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Since crystals are able to activate the inflammasome and lead to cell injury, crystalluria might worsen ADPKD natural history, acting as a third hit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Bern ADPKD registry is a prospective observational cohort study. Height-adjusted total kidney volume (ht-TKV) was measured at baseline and every 3\u00a0years. Twenty-four hour urinary solute excretions collected at baseline and eGFR measurements over time were included in this analysis. Twenty-four hour urinary supersaturations (SS) for calcium oxalate, calcium phosphate and uric acid were calculated using EQUIL-2. Linear regression models were used to assess linear and non-linear associations between slopes of ht-TKV and eGFR with SSs and 24\u00a0h urinary solute excretions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-seven participants (mean age 45.0 [SD 12.9] years, eGFR 76.4 [28.3] mL\/min\/1.73 m2) were included, with a median follow-up of 4\u00a0years. The median slopes of ht-TKV and eGFR were 3.9 percent\/year and 2.9\u00a0mL\/min\/1.73 m2\/year, respectively. SS for uric acid showed a direct, linear association (p value for linearity 0.035) with ht-TKV slope. When analyzing individual components, urinary uric acid, ammonium, magnesium and sulfate were all directly associated with ht-TKV slope. Urinary sulfate was also directly associated with eGFR slope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Uric acid supersaturation and several other\u00a0urinary components are identified as\u00a0predictors of cyst growth in patients with ADPKD. Future studies with a dedicated design are needed to investigate the pathophysiological mechanisms underlying these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01540-5","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T12:02:31Z","timestamp":1671278551000},"page":"1011-1018","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of urinary supersaturations for lithogenic salts in the progression of autosomal dominant polycystic kidney disease"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1379-022X","authenticated-orcid":false,"given":"Pietro Manuel","family":"Ferraro","sequence":"first","affiliation":[{"name":"U.O.S. Terapia Conservativa Della Malattia Renale Cronica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168, Rome, Italy 1"},{"name":"Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Bargagli","sequence":"additional","affiliation":[{"name":"U.O.S. Terapia Conservativa Della Malattia Renale Cronica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168, Rome, Italy 1"},{"name":"Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy 2"},{"name":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland 3"},{"name":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Faller","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel A.","family":"Anderegg","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, 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