{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:26:52Z","timestamp":1782278812748,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"DOI":"10.1007\/s40620-024-02178-1","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T09:02:40Z","timestamp":1738227760000},"page":"643-653","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical presentation, outcomes and risk of relapses of lupus podocytopathy in a multicentre Italian cohort"],"prefix":"10.1093","volume":"38","author":[{"given":"Grazia Dea","family":"Bonelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savino","family":"Sciascia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Calatroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"L\u2019imperio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Fenoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza Maria","family":"Argolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Carrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Lepori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Reggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bortoluzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausta","family":"Catapano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariele","family":"Gatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Longhitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Garozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Trezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gerosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mosca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Roccatello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Alberto","family":"Sinico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7667-4541","authenticated-orcid":false,"given":"Gabriella","family":"Moroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"2178_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep256","author":"P Shea-Simonds","year":"2009","unstructured":"Shea-Simonds P, Cairns TD, Roufosse C, Cook T, Vyse TJ (2009) Lupus podocytopathy. Rheumatology. https:\/\/doi.org\/10.1093\/rheumatology\/kep256","journal-title":"Rheumatology"},{"issue":"2","key":"2178_CR2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1523-1755.2004.00443.x","volume":"65","author":"JJ Weening","year":"2004","unstructured":"Weening JJ et al (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 65(2):521\u2013530. https:\/\/doi.org\/10.1111\/j.1523-1755.2004.00443.x","journal-title":"Kidney Int"},{"issue":"4","key":"2178_CR3","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.kint.2017.11.023","volume":"93","author":"IM Bajema","year":"2018","unstructured":"Bajema IM, Wilhelmus S, Alpers CE, Bruijn JA, Colvin RB, Cook HT et al (2018) Revision of the international society of nephrology\/renal pathology society classification for lupus nephritis: clarification of definitions, and modified national institutes of health activity and chronicity indices. Kidney Int 93(4):789\u2013796. https:\/\/doi.org\/10.1016\/j.kint.2017.11.023","journal-title":"Kidney Int"},{"issue":"4","key":"2178_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.2215\/cjn.06720615","volume":"11","author":"W Hu","year":"2016","unstructured":"Hu W, Chen Y, Wang S, Chen H, Liu Z, Zeng C et al (2016) Clinical-morphological features and outcomes of lupus podocytopathy. Clin J Am Soc Nephrol 11(4):585\u2013592. https:\/\/doi.org\/10.2215\/cjn.06720615","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"2178_CR5","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000516790","volume":"1","author":"L Truong","year":"2021","unstructured":"Truong L, Seshan SV (2021) Lupus nephritis: the significant contribution of electron microscopy. Glomerular Dis 1(4):180\u2013204. https:\/\/doi.org\/10.1159\/000516790","journal-title":"Glomerular Dis"},{"issue":"5","key":"2178_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1053\/j.ackd.2019.08.011","volume":"26","author":"N Oliva-Damaso","year":"2019","unstructured":"Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS (2019) Lupus podocytopathy: an overview. Adv Chronic Kidney Dis 26(5):369\u2013375. https:\/\/doi.org\/10.1053\/j.ackd.2019.08.011","journal-title":"Adv Chronic Kidney Dis"},{"issue":"8","key":"2178_CR7","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nrneph.2017.85","volume":"13","author":"F Yu","year":"2017","unstructured":"Yu F, Haas M, Glassock R, Zhao MH (2017) Redefining lupus nephritis: clinical implications of pathophysiologic subtypes. Nat Rev Nephrol 13(8):483\u2013495. https:\/\/doi.org\/10.1038\/nrneph.2017.85","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"2178_CR8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/bor.0000000000000887","volume":"35","author":"R Bhargava","year":"2022","unstructured":"Bhargava R, Li H, Tsokos GC (2022) Pathogenesis of lupus nephritis: the contribution of immune and kidney resident cells. Curr Op Pisa Rheumatol 35(2):107\u2013116. https:\/\/doi.org\/10.1097\/bor.0000000000000887","journal-title":"Curr