{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:31:15Z","timestamp":1787761875744,"version":"build-2784847793"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Idiopathic inflammatory myopathies represent a spectrum of autoimmune disorders primarily characterized by muscle inflammation. While renal involvement in idiopathic inflammatory myopathies has historically been considered rare, recent findings indicate a prevalence of approximately 21\u201323%. Renal manifestations in idiopathic inflammatory myopathies are generally secondary to acute renal injury from rhabdomyolysis or, more rarely, occur through autoimmune mechanisms leading to glomerulonephritis. Here, we present the case of a 21-year-old male diagnosed with idiopathic inflammatory myopathy positive for anti-Jo antibodies and concurrent C3 glomerulonephritis, which improved following Rituximab therapy. The description of this case provides insights for future research into the role of alternative complement pathway dysregulation in idiopathic inflammatory myopathy-associated C3 glomerulopathy.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-024-02148-7","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T11:33:40Z","timestamp":1734176020000},"page":"733-737","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Idiopathic inflammatory myopathy and C3 glomerulopathy: a rare association"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5222-4431","authenticated-orcid":false,"given":"Elisa","family":"Longhitano","sequence":"first","affiliation":[{"name":"Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, A.O.U. \u201cG.Martino\u201d, University of Messina, 98125, Messina, Italy 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bellone","sequence":"additional","affiliation":[{"name":"Unit of Interne Medicine, Department of Clinical and Experimental Medicine, A.O.U. \u201cG.Martino\u201d, University of Messina, 98125, Messina, Italy 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cernaro","sequence":"additional","affiliation":[{"name":"Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, A.O.U. \u201cG.Martino\u201d, University of Messina, 98125, Messina, Italy 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Squadrito","sequence":"additional","affiliation":[{"name":"Unit of Interne Medicine, Department of Clinical and Experimental Medicine, A.O.U. \u201cG.Martino\u201d, University of Messina, 98125, Messina, Italy 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Santoro","sequence":"additional","affiliation":[{"name":"Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, A.O.U. \u201cG.Martino\u201d, University of Messina, 98125, Messina, Italy 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,14]]},"reference":[{"issue":"11","key":"2026012110515605200_CR1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s41584-023-01033-0 37803078","article-title":"Epidemiology of the idiopathic inflammatory myopathies","volume":"19","author":"Khoo","year":"2023","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"2026012110515605200_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41572-021-00321-x 34857798","article-title":"Idiopathic inflammatory myopathies","volume":"7","author":"Lundberg","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"2026012110515605200_CR3","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1111\/imj.15358 34155760","article-title":"Idiopathic inflammatory myopathies: a review","volume":"51","author":"Ashton","year":"2021","journal-title":"Intern Med J"},{"issue":"4\u20135","key":"2026012110515605200_CR4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.autrev.2014.01.022 24424190","article-title":"Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review","volume":"13","author":"Mahler","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"12","key":"2026012110515605200_CR5","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1001\/jamaneurol.2018.2598 30208379","article-title":"Development of a new classification system for idiopathic inflammatory myopathies based on clinical manifestations and myositis-specific autoantibodies","volume":"75","author":"Mariampillai","year":"2018","journal-title":"JAMA Neurol"},{"issue":"1","key":"2026012110515605200_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s12016-015-8524-5 26590948","article-title":"Renal Involvement in Idiopathic Inflammatory Myopathies","volume":"52","author":"Cucchiari","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"issue":"2","key":"2026012110515605200_CR7","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1742-1241.2004.00248.x 15854195","article-title":"Renal involvement in patients with polymyositis and dermatomyositis","volume":"59","author":"Yen","year":"2005","journal-title":"Int J Clin Pract"},{"issue":"1","key":"2026012110515605200_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/MD.0000000000000015 24378741","article-title":"The spectrum of renal involvement in patients with inflammatory myopathies","volume":"93","author":"Couvrat-Desvergnes","year":"2014","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"2026012110515605200_CR9","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.kint.2020.09.033 33137339","article-title":"Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis","volume":"99","author":"Boudhabhay","year":"2021","journal-title":"Kidney Int"},{"key":"2026012110515605200_CR10","doi-asserted-by":"publisher","first-page":"1051609","DOI":"10.3389\/fimmu.2022.1051609 36578492","article-title":"Efficacy and safety of rituximab treatment in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis","volume":"13","author":"Zhen","year":"2022","journal-title":"Front Immunol"},{"issue":"3","key":"2026012110515605200_CR11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41581-018-0107-2 30692664","article-title":"C3 glomerulopathy - understanding a rare complement-driven renal disease","volume":"15","author":"Smith","year":"2019","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"2026012110515605200_CR12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/antiox10010060 33418934","article-title":"Regulation of complement activation by heme oxygenase-1 (HO-1) in kidney injury","volume":"10","author":"Detsika","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"2026012110515605200_CR13","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.3389\/fimmu.2018.03008 30619356","article-title":"Heme drives susceptibility of glomerular endothelium to complement overactivation due to inefficient upregulation of heme oxygenase-1","volume":"9","author":"May","year":"2018","journal-title":"Front Immunol"}],"container-title":["Journal of 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August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"On behalf of all authors, the corresponding author states that there are no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval for reporting individual cases or case series is not required. The authors\u00a0state that this research was conducted in accordance with the Helsinki Declaration as revised in 2008.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"In reporting this case, written informed consent was obtained from the patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent to participate"}}]}}