{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:07:23Z","timestamp":1786982843861,"version":"build-2736575974"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004824","name":"Dansk Nefrologisk Selskab","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004915","name":"Nyreforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020219","name":"Helen og Ejnar Bj\u00f8rnows Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal Library, Copenhagen University Library"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Calcific uremic arteriolopathy is a life-threatening cutaneous condition in patients with chronic kidney disease. Often, clinical diagnosis is accompanied by histopathologic evaluations demonstrating vascular calcium deposits. We aimed to investigate the presence of cutaneous calcifications in non-lesional tissue in patients with chronic kidney disease, and the relation to systemic vascular calcification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the presence of cutaneous vascular calcifications in non-lesional skin biopsies from patients with current or previous calcific uremic arteriolopathy and patients with different stages of chronic kidney disease without calcific uremic arteriolopathy, and explored their association with vascular calcification in other vascular beds. Systemic vascular calcification was examined by mammography and lumbar X-ray.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-nine adults were enrolled (current or previous calcific uremic arteriolopathy,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099; end-stage chronic kidney disease,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912; chronic kidney disease stage 3b-4,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912; healthy controls,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). All calcific uremic arteriolopathy patients had end-stage kidney disease. Cutaneous vascular calcifications were not present in any of the non-lesional skin punch biopsies. Breast arterial calcification was demonstrated in patients with calcific uremic arteriolopathy (75%) and chronic kidney disease (end-stage 67% and stage 3b-4 25%, respectively), but in none of the controls. All chronic kidney disease patients had systemic calcification on lumbar X-ray (median score 21, 22, and 15 in patients with calcific uremic arteriolopathy, end-stage kidney disease and chronic kidney disease stage 3b-4). The serum calcification propensity was significantly different between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite a high burden of systemic vascular calcification, cutaneous calcium deposits in non-lesional tissue could not be demonstrated histopathologically in patients with chronic kidney disease (with or without current or previous calcific uremic arteriolopathy). Further studies to determine whether these findings are representative or attributed to other factors are warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-023-01707-8","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T07:02:51Z","timestamp":1689750171000},"page":"1991-1999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cutaneous vascular calcifications in patients with chronic kidney disease and calcific uremic arteriolopathy: a cross-sectional study"],"prefix":"10.1093","volume":"36","author":[{"given":"Anne Kristine","family":"R\u00f8ndbjerg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Gyldenl\u00f8ve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorrit","family":"Krustrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Rix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Vejborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lonn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas Rye","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-7901","authenticated-orcid":false,"given":"Ditte","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"1707_CR1","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1056\/NEJMra1505292","volume":"378","author":"SU Nigwekar","year":"2018","unstructured":"Nigwekar SU, Thadhani R, Brandenburg VM (2018) Calciphylaxis. N Engl J Med 378:1704\u20131714. https:\/\/doi.org\/10.1056\/NEJMra1505292","journal-title":"N Engl J Med"},{"key":"1707_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/DAD.0000000000001519","volume":"42","author":"KM Chaudet","year":"2020","unstructured":"Chaudet KM, Dutta P, Nigwekar SU, Nazarian RM (2020) Calciphylaxis-associated cutaneous vascular calcification in noncalciphylaxis patients. Am J Dermatopathol 42:557\u2013563. https:\/\/doi.org\/10.1097\/DAD.0000000000001519","journal-title":"Am J Dermatopathol"},{"key":"1707_CR3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.kint.2018.03.016","volume":"94","author":"CL Ellis","year":"2018","unstructured":"Ellis CL, O\u2019Neill WC (2018) Questionable specificity of histologic findings in calcific uremic arteriolopathy. Kidney Int 