{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:29:10Z","timestamp":1769066950609,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":784,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005765","name":"Universidade de Lisboa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005765","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005765","name":"Universidade de Lisboa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005765","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autologous hematopoietic stem cell transplant plays an important role in multiple myeloma (MM) treatment. Increasing incidence of MM and growing awareness of acute kidney injury (AKI) as a complication of hematopoietic stem cell transplant results in the need to better understand AKI in these patients. We aimed to evaluate incidence, risk factors and 5-year prognostic impact of AKI in MM patients undergoing autologous hematopoietic stem cell transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study. AKI was defined by the KDIGO classification using creatinine and urinary output criteria. We used survival analysis methods considering competing events for risk factors and disease-free survival, Cox proportional regression for overall survival and stepwise regression methods for multivariable models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed data regarding\u00a0143 patients. The cumulative incidence of\u00a0AKI and moderate-to-severe AKI was 49.7% and 14.1%, respectively. Factors with independent impact on AKI were obesity (HR: 1.83, 95% CI 1.07\u20133.11; p\u2009=\u20090.026), Hematopoietic cell transplantation\u2014specific comorbidity index (HCT-CI)\u2009\u2265\u20092 (HR: 1.85, 95% CI 1.08\u20133.17), chronic kidney disease (CKD) (HR: 2.06, 95% CI 1.05\u20134.04), amyloidosis (HR: 2.25, 95% CI 1.25\u20134.06), mucositis grade 3\u20134 (HR: 2.19, 95% CI 1.25\u20133.86) and exposure to nephrotoxic drugs (HR: 2.0856, 95% CI 1.04\u20134.19). Moderate-to-severe AKI had an impact (HR: 1.62, 95% CI 1.15\u20132.31) on 5-year overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acute kidney injury affects almost half of MM patients undergoing autologous hematopoietic stem cell transplantation, and reduction in\u00a0urinary output allows early diagnosis in almost a quarter of the patients. Obesity, HCT-CI\u2009\u2265\u20092, CKD, amyloidosis, mucositis grade 3\u20134 and exposure to nephrotoxic drugs are significant risk factors. Moderate-to-severe AKI is associated with lower 5-year overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-023-01809-3","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T04:04:10Z","timestamp":1701230650000},"page":"419-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute kidney injury in multiple myeloma patients undergoing autologous hematopoietic stem cell transplant: a\u00a0cohort study"],"prefix":"10.1093","volume":"37","author":[{"given":"Natacha","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Centro Hospitalar Universit\u00e1rio Lisboa Norte, EPE, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Centro Hospitalar Universit\u00e1rio Lisboa Norte, EPE, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Branco","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Centro Hospitalar Universit\u00e1rio Lisboa Norte, EPE, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Martins","sequence":"additional","affiliation":[{"name":"Division of Haematology, Centro Hospitalar Universit\u00e1rio Lisboa Norte, EPE, Lisbon, Portugal 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ant\u00f3nio","family":"Lopes","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Centro Hospitalar Universit\u00e1rio Lisboa Norte, EPE, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal 1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"2026012110461109000_CR1","doi-asserted-by":"publisher","first-page":"e670","DOI":"10.1016\/S2352-3026(22)00165-X 35843248","article-title":"The epidemiological landscape of multiple myeloma: a global cancer registry estimate of disease burden, risk factors, and temporal trends","volume":"9","author":"Huang","year":"2022","journal-title":"Lancet Haematol"},{"key":"2026012110461109000_CR2","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1001\/jamaoncol.2018.2128 29800065","article-title":"Global burden of multiple myeloma: a systematic analysis for the global burden of disease study 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June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The results presented in this article have not been published previously in whole or part. There are no conflicts nor competing interests. No support\u00a0in the form of grants and\/or equipment and drugs was received.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"According to institutional guidelines and waived the requirement to obtain any informed consent due to its retrospective and non-interventional nature.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Committee"}}]}}