{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:53:51Z","timestamp":1777870431369,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001792","name":"James Cook University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001792","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal cell carcinoma (RCC) is a common malignancy, and nephrectomy is the mainstay of treatment for non-metastatic disease. The choice of surgery depends on the risks of oncologic recurrence, kidney function decline, and perioperative complications. This study aimed to identify factors associated with adverse post-operative outcomes in RCC patients undergoing nephrectomy at Townsville University Hospital (TUH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, quality assessment study of all adult patients undergoing either open or laparoscopic, partial, or radical nephrectomy for suspected RCC at TUH between January 1, 2016, and December 31, 2020. Patients were identified from the Queensland Health Admitted Data Collection, with a median follow-up time of 39\u00a0months post-operatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty patients were included; 71.7% underwent radical nephrectomy, and 63.3% were treated with a laparoscopic approach. Adverse kidney function outcomes were identified in 76.7% of patients. In the first 30\u00a0days post-nephrectomy, the reduction in estimated glomerular filtration rate (eGFR) in the radical nephrectomy group was more than double that in the partial nephrectomy group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The rise in average serum creatinine post-radical nephrectomy was more than six times that post-partial nephrectomy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). This discrepancy in kidney function persisted up to three years post-operatively. No significant differences in RCC recurrence, post-operative cardiovascular events, or mortality were observed between partial nephrectomy and radical nephrectomy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.665,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.420).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The balance strongly favours partial nephrectomy despite its underutilisation for patients undergoing nephrectomy for suspected non-metastatic RCC at TUH. Urology teams should weigh the factors favouring radical nephrectomy against the risks of nearly universal renal function decline in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-024-02173-6","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T22:46:41Z","timestamp":1736203601000},"page":"1357-1368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A clinical audit of adverse post-nephrectomy outcomes in renal cell carcinoma patients at a tertiary hospital in Queensland, Australia"],"prefix":"10.1093","volume":"38","author":[{"given":"Julia Chequer","family":"de Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkat","family":"Vangaveti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Biros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8752-2551","authenticated-orcid":false,"given":"Andrew J.","family":"Mallett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"2173_CR1","doi-asserted-by":"publisher","first-page":"S166","DOI":"10.21037\/tau.2018.10.13","volume":"8","author":"RJ Ellis","year":"2018","unstructured":"Ellis RJ (2018) Chronic kidney disease after nephrectomy: a clinically-significant entity? 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This approval included exemption review and approval from the Townsville Hospital and Health Service Human Research Ethics Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This article contains study with human participants. The study was performed in accordance with the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"A waiver of consent was granted in accordance with the Queensland Hospital and Health Boards Act (Sect.\u00a0150; 2011) and Australia\u2019s National Statement on Ethical Conduct in Human Research (NHMRC, 2018) Sect.\u00a02.3.10 as the retrospective quality assurance\/audit study analysed previously collected data and constituted negligible risk to participants who had already received standard-of-care.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent to participate"}}]}}