94:390\u2013395. https:\/\/doi.org\/10.1016\/j.kint.2018.03.016","journal-title":"Kidney Int"},{"key":"1707_CR4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12882-020-01928-0","volume":"21","author":"I Ruderman","year":"2020","unstructured":"Ruderman I, Hewitson TD, Smith ER et al (2020) Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease. BMC Nephrol 21:279. https:\/\/doi.org\/10.1186\/s12882-020-01928-0","journal-title":"BMC Nephrol"},{"key":"1707_CR5","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/ndt\/gfw025","volume":"31","author":"VM Brandenburg","year":"2016","unstructured":"Brandenburg VM, Evenepoel P, Floege J et al (2016) Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis? Nephrol Dial Transplant 31:1211\u20131219. https:\/\/doi.org\/10.1093\/ndt\/gfw025","journal-title":"Nephrol Dial Transplant"},{"key":"1707_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/s0021-9150(97)00106-8","volume":"132","author":"LI Kauppila","year":"1997","unstructured":"Kauppila LI, Polak JF, Cupples LA et al (1997) New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis 132:245\u2013250. https:\/\/doi.org\/10.1016\/s0021-9150(97)00106-8","journal-title":"Atherosclerosis"},{"key":"1707_CR7","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1681\/ASN.2012030240","volume":"23","author":"A Pasch","year":"2012","unstructured":"Pasch A, Farese S, Graber S et al (2012) Nanoparticle-based test measures overall propensity for calcification in serum. J Am Soc Nephrol 23:1744\u20131752. https:\/\/doi.org\/10.1681\/ASN.2012030240","journal-title":"J Am Soc Nephrol"},{"key":"1707_CR8","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/CIRCULATIONAHA.105.588723","volume":"113","author":"JH Ix","year":"2006","unstructured":"Ix JH, Shlipak MG, Brandenburg VM et al (2006) Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation 113:1760\u20131767. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.588723","journal-title":"Circulation"},{"key":"1707_CR9","doi-asserted-by":"publisher","first-page":"31496","DOI":"10.1074\/jbc.272.50.31496","volume":"272","author":"W Jahnen-Dechent","year":"1997","unstructured":"Jahnen-Dechent W, Schinke T, Trindl A et al (1997) Cloning and targeted deletion of the mouse fetuin gene. J Biol Chem 272:31496\u201331503. https:\/\/doi.org\/10.1074\/jbc.272.50.31496","journal-title":"J Biol Chem"},{"key":"1707_CR10","first-page":"461","volume":"15","author":"H Selye","year":"1961","unstructured":"Selye H, Grasso S, Dieudonne JM (1961) On the role of adjuvants in calciphylaxis. Q Rev Allergy Appl Immunol 15:461\u2013465","journal-title":"Q Rev Allergy Appl Immunol"},{"key":"1707_CR11","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/DAD.0000000000000824","volume":"39","author":"TY Chen","year":"2017","unstructured":"Chen TY, Lehman JS, Gibson LE et al (2017) Histopathology of calciphylaxis: cohort study with clinical correlations. Am J Dermatopathol 39:795\u2013802. https:\/\/doi.org\/10.1097\/DAD.0000000000000824","journal-title":"Am J Dermatopathol"},{"key":"1707_CR12","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1093\/eurheartj\/ehu163","volume":"35","author":"P Lanzer","year":"2014","unstructured":"Lanzer P, Boehm M, Sorribas V et al (2014) Medial vascular calcification revisited: review and perspectives. Eur Heart J 35:1515\u20131525. https:\/\/doi.org\/10.1093\/eurheartj\/ehu163","journal-title":"Eur Heart J"},{"key":"1707_CR13","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1016\/j.jcmg.2018.07.035","volume":"12","author":"R Quispe","year":"2019","unstructured":"Quispe R, Al-Rifai M, Di Carlo PA et al (2019) Breast arterial calcium: a game changer in women\u2019s cardiovascular health? JACC Cardiovasc Imaging 12:2538\u20132548. https:\/\/doi.org\/10.1016\/j.jcmg.2018.07.035","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-023-01707-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-023-01707-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-023-01707-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:53:02Z","timestamp":1777564382000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/36\/7\/1991\/8304329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,19]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["1707"],"URL":"https:\/\/doi.org\/10.1007\/s40620-023-01707-8","relation":{},"ISSN":["1724-6059"],"issn-type":[{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,19]]},"assertion":[{"value":"12 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A Pasch is an employee and stockholder of Calciscon AG, Biel, Switzerland, which commercializes the T50 test. DH, MD, DK, MR, IV, LL, NJ, LS, DH have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the latest revision of the Helsinki Declaration. The protocol was approved by the research ethics committee of the Capital Region of Denmark (H-15003900) and the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all participants before screening.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}