{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T04:24:15Z","timestamp":1772598255173,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP-2019-04-8822"],"award-info":[{"award-number":["IP-2019-04-8822"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"crossref","award":["IP-2019-04-8822"],"award-info":[{"award-number":["IP-2019-04-8822"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Several histologic classifications are used in the evaluation of IgA vasculitis nephritis (IgAVN), however, to date, no studies have determined which one has the strongest association with the severity of IgAVN\u00a0and, as a consequence, its outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Patients included in the study were diagnosed with IgAV and IgAVN in seven tertiary university medical centers in Croatia, Italy and Israel. The International Study of Kidney Disease in Children (ISKDC), Haas, Oxford, and Semiquantitative classification (SQC) classifications were used in the analysis\u00a0and description of renal biopsy.\u00a0Time from biopsy to outcome evaluation was a statistically significant factor in outcome prediction that was used to define the base model, and was a covariate in all the tested\u00a0models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-seven patients were included in this study. The SQC classification proved to be the best\u00a0one in outcome prediction, followed by the Oxford classification. The ISKDC and Haas classifications could not predict renal outcome. The Oxford parameters for mesangial hypercellularity and tubular atrophy, as well as the SQC parameters for cellular crescents showed an independent statistically significant contribution to outcome prediction. High level of twenty-four hour protein excretion was associated with a higher grade in the Oxford, SQC and ISKDC classifications. Endocapillary proliferation was positively associated with the Pediatric Vasculitis Activity Score (PVAS) at diagnosis, while tubular atrophy was negatively associated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SQC, followed by the Oxford classification were found to provide the best classifications of renal biopsy analysis in patients to predict the outcome in patients with IgAVN. Cellular crescents, mesangial hypercellularity and tubular atrophy showed significant contributions, indicating that active and chronic variables should be included in the estimation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01509-4","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T01:40:54Z","timestamp":1669772454000},"page":"441-449","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Semiquantitative classification (SQC) and Oxford classifications predict poor renal outcome better than The International Study of Kidney Disease in Children (ISKDC) and Haas in patients with IgAV nephritis: a multicenter study"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-6670","authenticated-orcid":false,"given":"Nastasia","family":"Kifer","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Pediatrics, Referral Centre for Pediatric and Adolescent Rheumatology Republic of Croatia, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Ki\u0161pati\u0107eva 12, 10000, Zagreb, Croatia 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1038-0540","authenticated-orcid":false,"given":"Stela","family":"Bulimbasic","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1092-6491","authenticated-orcid":false,"given":"Mario","family":"Sestan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Pediatrics, Referral Centre for Pediatric and Adolescent Rheumatology Republic of Croatia, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Ki\u0161pati\u0107eva 12, 10000, Zagreb, Croatia 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5360-8333","authenticated-orcid":false,"given":"Martina","family":"Held","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Pediatrics, Referral Centre for Pediatric and Adolescent Rheumatology Republic of Croatia, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Ki\u0161pati\u0107eva 12, 10000, Zagreb, Croatia 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-3484","authenticated-orcid":false,"given":"Domagoj","family":"Kifer","sequence":"additional","affiliation":[{"name":"Department of Biophysics, University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6555-2613","authenticated-orcid":false,"given":"Sasa","family":"Srsen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Paediatrics, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-2664","authenticated-orcid":false,"given":"Ana","family":"Gudelj Gracanin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Hospital Holly Spirit, University of Zagreb School of Medicine, Zagreb, Croatia 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-6476","authenticated-orcid":false,"given":"Merav","family":"Heshin-Bekenstein","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Service, Dana Dwek Children\u2019s Hospital, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9292-7601","authenticated-orcid":false,"given":"Teresa","family":"Giani","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy 7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1345-1279","authenticated-orcid":false,"given":"Rolando","family":"Cimaz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy 7"},{"name":"ASST Pini-CTO, Milan, Italy 8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-6460","authenticated-orcid":false,"given":"Alenka","family":"Gagro","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Zagreb, University of Osijek, Medical Faculty Osijek, Osijek, Croatia 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-3375","authenticated-orcid":false,"given":"Marijan","family":"Frkovi\u0107","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Pediatrics, Referral