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Multivariate linear regression models were fitted to assess the association of estimated glomerular filtration rate (eGFR) and albuminuria categories with physical performance test outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 7396 participants were included. Compared to eGFR 60\u201390\u00a0ml\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      , values\u2009&lt;\u200960\u00a0ml\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      were associated with significantly shorter 6-min walk distance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u2212 13.04\u00a0m, 95% confidence intervals-CI \u2212 19.95; \u2212 6.13), worse timed chair rise stand test time (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : 0.91\u00a0s, 95% CI 0.36; 1.47), lower maximal grip (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u2212 0.83\u00a0kg, 95% CI \u2212 1.50; \u2212 0.15) and elbow flexion (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u2212 3.64 Nm, 95% CI \u2212 7.11; \u2212 0.16) strength. Additionally, eGFR\u2009&gt;\u200990\u00a0ml\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      was linked to significantly shorter 6-min walk distance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u2212 6.13\u00a0m, 95% CI \u2212 9.44; \u2212 2.82). Urinary albumin excretion\u2009&gt;\u200930\u00a0mg\/24\u00a0h was associated with shorter 6-min walk distance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u2212 12.48\u00a0m, 95% CI \u2212 18.28; \u2212 6.68), worse timed chair rise stand test time (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : 0.51\u00a0s, 95% CI 0.11; 1.06), lower maximal grip (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u2212 1.34\u00a0kg, 95% CI \u2212 1.91; \u2212 0.76) and elbow flexion strength (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u2212 3.31\u00a0Nm, 95% CI \u2212 5.80; \u2212 0.82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reduced eGFR and higher albuminuria levels were associated with worse physical performance, especially shorter 6-min walk distance and lower muscle strength. The relationship between eGFR and physical function was non-linear, with also high eGFR values being associated with worse performance, especially in the six-minute walk test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-024-01933-8","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T12:02:05Z","timestamp":1712664125000},"page":"2293-2306","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of kidney function with physical performance: the Maastricht study"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5088-5458","authenticated-orcid":false,"given":"Ioannis","family":"Bellos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaragdi","family":"Marinaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pagona","family":"Lagiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis N.","family":"Boletis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Koster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen M. 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