{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:16:13Z","timestamp":1787732173552,"version":"build-2784847793"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In late 2018, the production of 51Chromium-labelled ethylenediamine tetra-acetic acid (51Cr-EDTA), a validated and widely used radio-isotopic tracer for measuring glomerular filtration rate, was halted. Technetium-99m-diethylenetriaminepentaacetic acid (99mTc-DTPA) has been validated for GFR measurement with a single bolus injection, a procedure not suitable in patients with extracellular compartment hyperhydration. In such cases, a bolus followed by continuous infusion of the tracer is required. The aim of this study was to evaluate whether 99mTc-DTPA with the infusion protocol can replace 51Cr-EDTA for GFR measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective single centre study during February and March 2019. All patients referred for GFR measurement received both radiotracers simultaneously: 51Cr-EDTA and 99mTc-DTPA bolus and continuous infusion were administered concomitantly through the same intravenous route. Over four and a half hours, plasma and urine samples were collected to calculate urinary and plasma clearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-two patients were included (mean age 63.4\u2009\u00b1\u200917.5\u00a0years; 68% men). Mean urinary clearance of 51Cr-EDTA and 99mTc-DTPA was 52.4\u2009\u00b1\u200922.5\u00a0mL\/min and 52.8\u2009\u00b1\u200922.6\u00a0mL\/min, respectively (p\u2009=\u20090.47), with a mean bias of 0.39\u2009\u00b1\u20092.50\u00a0mL\/min, an accuracy within 10% of 100%\u00a0(95% CI\u00a0100; 100) and a Pearson correlation coefficient of 0.994. Mean plasma clearance of 51Cr-EDTA and 99mTc-DTPA was 54.8\u2009\u00b1\u200920.9\u00a0mL\/min and 54.4\u2009\u00b1\u200920.9\u00a0mL\/min, respectively (p\u2009=\u20090.61), with a mean bias of \u2212\u00a00.43\u2009\u00b1\u20093.89\u00a0mL\/min, an accuracy within 10% of 77%\u00a0(95% CI\u00a059; 91) and a Pearson correlation coefficient of 0.983.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Urinary and plasma clearance of 99mTc-DTPA can be used with the infusion protocol to measure GFR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-023-01612-0","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T02:02:26Z","timestamp":1682301746000},"page":"2457-2465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of 99mTc-DTPA and 51Cr-EDTA for glomerular filtration rate measurement with the continuous infusion method"],"prefix":"10.1093","volume":"36","author":[{"given":"Clara","family":"Balouzet","sequence":"first","affiliation":[{"name":"Radiopharmacie, Pharmacie, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique-H\u00f4pitaux de Paris, Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Michon-Colin","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, Paris, France 2"},{"name":"Explorations fonctionnelles r\u00e9nales, Physiologie, 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The authors have conflict of interest to declare related to this study. Dr. Balouzet reports non-financial support from Curium, outside the submitted work, Pr. Courbebaisse reports grants from Biohealth (Italy), and Advicenne (France), and personal fees from Alnylam (France), outside the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was classified as non-interventional by the DRCI (D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l\u2019Innovation) of APHP (Assistance Publique\u2014H\u00f4pitaux de Paris).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The study was approved by our local Ethics Committee (CERAPHP.5, IRB registration #00011928), and for scientific use, all data were anonymized. Research was conducted in accordance with good clinical practices and the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"All patients received oral and written information about the study before inclusion, and signed informed consent.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}