Op Pisa Rheumatol"},{"issue":"6","key":"2178_CR9","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.kint.2016.01.012","volume":"89","author":"M Nagata","year":"2016","unstructured":"Nagata M (2016) Podocyte injury and its consequences. Kidney Int 89(6):1221\u20131230. https:\/\/doi.org\/10.1016\/j.kint.2016.01.012","journal-title":"Kidney Int"},{"issue":"8","key":"2178_CR10","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1002\/art.40155","volume":"69","author":"R Fu","year":"2017","unstructured":"Fu R, Guo C, Wang S, Huang Y, Jin O, Hu H et al (2017) Podocyte activation of NLRP3 inflammasomes contributes to the development of proteinuria in lupus nephritis. Arthritis Rheumatol 69(8):1636\u20131646. https:\/\/doi.org\/10.1002\/art.40155","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"2178_CR11","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1093\/ndt\/gfad024","volume":"38","author":"C Ponticelli","year":"2023","unstructured":"Ponticelli C, Moroni G, Reggiani F (2023) Autophagy and podocytopathy. Nephrol Dial Transpl 38(9):1931\u20131939. https:\/\/doi.org\/10.1093\/ndt\/gfad024","journal-title":"Nephrol Dial Transpl"},{"key":"2178_CR12","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1136\/annrheumdis-2018-213028","volume":"12","author":"Y Qi","year":"2018","unstructured":"Qi Y, Zhou X, Cheng F, Hou P, Ren Y, Wang S et al (2018) Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-\u03b1 in lupus nephritis. Ann Rheum Dis 12:1799\u20131809. https:\/\/doi.org\/10.1136\/annrheumdis-2018-213028","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2178_CR13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.kint.2019.01.037","volume":"96","author":"C Kuppe","year":"2019","unstructured":"Kuppe C, Leuchtle K, Wagner A, Kabgani N, Saritas T, Puelles VG et al (2019) Novel parietal epithelial cell subpopulations contribute to focal segmental glomerulosclerosis and glomerular tip lesions. Kidney Int 96(1):80\u201393. https:\/\/doi.org\/10.1016\/j.kint.2019.01.037","journal-title":"Kidney Int"},{"key":"2178_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.832772","author":"Z Li","year":"2022","unstructured":"Li Z, Guo X, Quan X, Yang C, Liu Z, Su H et al (2022) The role of parietal epithelial cells in the pathogenesis of podocytopathy. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2022.832772","journal-title":"Front Physiol"},{"issue":"1","key":"2178_CR15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00441-017-2600-5","volume":"369","author":"L Miesen","year":"2017","unstructured":"Miesen L, Steenbergen E, Smeets B (2017) Parietal cells\u2014new perspectives in glomerular disease. Cell Tissue Res 369(1):237\u2013244. https:\/\/doi.org\/10.1007\/s00441-017-2600-5","journal-title":"Cell Tissue Res"},{"key":"2178_CR16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2314471sa","author":"FE Hengel","year":"2024","unstructured":"Hengel FE, Dehde S, Lass\u00e9 M, Zahner G, Seifert L, Schnarre A et al (2024) Autoantibodies targeting nephrin in podocytopathies. N Engl J Med. https:\/\/doi.org\/10.1056\/NEJMoa2314471sa","journal-title":"N Engl J Med"},{"issue":"4","key":"2178_CR17","doi-asserted-by":"publisher","first-page":"710","DOI":"10.2215\/CJN.08500815","volume":"11","author":"P Ravani","year":"2016","unstructured":"Ravani P, Bonanni A, Rossi R, Caridi G, Ghiggeri GM (2016) Anti-CD20 antibodies for idiopathic nephrotic syndrome in children. Clin J Am Soc Nephrol CJASN 11(4):710. https:\/\/doi.org\/10.2215\/CJN.08500815","journal-title":"Clin J Am Soc Nephrol CJASN"},{"issue":"8","key":"2178_CR18","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1001\/jamapediatrics.2018.1323","volume":"172","author":"B Basu","year":"2018","unstructured":"Basu B, Sander A, Roy B, Preussler S, Barua S, Mahapatra TKS et al (2018) Efficacy of rituximab vs tacrolimus in pediatric corticosteroid-dependent nephrotic syndrome. JAMA Pediatr 172(8):757. https:\/\/doi.org\/10.1001\/jamapediatrics.2018.1323","journal-title":"JAMA Pediatr"},{"issue":"48","key":"2178_CR19","doi-asserted-by":"publisher","first-page":"28799","DOI":"10.18632\/oncotarget.25612","volume":"9","author":"R Fenoglio","year":"2018","unstructured":"Fenoglio R, Sciascia S, Beltrame G, Mesiano P, Ferro M, Quattrocchio G et al (2018) Rituximab as a front-line therapy for adult-onset minimal change disease with nephrotic syndrome. Oncotarget 9(48):28799\u201328804. https:\/\/doi.org\/10.18632\/oncotarget.25612","journal-title":"Oncotarget"},{"issue":"10","key":"2178_CR20","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1177\/0961203315578766","volume":"24","author":"WX Hu","year":"2015","unstructured":"Hu WX, Chen YH, Bao H, Liu ZZ, Wang SF, Zhang HT (2015) Glucocorticoid with or without additional immunosuppressant therapy for patients with lupus podocytopathy: a retrospective single-center study. Lupus 24(10):1067\u20131075. https:\/\/doi.org\/10.1177\/0961203315578766","journal-title":"Lupus"},{"issue":"1","key":"2178_CR21","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1681\/asn.2004050350","volume":"16","author":"SW