounding variables, MDS was found to be an independent risk factor for all-cause mortality (HR:1.34, 95% CI 1.20\u20131.50, P\u2009&amp;lt;\u20090.001). MDS\u2009&amp;gt;\u20092 was also associated with higher cardiovascular-cause mortality (16.2% VS 11.6%, P\u2009=\u20090.005). Multivariate competing risk analysis revealed that MDS\u2009&amp;gt;\u20092 was an independent risk factor (HR: 1.33, 95% CI 1.06\u20131.66, P\u2009=\u20090.012). Subgroup analyses reported that MDS\u2009&amp;gt;\u20092 increased all-cause mortality and cardiovascular-cause mortality only in patients with inadequate magnesium intake (P\u2009&amp;lt;\u20090.001, P\u2009&amp;lt;\u20090.001) but not in those with adequate intake (P\u2009=\u20090.068, P\u2009=\u20090.920).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A magnesium depletion score\u2009&amp;gt;\u20092 was independently associated with higher long-term cardiovascular-cause and all-cause mortality in CKD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01489-5","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T05:02:42Z","timestamp":1668488562000},"page":"755-765","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Magnesium Depletion Score is Associated with Long-Term Mortality in Chronic Kidney Diseases: A Prospective Population-Based Cohort Study"],"prefix":"10.1093","volume":"36","author":[{"given":"Saifu","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Urology\/Institute of Urology, West China Hospital, Sichuan University, Guoxue Alley 37#, Wuhou District, 610041, Chengdu, Sichuan, China 1"},{"name":"Organ Transplantation Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department 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May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This work was supported by grants from 1.3.5 Project for Disciplines of Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University (2021HXFH007). The funders had no role in study design, data collection or analysis, preparation of the manuscript, or the decision to publish.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest disclosures (for all authors)"}},{"value":"This study involved secondary data analysis of a nationally representative publicly available dataset. The study we conducted was exempt from institutional review for this reason.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval Statement"}},{"value":"All data are publicly available at [\n                      \n                      ].","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}}]}}