{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:16:14Z","timestamp":1769066174419,"version":"3.49.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007338","name":"All-India Institute of Medical Sciences","doi-asserted-by":"publisher","award":["I-632"],"award-info":[{"award-number":["I-632"]}],"id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007338","name":"All-India Institute of Medical Sciences","doi-asserted-by":"crossref","award":["I-632"],"award-info":[{"award-number":["I-632"]}],"id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urinary NGAL (neutrophil gelatinase-associated lipocalin) levels have been shown to predict renal damage in various medical conditions. The present study was conducted to study the role of urinary NGAL levels in children with bladder exstrophy\u2013epispadias complex post single-stage total reconstruction (SSTR) as markers of early renal function\u00a0reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Urine samples were collected from children with bladder exstrophy before SSTR (Group A, n\u2009=\u200911), 5\u00a0years post SSTR (Group B, n\u2009=\u200940) and controls (Group C, n\u2009=\u200941) and stored at \u2212\u200920\u00a0\u00b0C. NGAL levels were estimated using double antibody sandwich ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean NGAL levels in Groups A, B and C were 1.39, 34.24 and 2.58\u00a0ng\/ml, respectively. Mean NGAL levels among Group B subjects with glomerular filtration rate (GFR)\u2009\u2265\u200980\u00a0ml\/min\/1.73\u00a0m2 body surface area (BSA) was 29.8\u00a0ng\/ml, while it was 31.74\u00a0ng\/ml in those with GFR\u2009&amp;lt;\u200980\u00a0ml\/min. Urine samples were also evaluated 6\u00a0months post SSTR. Mean NGAL at 6\u00a0months was 6.76\u00a0ng\/ml, while at 12\u00a0months it was 30.3\u00a0ng\/ml, remaining\u2009&amp;gt;\u200930\u00a0ng\/ml at 18 and 24\u00a0months. Dimercaptosuccinic acid (DMSA) scans did not show any scarring, and GFR\u00a0on diethylenetriamine pentaacetate (DTPA) scans remained stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increasing levels of urinary NGAL following bladder-exstrophy\u00a0and\u00a0epispadias complex repair suggest that NGAL detects the earliest signs of renal damage even before any deterioration is observed in DMSA and\/or DTPA-GFR scans. Further studies with an adequate sample size and periodic measurement of NGAL need to be performed before any definitive conclusion can be drawn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-022-01548-x","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:02:36Z","timestamp":1671764556000},"page":"1409-1414","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative and postoperative urinary NGAL levels in children with bladder exstrophy"],"prefix":"10.1093","volume":"36","author":[{"given":"Alisha","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minu","family":"Bajpai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachit","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India 1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"2026012110194326900_CR1","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1097\/00005392-199809020-00062 9719305","article-title":"Combined bladder closure 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