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All other authors have no financial interest to report. All authors have seen and agree with the contents of the manuscript. We certify that the submission is original work and is not under review at any other publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experimental protocols were reviewed and approved by Boston Children\u2019s Hospital Institutional Animal Care and Use Committee and were conducted in compliance with all relevant ethical regulations for animal testing under research protocol number 00001522.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No humans were involved in this study. We have provided the reference to our approved animal protocol in the ethical statement.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"For this type of study formal consent is not required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}