Kraft","year":"2005","unstructured":"Kraft SW, Schwartz MM, Korbet SM, Lewis EJ (2005) Glomerular podocytopathy in patients with systemic lupus erythematosus. J Am Soc Nephrol 16(1):175\u2013179. https:\/\/doi.org\/10.1681\/asn.2004050350","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"2178_CR22","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1177\/0961203317720526","volume":"27","author":"SF Wang","year":"2017","unstructured":"Wang SF, Chen YH, Chen DQ, Liu ZZ, Xu F, Zeng CH et al (2017) Mesangial proliferative lupus nephritis with podocytopathy: a special entity of lupus nephritis. Lupus 27(2):303\u2013311. https:\/\/doi.org\/10.1177\/0961203317720526","journal-title":"Lupus"},{"issue":"9","key":"2178_CR23","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC (1997) Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725\u20131735. https:\/\/doi.org\/10.1002\/art.1780400928","journal-title":"Arthritis Rheum"},{"issue":"6","key":"2178_CR24","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1053\/ajkd.2002.36875","volume":"40","author":"A Hertig","year":"2002","unstructured":"Hertig A, Droz D, Lesavre P, Gr\u00fcnfeld JP, Rieu P (2002) SLE and idiopathic nephrotic syndrome: coincidence or not? Am J Kidney Dis 40(6):1179\u20131184. https:\/\/doi.org\/10.1053\/ajkd.2002.36875","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"2178_CR25","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.kint.2020.02.010","volume":"97","author":"AS Levey","year":"2020","unstructured":"Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Hoorn EJ, Ingelfinger JR et al (2020) Nomenclature for kidney function and disease: report of a kidney disease: improving global outcomes (KDIGO) consensus conference. Kidney Int 97(6):1117\u20131129. https:\/\/doi.org\/10.1016\/j.kint.2020.02.010","journal-title":"Kidney Int"},{"issue":"02","key":"2178_CR26","doi-asserted-by":"publisher","first-page":"120","DOI":"10.5414\/cnp57120","volume":"57","author":"GK Dube","year":"2002","unstructured":"Dube GK, Markowitz GS, Radhakrishnan J, Appel GB, D\u2019Agati VD (2002) Minimal change disease in systemic lupus erythematosus. Clin Nephrol 57(02):120\u2013126. https:\/\/doi.org\/10.5414\/cnp57120","journal-title":"Clin Nephrol"},{"issue":"5993","key":"2178_CR27","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1193032","volume":"329","author":"G Genovese","year":"2010","unstructured":"Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI et al (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329(5993):841\u2013845. https:\/\/doi.org\/10.1126\/science.1193032","journal-title":"Science"},{"issue":"2","key":"2178_CR28","doi-asserted-by":"publisher","first-page":"294","DOI":"10.2215\/cjn.15161219","volume":"16","author":"DJ Friedman","year":"2020","unstructured":"Friedman DJ, Pollak MR (2020) APOL1 nephropathy: from genetics to clinical applications. Clin J Am Soc Nephrol 16(2):294\u2013303. https:\/\/doi.org\/10.2215\/cjn.15161219","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"2178_CR29","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.autrev.2017.11.003","volume":"17","author":"G Moroni","year":"2018","unstructured":"Moroni G, Gatto M, Raffiotta F, Binda V, Frangou E, Lightstone L et al (2018) Can we withdraw immunosuppressants in patients with lupus nephritis in remission? An expert debate. Autoimmun Rev 17(1):11\u201318. https:\/\/doi.org\/10.1016\/j.autrev.2017.11.003","journal-title":"Autoimmun Rev"},{"key":"2178_CR30","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s40620-017-0463-1","volume":"31","author":"C Duqun","year":"2017","unstructured":"Duqun C, Weixin H (2017) Lupus podocytopathy: a distinct entity of lupus nephritis. J Nephrol 31:629\u2013634. https:\/\/doi.org\/10.1007\/s40620-017-0463-1","journal-title":"J Nephrol"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-024-02178-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-024-02178-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-024-02178-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:54:12Z","timestamp":1777564452000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/38\/2\/643\/8307218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["2178"],"URL":"https:\/\/doi.org\/10.1007\/s40620-024-02178-1","relation":{},"ISSN":["1724-6059"],"issn-type":[{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"12 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no financial or non-financial interests that are directly or indirectly related to the work submitted for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee of IRCCS Humanitas Rozzano, Milano, Italy (protocol code NEF0032023)\u00a0no animal models were included in our study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients provided written informed consent for the scientific use of their data that was anonymized.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent to participate"}}]}}