Centre for Pediatric and Adolescent Rheumatology Republic of Croatia, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Ki\u0161pati\u0107eva 12, 10000, Zagreb, Croatia 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Coric","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1728-4260","authenticated-orcid":false,"given":"Marija","family":"Jelusic","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Pediatrics, Referral Centre for Pediatric and Adolescent Rheumatology Republic of Croatia, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Ki\u0161pati\u0107eva 12, 10000, Zagreb, Croatia 1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"2026012110172635800_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2022.853724","article-title":"New insights and challenges associated with IgA vasculitis and IgA vasculitis with nephritis\u2014is it time to change the paradigm of the most common systemic vasculitis in childhood?","volume":"10","author":"Jelusic","year":"2022","journal-title":"Front Pediatr"},{"key":"2026012110172635800_CR2","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/S0140-6736(02)11279-7 12401245","article-title":"Incidence of Henoch-Schonlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins","volume":"360","author":"Gardner-Medwin","year":"2002","journal-title":"Lancet"},{"key":"2026012110172635800_CR3","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1136\/annrheumdis-2020-218649 33208346","article-title":"Geospatial clustering of childhood IgA vasculitis and IgA vasculitis-associated nephritis","volume":"80","author":"Sapina","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"2026012110172635800_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12969-019-0311-z","article-title":"Different histological classifications for Henoch-Sch\u00f6nlein purpura nephritis: which one should be used?","volume":"17","author":"Jelusic","year":"2019","journal-title":"Pediatr Rheumatol"},{"key":"2026012110172635800_CR5","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1159\/000516765 34098552","article-title":"Persistence and severity of cutaneous manifestations in IgA vasculitis is associated with development of IgA vasculitis nephritis in children","volume":"238","author":"Sestan","year":"2022","journal-title":"Dermatology"},{"key":"2026012110172635800_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/bmj.2.6078.11","article-title":"Prognosis of Henoch-Schonlein nephritis in children","volume":"2","author":"Counahan","year":"1977","journal-title":"BMJ"},{"key":"2026012110172635800_CR7","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0272-6386(97)90456-X 9186068","article-title":"Histologic subclassification of IgA nephropathy: a clinicopathologic study of 244 cases","volume":"29","author":"Haas","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"2026012110172635800_CR8","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/ki.2009.243 19571791","article-title":"The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification","volume":"76","author":"Cattran","year":"2009","journal-title":"Kidney Int"},{"key":"2026012110172635800_CR9","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.kint.2017.02.003 28341274","article-title":"Oxford classification of IgA nephropathy 2016: an update from the IgA nephropathy classification Working Group","volume":"91","author":"Trimarchi","year":"2017","journal-title":"Kidney Int"},{"key":"2026012110172635800_CR10","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s00467-017-3608-5 28197887","article-title":"The ISKDC classification and a new semiquantitative classification for predicting outcomes of Henoch-Sch\u00f6nlein purpura nephritis","volume":"32","author":"Koskela","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"2026012110172635800_CR11","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1093\/rheumatology\/kez041 30879080","article-title":"European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis\u2014the SHARE initiative","volume":"58","author":"Ozen","year":"2019","journal-title":"Rheumatology"},{"key":"2026012110172635800_CR12","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1136\/annrheumdis-2012-202111 23100606","article-title":"Disease activity assessment in childhood vasculitis: development and preliminary validation of the Paediatric Vasculitis Activity Score (PVAS)","volume":"72","author":"Dolezalova","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"2026012110172635800_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108341 34775367","article-title":"Clinical predictive model for the 1-year remission probability of IgA vasculitis nephritis","volume":"101","author":"He","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"2026012110172635800_CR14","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/S0140-6736(02)09835-5 12241872","article-title":"The adult kidney 24 years after childhood Henoch-Sch\u00f6nlein purpura: a retrospective cohort study","volume":"360","author":"Ronkainen","year":"2002","journal-title":"Lancet"},{"key":"2026012110172635800_CR15","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1007\/s00431-021-04065-4 33934234","article-title":"Association of kidney biopsy findings with short- and medium-term outcomes in children with moderate-to-severe IgA vasculitis nephritis","volume":"180","author":"Clav\u00e9","year":"2021","journal-title":"Eur J Pediatr"},{"key":"2026012110172635800_CR16","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00467-019-04363-y 31696358","article-title":"Histological prognostic factors in children with Henoch-Sch\u00f6nlein purpura nephritis","volume":"35","author":"Delbet","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"2026012110172635800_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2021.658845","article-title":"Using