{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:48:01Z","timestamp":1769064481053,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Use of continuous renal replacement therapy in children receiving anti-infective drugs may lead to inappropriate concentrations with risks related to treatment failure, toxicity and emergence of multidrug-resistant bacteria. We aimed to describe anti-infective prescribing practices in critically ill children undergoing continuous renal replacement therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An online survey to assess continuous renal replacement therapy, anti-infective prescribing and therapeutic drug monitoring practices was sent by e-mail to physicians working in pediatric intensive care units through the French-speaking Group of Pediatric Intensive Care and Emergency medicine (GFRUP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From April 1st, 2021 to May 1st, 2021, 26\/40 pediatric intensive care units participated in the survey, corresponding to a response rate of 65%. Twenty-one were located in France and five abroad. All pediatric intensive care units administered continuous renal replacement therapy, primarily with Prismaflex\u2122 System. Anti-infective prescriptions were adjusted to the presence of continuous renal replacement therapy in 23 (88%) pediatric intensive care units mainly according to molecular weight in 6 (23%), molecule protein binding in 6 (23%) and elimination routes in 15 (58%) including residual diuresis in 9 (35%), to the continuous renal replacement therapy flow in 6 (23%) and to the modality of continuous renal replacement therapy used in 15 (58%), pediatric intensive care units. There was broad variability among pediatric intensive care units and among physicians within the same unit. Barriers to therapeutic drug monitoring were mainly an excessive delay in obtaining results in 11 (42%) and the lack of an on-site laboratory in 8 (31%) pediatric intensive care units.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our survey reported wide variability in anti-infective prescribing practices in children undergoing continuous renal replacement therapy, thus highlighting a gap in knowledge and the need for education and recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-023-01762-1","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T06:02:50Z","timestamp":1694498570000},"page":"2541-2547","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-infective prescribing practices in critically ill children on continuous renal replacement therapy: a multicenter survey of French-speaking countries"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-505X","authenticated-orcid":false,"given":"Micha\u00ebl","family":"Thy","sequence":"first","affiliation":[{"name":"Department of Intensive Care and Infectious Diseases, AP-HP, Universit\u00e9 Paris Cit\u00e9, Bichat Hospital, Paris, France 1"},{"name":"Pediatric Intensive Care Unit, AP-HP, Universit\u00e9 Paris Cit\u00e9, Necker-Enfants Malades Hospital, Paris, France 2"},{"name":"EA 7323-Pharmacology and Therapeutic Evaluation in Children and Pregnant Women, Universit\u00e9 Paris Cit\u00e9, Paris, France 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Naudin","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, H\u00f4pital Robert Debr\u00e9, AP-HP, Universit\u00e9 Paris Diderot, Paris, France 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Genuini","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, H\u00f4pital Robert Debr\u00e9, AP-HP, Universit\u00e9 Paris Diderot, Paris, France 4"},{"name":"Pediatric Intensive Care Transport Unit, H\u00f4pital Robert Debr\u00e9, AP-HP, Universit\u00e9 Paris Diderot, Paris, France 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Leteurtre","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille, ULR 2694-METRICS: \u00c9valuation des Technologies de Sant\u00e9 et des Pratiques M\u00e9dicales, Lille, France 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Recher","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille, ULR 2694-METRICS: \u00c9valuation des Technologies de Sant\u00e9 et des Pratiques M\u00e9dicales, Lille, France 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Oualha","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, AP-HP, Universit\u00e9 Paris Cit\u00e9, Necker-Enfants Malades Hospital, Paris, France 2"},{"name":"EA 7323-Pharmacology and Therapeutic Evaluation in Children and Pregnant Women, Universit\u00e9 Paris Cit\u00e9, Paris, France 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Groupe Francophone de R\u00e9animation et d\u2019Urgences P\u00e9diatriques (GFRUP)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"2026012110233448900_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S1473-3099(14)71003-5","article-title":"Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002\u201313: a multicentre retrospective cohort study","volume":"15","author":"Schlapbach","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"2026012110233448900_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ijantimicag.2013.11.006","article-title":"Dose optimisation of antibiotics in children: application of pharmacokinetics\/pharmacodynamics in paediatrics","volume":"43","author":"Downes","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"2026012110233448900_CR3","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s00134-020-06050-1","article-title":"Antimicrobial therapeutic drug monitoring in critically ill adult patients: a position paper","volume":"46","author":"Abdul-Aziz","year":"2020","journal-title":"Intensive Care Med"},{"key":"2026012110233448900_CR4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.diagmicrobio.2014.04.007","article-title":"How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?","volume":"79","author":"Felton","year":"2014","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2026012110233448900_CR5","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1097\/CCM.0b013e318241e553","article-title":"Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study","volume":"40","author":"Roberts","year":"2012","journal-title":"Crit Care Med"},{"key":"2026012110233448900_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11095-016-2033-y","article-title":"Clinical pharmacology studies in critically ill children","volume":"34","author":"Thakkar","year":"2017","journal-title":"Pharm Res"},{"key":"2026012110233448900_CR7","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1007\/s13546-014-0917-6","article-title":"\u00c9puration extrar\u00e9nale en r\u00e9animation adulte et p\u00e9diatrique. 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