{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:54:14Z","timestamp":1777870454096,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2024-00403375"],"award-info":[{"award-number":["RS-2024-00403375"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2024-00345867"],"award-info":[{"award-number":["RS-2024-00345867"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean Association of Internal Medicine Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"DOI":"10.1007\/s40620-025-02233-5","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T03:57:58Z","timestamp":1741665478000},"page":"1819-1829","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of conserved gene expression changes across common glomerular diseases by spatial transcriptomics"],"prefix":"10.1093","volume":"38","author":[{"given":"Jeong Min","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minji","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaeik","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunah","family":"Ku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha Yeon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hun","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaerim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soojin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Seok","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwon-Wook","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hee","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Chul","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Je","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of KORNERSTONE investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"2233_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00816-y","author":"HJ Anders","year":"2023","unstructured":"Anders HJ, Kitching AR, Leung N, Romagnani P (2023) Glomerulonephritis: immunopathogenesis and immunotherapy. Nat Rev Immunol. https:\/\/doi.org\/10.1038\/s41577-022-00816-y","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2233_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.23876\/j.krcp.20.202","volume":"40","author":"YA Hong","year":"2021","unstructured":"Hong YA et al (2021) Trends in epidemiologic characteristics of end-stage renal disease from 2019 Korean Renal Data System (KORDS). Kidney Res Clin Pract 40(1):52\u201361. https:\/\/doi.org\/10.23876\/j.krcp.20.202","journal-title":"Kidney Res Clin Pract"},{"issue":"4","key":"2233_CR3","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.kint.2016.04.026","volume":"90","author":"JB Wetmore","year":"2016","unstructured":"Wetmore JB, Guo H, Liu J, Collins AJ, Gilbertson DT (2016) The incidence, prevalence, and outcomes of glomerulonephritis derived from a large retrospective analysis. Kidney Int 90(4):853\u2013860. https:\/\/doi.org\/10.1016\/j.kint.2016.04.026","journal-title":"Kidney Int"},{"issue":"25","key":"2233_CR4","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1056\/NEJMra1106556","volume":"365","author":"VD D'Agati","year":"2011","unstructured":"D\u2019Agati VD, Kaskel FJ, Falk RJ (2011) Focal segmental glomerulosclerosis. N Engl J Med 365(25):2398\u20132411. https:\/\/doi.org\/10.1056\/NEJMra1106556","journal-title":"N Engl J Med"},{"issue":"6","key":"2233_CR5","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.kint.2016.01.012","volume":"89","author":"M Nagata","year":"2016","unstructured":"Nagata M (2016) Podocyte injury and its consequences. Kidney Int 89(6):1221\u20131230. https:\/\/doi.org\/10.1016\/j.kint.2016.01.012","journal-title":"Kidney Int"},{"issue":"5","key":"2233_CR6","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/s41592-022-01409-2","volume":"19","author":"L Moses","year":"2022","unstructured":"Moses L, Pachter L (2022) Museum of spatial transcriptomics. Nat Methods 19(5):534\u2013546. https:\/\/doi.org\/10.1038\/s41592-022-01409-2","journal-title":"Nat Methods"},{"issue":"2","key":"2233_CR7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1046\/j.1523-1755.2002.00164.x","volume":"61","author":"Q Al-Awqati","year":"2002","unstructured":"Al-Awqati Q, Oliver JA (2002) Stem cells in the kidney. Kidney Int 61(2):387\u2013395. https:\/\/doi.org\/10.1046\/j.1523-1755.2002.00164.x","journal-title":"Kidney Int"},{"issue":"1","key":"2233_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.kint.2021.09.004","volume":"101","author":"F Salem","year":"2022","unstructured":"Salem F et al (2022) The spatially resolved transcriptional profile of acute T cell-mediated rejection in a kidney allograft. Kidney Int 101(1):131\u2013136. https:\/\/doi.org\/10.1016\/j.kint.2021.09.004","journal-title":"Kidney