{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:13:13Z","timestamp":1791724393243,"version":"4.3.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":1165,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81770736"],"award-info":[{"award-number":["81770736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81770736"],"award-info":[{"award-number":["81770736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipoprotein glomerulopathy (LPG) is a rare autosomal dominant kidney disease caused by pathogenic mutations in the APOE gene. Collagen type III glomerulopathy (CG) is a sporadic condition in adults characterized by abnormal accumulation of type III collagen in the subendothelial space and mesangium of the glomerulus. We report the first case of both LPG and CG in a 21-year-old male. A search of the literature found no confirmed reports of these two concomitant\u00a0nephropathies. The patient presented with hypertension, proteinuria, hematuria and hyperlipidemia. Renal pathology showed lipid vacuoles in the enlarged glomerular capillary loops and type III collagen in the segmental mesangial area and on the inner side of the glomerular basement membrane by electron microscopy. Whole-exome sequencing revealed a heterozygous mutation (c.127C&amp;gt;T; p. Arg43Cys) in exon 3 of the APOE gene, known as the APOE-Kyoto of LPG. In addition, two heterozygous COL4A4 mutations (c.4715C&amp;gt;T in exon 47 and c.5065\u00a0T&amp;gt;C in exon 48) were observed, the first one was suspected pathogenic and the other one was uncertain significant. There is no special treatment for these diseases. The patient was treated with lipid-lowering agents, renin\u2013angiotensin\u2013aldosterone system inhibition and tripterygium glycosides. The patient received double-filtration plasmapheresis and immunoadsorption therapy when renal function deteriorated dramatically. Immunoadsorption was beneficial for this patient.<\/jats:p>","DOI":"10.1007\/s40620-022-01491-x","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T04:02:57Z","timestamp":1668225777000},"page":"663-667","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The first case of lipoprotein glomerulopathy complicated with collagen type III glomerulopathy and literature review"],"prefix":"10.1093","volume":"36","author":[{"given":"Huixia","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, Hubei, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, Hubei, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, Hubei, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, Hubei, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-4103","authenticated-orcid":false,"given":"Jing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, Hubei, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"2026012001322481800_CR1","doi-asserted-by":"publisher","first-page":"684814","DOI":"10.3389\/fped.2021.684814 34513758","article-title":"Case report: a pediatric case of lipoprotein glomerulopathy in china and literature review","volume":"9","author":"Song","year":"2021","journal-title":"Front Pediatr"},{"issue":"6","key":"2026012001322481800_CR2","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1016\/j.ekir.2021.03.887 34169215","article-title":"Collagen type III glomerulopathy","volume":"6","author":"Wilson","year":"2021","journal-title":"Kidney Int Rep"},{"issue":"1","key":"2026012001322481800_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/ndtplus\/sfr144 26069739","article-title":"Collagenofibrotic glomerulopathy-a review","volume":"5","author":"Duggal","year":"2012","journal-title":"Clin Kidney J"},{"issue":"1","key":"2026012001322481800_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13256-022-03302-0 35193676","article-title":"A novel apolipoprotein e mutation, apoe ganzhou (Arg43cys), in a Chinese son and his father with lipoprotein glomerulopathy: two case reports","volume":"16","author":"Wang","year":"2022","journal-title":"J Med Case Rep"},{"issue":"8","key":"2026012001322481800_CR5","doi-asserted-by":"publisher","first-page":"e1281","DOI":"10.1002\/mgg3.1281 32441489","article-title":"Clinical and genetic analysis of lipoprotein glomerulopathy patients caused by apoe mutations","volume":"8","author":"Yang","year":"2020","journal-title":"Mol Genet Genomic Med"},{"issue":"1","key":"2026012001322481800_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12967-021-02765-x 33663537","article-title":"Lipoprotein glomerulopathy induced by apoe kyoto mutation in apoe-deficient mice","volume":"19","author":"Wu","year":"2021","journal-title":"J Transl Med"},{"issue":"2","key":"2026012001322481800_CR7","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1159\/000111828 18046082","article-title":"Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy","volume":"28","author":"Luo","year":"2008","journal-title":"Am J Nephrol"},{"issue":"2","key":"2026012001322481800_CR8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00428-002-0738-2 12596068","article-title":"Collagenofibrotic glomerulopathy with a widespread expression of type-V collagen","volume":"442","author":"Morita","year":"2003","journal-title":"Virchows Arch"},{"issue":"6","key":"2026012001322481800_CR9","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/j.athoracsur.2005.12.065 16731157","article-title":"pravastatin improves remodeling and cardiac function after myocardial infarction by an antiinflammatory mechanism rather than by the induction of angiogenesis","volume":"81","author":"Li","year":"2006","journal-title":"Ann Thorac Surg"}],"container-title":["Journal of 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May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This is an observational study. The Ethics Committee of Wuhan Union Hospital has confirmed that no ethical approval is required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in Figure A, B, C.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}