{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:25:12Z","timestamp":1792009512618,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is associated with several adverse\u00a0cardiovascular outcomes, including coronary heart disease, heart failure, and arrhythmias. The severity\u00a0of\u00a0arterial calcifications predicts the risk of coronary heart disease and increases the risk of premature cardiovascular death. In experimental models, vitamin K1 supplementation\u00a0appears to reduce coronary artery calcifications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center clinical trial (NCT04247087 on 07\/09\/2019), we randomized 60 Mexican patients on\u00a0chronic hemodialysis and\u2009a coronary calcification score\u00a0&amp;gt;\u200910 Agatston units to receive 10\u00a0mg intravenous vitamin K1 or placebo at the end of the hemodialysis session\u00a0thrice weekly for 12\u00a0months. The primary outcome was the progression of coronary artery calcifications as assessed by the absolute change in Agatston and coronary calcium volume scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The baseline coronary calcium score was\u00a0112.50 (14-2027) Agatston units in the vitamin K1 group and \u00a0177 (10-2843); Agatston units in the placebo group (p\u2009=\u20090.71), and after 12\u00a0months, the coronary calcium score in the vitamin K1 group was\u00a078.50 (10-1915) \u00a0Agatston units in the vitamin K1 group versus \u00a0344 (10-3323); Agatston units (p\u2009=\u20090.05) in the placebo group.\u00a0Progression of coronary calcification was 20.8% in the vitamin K1 group versus 44% in the placebo group, with a relative risk (RR) of 0.45 (CI 95% 0.18\u20131.15).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the Mexican hemodialysis cohort enrolled in this study\u00a0intravenous vitamin K1 supplementation\u00a0reduced the progression of coronary artery calcifications by 55% compared with placebo over a 12-month follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-024-02154-9","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T07:56:56Z","timestamp":1734335816000},"page":"511-519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of vitamin K1 supplementation\u00a0on coronary calcifications in hemodialysis\u00a0patients: a randomized controlled 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Universidad de Guanajuato, Le\u00f3n, Guanajuato, M\u00e9xico 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Baron-Manzo","sequence":"additional","affiliation":[{"name":"Radiology Departament, Unidad Medica de Alta Especialidad, Hospital de Especialidades No. 1, Centro M\u00e9dico Nacional del Baj\u00edo, Le\u00f3n, Guanajuato, M\u00e9xico 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1342-7085","authenticated-orcid":false,"given":"Texar Alfonso","family":"Pereyra-Nobara","sequence":"additional","affiliation":[{"name":"Director of Health Education and Research, Unidad Medica de Alta Especialidad, Hospital de Especialidades No. 1, Centro M\u00e9dico Nacional del Baj\u00edo, Le\u00f3n, Guanajuato, M\u00e9xico 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7295-3666","authenticated-orcid":false,"given":"Luis Ricardo","family":"Hinojosa-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Radiology Departament, Unidad Medica de Alta Especialidad, Hospital de Especialidades No. 1, Centro M\u00e9dico Nacional del Baj\u00edo, Le\u00f3n, Guanajuato, M\u00e9xico 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5838-8709","authenticated-orcid":false,"given":"Sergio Edgardo","family":"Escalante-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Unidad Medica de Alta Especialidad, Hospital de Especialidades No. 1, Centro M\u00e9dico Nacional del Baj\u00edo, Le\u00f3n, Guanajuato, M\u00e9xico 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0049-0110","authenticated-orcid":false,"given":"Mario Alberto","family":"Castillo-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Unidad Medica de Alta Especialidad, Hospital 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