Int"},{"issue":"5","key":"2233_CR9","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.kint.2022.01.033","volume":"101","author":"KD Smith","year":"2022","unstructured":"Smith KD, Prince DK, Henriksen KJ, Nicosia RF, Alpers CE, Akilesh S (2022) Digital spatial profiling of collapsing glomerulopathy. Kidney Int 101(5):1017\u20131026. https:\/\/doi.org\/10.1016\/j.kint.2022.01.033","journal-title":"Kidney Int"},{"key":"2233_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43458-x","author":"A Janesick","year":"2023","unstructured":"Janesick A et al (2023) High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-023-43458-x","journal-title":"Nat Commun"},{"issue":"3","key":"2233_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1097\/moh.0000000000000239","volume":"23","author":"P Lertkiatmongkol","year":"2016","unstructured":"Lertkiatmongkol P, Liao D, Mei H, Hu Y, Newman PJ (2016) Endothelial functions of platelet\/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol 23(3):253\u2013259. https:\/\/doi.org\/10.1097\/moh.0000000000000239","journal-title":"Curr Opin Hematol"},{"key":"2233_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/2050-7771-2-21","volume":"2","author":"Y Kandasamy","year":"2014","unstructured":"Kandasamy Y, Smith R, Lumbers ER, Rudd D (2014) Nephrin\u2014a biomarker of early glomerular injury. Biomark Res 2:21. https:\/\/doi.org\/10.1186\/2050-7771-2-21","journal-title":"Biomark Res"},{"key":"2233_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22331-9","author":"B He","year":"2021","unstructured":"He B et al (2021) Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-021-22331-9","journal-title":"Nat Commun"},{"issue":"2","key":"2233_CR14","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1046\/j.1523-1755.2003.00097.x","volume":"64","author":"J Lahdenper\u00e4","year":"2003","unstructured":"Lahdenper\u00e4 J et al (2003) Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases. Kidney Int 64(2):404\u2013413. https:\/\/doi.org\/10.1046\/j.1523-1755.2003.00097.x","journal-title":"Kidney Int"},{"issue":"45","key":"2233_CR15","doi-asserted-by":"publisher","first-page":"41543","DOI":"10.1074\/jbc.C100452200","volume":"276","author":"TB Huber","year":"2001","unstructured":"Huber TB, Kottgen M, Schilling B, Walz G, Benzing T (2001) Interaction with podocin facilitates nephrin signaling. J Biol Chem 276(45):41543\u201341546. https:\/\/doi.org\/10.1074\/jbc.C100452200","journal-title":"J Biol Chem"},{"issue":"2","key":"2233_CR16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s10911-020-09448-1","volume":"25","author":"R Canzoneri","year":"2020","unstructured":"Canzoneri R et al (2020) Identification of an AP1-ZFP36 regulatory network associated with breast cancer prognosis. J Mammary Gland Biol Neoplasia 25(2):163\u2013172. https:\/\/doi.org\/10.1007\/s10911-020-09448-1","journal-title":"J Mammary Gland Biol Neoplasia"},{"issue":"2","key":"2233_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300453","volume":"8","author":"C Tang","year":"2024","unstructured":"Tang C et al (2024) Identification and validation of glomeruli cellular senescence-related genes in diabetic nephropathy by multiomics. Adv Biol (Weinh) 8(2):e2300453. https:\/\/doi.org\/10.1002\/adbi.202300453","journal-title":"Adv Biol (Weinh)"},{"issue":"7970","key":"2233_CR18","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41586-023-05769-3","volume":"619","author":"BB Lake","year":"2023","unstructured":"Lake BB et al (2023) An atlas of healthy and injured cell states and niches in the human kidney. Nature 619(7970):585\u2013594. https:\/\/doi.org\/10.1038\/s41586-023-05769-3","journal-title":"Nature"},{"issue":"1","key":"2233_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41592-020-01033-y","volume":"18","author":"V Marx","year":"2021","unstructured":"Marx V (2021) Method of the year: spatially resolved transcriptomics. Nat Methods 18(1):9\u201314. https:\/\/doi.org\/10.1038\/s41592-020-01033-y","journal-title":"Nat Methods"},{"issue":"2","key":"2233_CR20","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1681\/asn.2021081150","volume":"33","author":"EE Dixon","year":"2022","unstructured":"Dixon EE, Wu H, Muto Y, Wilson PC, Humphreys BD (2022) Spatially resolved transcriptomic analysis of acute kidney injury in a female murine model. J Am Soc Nephrol 33(2):279\u2013289. https:\/\/doi.org\/10.1681\/asn.2021081150","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"2233_CR21","doi-asserted-by":"publisher","first-page":"4684","DOI":"10.1111\/jcmm.16407","volume":"25","author":"Z Chen","year":"2021","unstructured":"Chen Z et al (2021) A single-cell survey of the human glomerulonephritis. J