{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T05:19:48Z","timestamp":1768022388096,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":435,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The precise role of anti-neutrophil cytoplasmic antibodies (ANCAs) in the pathologic course of crescentic lupus nephritis (LN) remains unclear. Our study aimed to assess whether ANCA-positive serology in patients with LN and crescents is associated with different clinicopathologic features and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the records of 658 patients diagnosed with LN between 2010 and 2022. Among them, 64 (9.7%) patients who had complete follow-up and clinical data were reclassified as crescentic glomerulonephritis. Of these, 11 patients with incomplete ANCA data and 7 patients with less than 10 glomeruli under light microscopy were excluded; ultimately, 46 patients were enrolled: 12 with ANCA positivity and 34 with ANCA negativity. Clinicopathological characteristics and outcomes were analysed and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our data did not reveal any differences in clinical or laboratory parameters or histopathological features except for a significantly higher level of proteinuria or proportion of nephrotic syndrome (p\u2009&amp;lt;\u20090.05) at presentation before biopsy in the ANCA-negative group than in the ANCA-positive group,and a lower level of serum albumin (p\u2009&amp;lt;\u20090.05) in the ANCA-negative group than in the ANCA-positive group. No significant differences in complete remission or partial response were detected between the two groups based on the 2021 KDIGO criterion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Short-term follow-up (average follow-up time of less than 3 years) did not reveal any difference in outcomes between ANCA-positive and ANCA-negative crescentic LN. However, the role of ANCAs in the pathological course of crescentic lupus nephropathy and the effect of ANCAs on long-term outcomes remain to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-024-02085-5","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T07:02:04Z","timestamp":1728543724000},"page":"2191-2200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The uncertain correlation of ANCAs in patients with lupus nephritis and crescents, an experience from Chinese centers"],"prefix":"10.1093","volume":"37","author":[{"given":"Qiong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People\u2019s Hospital), Taiyuan, China 1"},{"name":"Shanxi Genetic Engineering Center for Experimental Animal Models, Taiyuan, China 2"},{"name":"Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People\u2019s Hospital, Taiyuan, China 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zibo Municipal Hospital (Binzhou Medical College Affiliated Hospital), Zibo, China 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People\u2019s Hospital), Taiyuan, China 1"},{"name":"Shanxi Genetic Engineering Center for Experimental Animal Models, Taiyuan, China 2"},{"name":"Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People\u2019s Hospital, Taiyuan, China 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congjuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yankun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People\u2019s Hospital), Taiyuan, China 1"},{"name":"Shanxi Genetic Engineering Center for Experimental Animal Models, Taiyuan, China 2"},{"name":"Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People\u2019s Hospital, Taiyuan, China 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People\u2019s Hospital), Taiyuan, China 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November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the ethical principles stated in the Declaration of Helsinki and was approved by the ethics committee of Shanxi Provincial People\u2019s Hospital (reference numbers: (2021) Shanxi Medical Ethics Review No.159). The Ethics Committee of Zibo MunicipalHospita (NO.2021.021). The Ethics Committee of the Affiliated Hospital of Qingdao University (NO.QYFY255306).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The study was conducted in accordance with the principles contained in the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"The patients\/participants provided their written informed consent to participate in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent to participate"}}]}}