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The\u00a0risk factors for AKI after\u00a0traumatic hemorrhagic shock\u00a0remain unclear. The aim of this study was to investigate the risk factors for AKI after traumatic hemorrhagic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a ten-year retrospective cohort study of patients who experienced\u00a0traumatic hemorrhagic shock between January 2013 and April 2023. Patient characteristics and clinical data were recorded for 417 patients. The outcome was the occurrence of AKI, defined as a serum creatinine increase of \u2265\u20090.3\u00a0mg\/dL (\u2265\u200926.5\u00a0\u03bcmol\/L) within 48\u00a0h, or an increase to 1.5 times the baseline, or a urine volume of &lt;\u00a00.5\u00a0mL\/(kg h.). Risk factors for AKI were tested by logistic regression\u00a0models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of AKI after traumatic hemorrhagic shock\u00a0was 29.3% (122\/417 patients). Multivariable analysis revealed that the independent risk factors for AKI\u00a0included age (OR, 1.048; 95% CI, 1.022\u20131.074;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), B-type natriuretic peptide (OR, 1.002; 95% CI, 1.000\u20131.004;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041), sepsis (OR, 4.536; 95% CI, 1.651\u201312.462;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) and acute myocardial injury (OR, 2.745; 95% CI, 1.027\u20137.342;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044). Road traffic accidents (OR, 0.202; 95% CI, 0.076\u20130.541;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), mean arterial pressure (OR, 0.972; 95% CI, 0.950\u20130.995;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), and base excess (OR, 0.842; 95% CI, 0.764\u20130.929;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) were negatively correlated with AKI. The area under the receiver operating characteristic (ROC)\u00a0curve\u00a0for prediction by this\u00a0model was 0.85\u00a0(95% CI, 0.81\u20130.90).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of AKI after\u00a0traumatic hemorrhagic shock\u00a0was 29.3%\u00a0in our series. Indicators of blood\u00a0perfusion, sepsis and acute myocardial injury may be independent risk factors for AKI after\u00a0traumatic hemorrhagic shock. Early detection and effective intervention on these risk factors could reduce the occurrence of AKI and improve outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-024-02035-1","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:33:07Z","timestamp":1724394787000},"page":"2337-2346","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Incidence and risk factors for acute kidney injury after traumatic hemorrhagic shock: A 10-year retrospective cohort study"],"prefix":"10.1093","volume":"37","author":[{"given":"Xiujuan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"2035_CR1","doi-asserted-by":"publisher","DOI":"10.1097\/JTN.0b013e318286620","author":"MW Anderson","year":"2013","unstructured":"Anderson MW, Watson GA (2013) Traumatic shock: the fifth shock. 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