Cell Mol Med 25(10):4684\u20134695. https:\/\/doi.org\/10.1111\/jcmm.16407","journal-title":"J Cell Mol Med"},{"issue":"10","key":"2233_CR22","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1681\/asn.2020020220","volume":"31","author":"JJ Chung","year":"2020","unstructured":"Chung JJ et al (2020) Single-cell transcriptome profiling of the kidney glomerulus identifies key cell types and reactions to injury. J Am Soc Nephrol 31(10):2341\u20132354. https:\/\/doi.org\/10.1681\/asn.2020020220","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"2233_CR23","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1681\/asn.2021020157","volume":"32","author":"D Deleersnijder","year":"2021","unstructured":"Deleersnijder D et al (2021) Current methodological challenges of single-cell and single-nucleus RNA-sequencing in glomerular diseases. J Am Soc Nephrol 32(8):1838\u20131852. https:\/\/doi.org\/10.1681\/asn.2021020157","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"2233_CR24","doi-asserted-by":"publisher","first-page":"F809","DOI":"10.1152\/ajprenal.00037.2020","volume":"319","author":"S Park","year":"2020","unstructured":"Park S et al (2020) RNA-Seq profiling of microdissected glomeruli identifies potential biomarkers for human IgA nephropathy. Am J Physiol Renal Physiol 319(5):F809-f821. https:\/\/doi.org\/10.1152\/ajprenal.00037.2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"2233_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2017.10.003","author":"F Persson","year":"2018","unstructured":"Persson F, Rossing P (2018) Diagnosis of diabetic kidney disease: state of the art and future perspective. Kidney Int Suppl. https:\/\/doi.org\/10.1016\/j.kisu.2017.10.003","journal-title":"Kidney Int Suppl"},{"issue":"5","key":"2233_CR26","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.kint.2017.02.003","volume":"91","author":"H Trimarchi","year":"2017","unstructured":"Trimarchi H et al (2017) Oxford classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group. Kidney Int 91(5):1014\u20131021. https:\/\/doi.org\/10.1016\/j.kint.2017.02.003","journal-title":"Kidney Int"},{"issue":"3","key":"2233_CR27","doi-asserted-by":"publisher","first-page":"445","DOI":"10.2215\/cjn.03531006","volume":"2","author":"M Waldman","year":"2007","unstructured":"Waldman M et al (2007) Adult minimal-change disease: clinical characteristics, treatment, and outcomes. Clin J Am Soc Nephrol 2(3):445\u2013453. https:\/\/doi.org\/10.2215\/cjn.03531006","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"2233_CR28","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1681\/asn.2008070694","volume":"20","author":"B Schermer","year":"2009","unstructured":"Schermer B, Benzing T (2009) Lipid-protein interactions along the slit diaphragm of podocytes. J Am Soc Nephrol 20(3):473\u2013478. https:\/\/doi.org\/10.1681\/asn.2008070694","journal-title":"J Am Soc Nephrol"},{"issue":"15","key":"2233_CR29","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1056\/NEJMra1808786","volume":"384","author":"T Benzing","year":"2021","unstructured":"Benzing T, Salant D (2021) Insights into glomerular filtration and albuminuria. N Engl J Med 384(15):1437\u20131446. https:\/\/doi.org\/10.1056\/NEJMra1808786","journal-title":"N Engl J Med"},{"issue":"6","key":"2233_CR30","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrc818","volume":"2","author":"PK Vogt","year":"2002","unstructured":"Vogt PK (2002) Fortuitous convergences: the beginnings of JUN. Nat Rev Cancer 2(6):465\u2013469. https:\/\/doi.org\/10.1038\/nrc818","journal-title":"Nat Rev Cancer"},{"issue":"19","key":"2233_CR31","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1038\/sj.onc.1204239","volume":"20","author":"H van Dam","year":"2001","unstructured":"van Dam H, Castellazzi M (2001) Distinct roles of Jun\u202f: Fos and Jun\u202f: ATF dimers in oncogenesis. Oncogene 20(19):2453\u201364. https:\/\/doi.org\/10.1038\/sj.onc.1204239","journal-title":"Oncogene"},{"issue":"16","key":"2233_CR32","doi-asserted-by":"publisher","first-page":"11706","DOI":"10.1074\/jbc.275.16.11706","volume":"275","author":"M Yoshizumi","year":"2000","unstructured":"Yoshizumi M, Abe J, Haendeler J, Huang Q, Berk BC (2000) Src and Cas mediate JNK activation but not ERK1\/2 and p38 kinases by reactive oxygen species. J Biol Chem 275(16):11706\u201311712. https:\/\/doi.org\/10.1074\/jbc.275.16.11706","journal-title":"J Biol Chem"},{"issue":"9","key":"2233_CR33","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1096\/fj.00-0787fje","volume":"15","author":"C Bezombes","year":"2001","unstructured":"Bezombes C et al (2001) Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C. Faseb