MEST-C Scores and the International Study of Kidney Disease in Children Classification to Predict Outcomes of Henoch-Sch\u00f6nlein Purpura Nephritis in Children","volume":"9","author":"Wang","year":"2021","journal-title":"Front Pediatr"},{"key":"2026012110172635800_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s11255-021-02861-3 33905044","article-title":"Predictability of the Oxford classification of IgA nephropathy in Henoch-Schonlein purpura nephritis","volume":"54","author":"Luo","year":"2022","journal-title":"Int Urol Nephrol"},{"key":"2026012110172635800_CR19","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1093\/ndt\/gfy302 30418652","article-title":"Is there long-term value of pathology scoring in immunoglobulin A nephropathy? A validation study of the Oxford Classification for IgA Nephropathy (VALIGA) update","volume":"35","author":"Coppo","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"2026012110172635800_CR20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12882-020-1691-5","article-title":"MEST-C pathological score and long-term outcomes of child and adult patients with Henoch-Sch\u00f6nlein purpura nephritis","volume":"21","author":"Yun","year":"2020","journal-title":"BMC Nephrol"},{"key":"2026012110172635800_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13000-019-0818-0","article-title":"Updated Oxford classification and the international study of kidney disease in children classification: application in predicting outcome of Henoch-Sch\u00f6nlein purpura nephritis","volume":"14","author":"Huang","year":"2019","journal-title":"Diagn Pathol"},{"key":"2026012110172635800_CR22","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/15513815.2019.1658245 31490094","article-title":"Patient outcomes of Henoch-Sch\u00f6nlein purpura nephritis according to the new semiquantitative classification","volume":"39","author":"Yel","year":"2020","journal-title":"Fetal Pediatr Pathol"},{"key":"2026012110172635800_CR23","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00467-019-04415-3 31797094","article-title":"Prediction of renal outcome in Henoch-Sch\u00f6nlein nephritis based on biopsy findings","volume":"35","author":"Koskela","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"2026012110172635800_CR24","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1186\/s12882-018-1117-9","article-title":"Significance of histological crescent formation in patients with IgA vasculitis (Henoch-Sch\u00f6nlein purpura)-related nephritis: a cohort in the adult Chinese population","volume":"19","author":"Huang","year":"2018","journal-title":"BMC Nephrol"},{"key":"2026012110172635800_CR25","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1007\/s00467-020-04818-7 33219450","article-title":"IgA vasculitis nephritis in children and adults: one or different entities?","volume":"36","author":"Peruzzi","year":"2021","journal-title":"Pediatr Nephrol"},{"key":"2026012110172635800_CR26","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1053\/j.ajkd.2006.02.178 16731294","article-title":"Predictors of outcome in Henoch-Sch\u00f6nlein Nephritis in Children and Adults","volume":"47","author":"Coppo","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"2026012110172635800_CR27","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/ki.2009.168 19571790","article-title":"The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility","volume":"76","author":"Roberts","year":"2009","journal-title":"Kidney Int"},{"key":"2026012110172635800_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127767","article-title":"24h urinary protein levels and urine protein\/creatinine ratios could probably forecast the pathological classification of HSPN","volume":"10","author":"Ye","year":"2015","journal-title":"PLoS\u00a0One"},{"key":"2026012110172635800_CR29","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12969-021-00616-z","article-title":"IgA vasculitis nephritis clinical course and kidney biopsy\u2014national study in children","volume":"19","author":"Mizerska-Wasiak","year":"2021","journal-title":"Pediatr Rheumatol"},{"key":"2026012110172635800_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223218","article-title":"Risk factors associated with IgA vasculitis with nephritis (Henoch\u2013Sch\u00f6nlein purpura nephritis) progressing to unfavorable outcomes: a meta-analysis","volume":"14","author":"Shi","year":"2019","journal-title":"PLoS\u00a0One"},{"key":"2026012110172635800_CR31","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/ki.2014.63","article-title":"Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments","volume":"86","author":"Coppo","year":"2014","journal-title":"Kidney Int"}],"updated-by":[{"DOI":"10.1007\/s40620-022-01545-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T00:00:00Z","timestamp":1670112000000}}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-022-01509-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-022-01509-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/36\/2\/441\/66514258\/joneph_36_2_1509.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-022-01509-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/36\/2\/441\/66514258\/joneph_36_2_1509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:17:35Z","timestamp":1769008655000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/36\/2\/441\/8304795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,11,30]]},"published-print":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.1007\/s40620-022-01509-4","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2022,11,30]]},"assertion":[{"value":"1 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s40620-022-01545-0","URL":"https:\/\/doi.org\/10.1007\/s40620-022-01545-0","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}