J 15(9):1583\u20131585. https:\/\/doi.org\/10.1096\/fj.00-0787fje","journal-title":"Faseb j"},{"issue":"7","key":"2233_CR34","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1091\/mbc.12.7.2171","volume":"12","author":"JA Fresno Vara","year":"2001","unstructured":"Fresno Vara JA, C\u00e1ceres MA, Silva A, Mart\u00edn-P\u00e9rez J (2001) Src family kinases are required for prolactin induction of cell proliferation. Mol Biol Cell 12(7):2171\u20132183. https:\/\/doi.org\/10.1091\/mbc.12.7.2171","journal-title":"Mol Biol Cell"},{"issue":"6","key":"2233_CR35","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1128\/mcb.26.6.2399-2407.2006","volume":"26","author":"E Hitti","year":"2006","unstructured":"Hitti E et al (2006) Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine\/uridine-rich element. Mol Cell Biol 26(6):2399\u20132407. https:\/\/doi.org\/10.1128\/mcb.26.6.2399-2407.2006","journal-title":"Mol Cell Biol"},{"issue":"24","key":"2233_CR36","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1038\/sj.onc.1210137","volume":"26","author":"MM Portal","year":"2007","unstructured":"Portal MM, Ferrero GO, Caputto BL (2007) N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos\/ER association and c-Fos-dependent phospholipid synthesis activation. Oncogene 26(24):3551\u20133558. https:\/\/doi.org\/10.1038\/sj.onc.1210137","journal-title":"Oncogene"},{"issue":"45","key":"2233_CR37","doi-asserted-by":"publisher","first-page":"31163","DOI":"10.1074\/jbc.M709257200","volume":"283","author":"PM Crespo","year":"2008","unstructured":"Crespo PM, Silvestre DC, Gil GA, Maccioni HJ, Daniotti JL, Caputto BL (2008) c-Fos activates glucosylceramide synthase and glycolipid synthesis in PC12 cells. J Biol Chem 283(45):31163\u201331171. https:\/\/doi.org\/10.1074\/jbc.M709257200","journal-title":"J Biol Chem"},{"issue":"24","key":"2233_CR38","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1093\/hmg\/ddg360","volume":"12","author":"TB Huber","year":"2003","unstructured":"Huber TB et al (2003) Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet 12(24):3397\u20133405. https:\/\/doi.org\/10.1093\/hmg\/ddg360","journal-title":"Hum Mol Genet"},{"issue":"6633","key":"2233_CR39","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/42408","volume":"387","author":"K Simons","year":"1997","unstructured":"Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387(6633):569\u2013572. https:\/\/doi.org\/10.1038\/42408","journal-title":"Nature"},{"key":"2233_CR40","doi-asserted-by":"publisher","first-page":"840890","DOI":"10.3389\/fphys.2022.840890","volume":"13","author":"X Zhou","year":"2022","unstructured":"Zhou X, Wang N, Zhang Y, Yu P (2022) Expression of CCL2, FOS, and JUN May Help to Distinguish Patients With IgA Nephropathy From Healthy Controls. Front Physiol 13:840890. https:\/\/doi.org\/10.3389\/fphys.2022.840890","journal-title":"Front Physiol"},{"issue":"7","key":"2233_CR41","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1093\/ndt\/13.7.1668","volume":"13","author":"MP Rastaldi","year":"1998","unstructured":"Rastaldi MP et al (1998) Transforming growth factor-beta, endothelin-1, and c-fos expression in necrotizing\/crescentic IgA glomerulonephritis. Nephrol Dial Transplant 13(7):1668\u20131674. https:\/\/doi.org\/10.1093\/ndt\/13.7.1668","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"2233_CR42","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/path.2228","volume":"213","author":"MH De Borst","year":"2007","unstructured":"De Borst MH et al (2007) Glomerular and tubular induction of the transcription factor c-Jun in human renal disease. J Pathol 213(2):219\u2013228. https:\/\/doi.org\/10.1002\/path.2228","journal-title":"J Pathol"},{"issue":"9","key":"2233_CR43","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1681\/asn.2004110913","volume":"16","author":"NH Le","year":"2005","unstructured":"Le NH et al (2005) Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease. J Am Soc Nephrol 16(9):2724\u20132731. https:\/\/doi.org\/10.1681\/asn.2004110913","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"2233_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2004.08.047","volume":"323","author":"SJ Park","year":"2004","unstructured":"Park SJ, Jeong KS (2004) Cell-type-specific activation of mitogen-activated protein kinases in PAN-induced progressive renal disease in rats. Biochem Biophys Res Commun 323(1):1\u20138. https:\/\/doi.org\/10.1016\/j.bbrc.2004.08.047","journal-title":"Biochem Biophys Res Commun"},{"issue":"16","key":"2233_CR45","doi-asserted-by":"publisher","first-page":"12903","DOI":"10.1074\/jbc.M010626200","volume":"276","author":"B Malik","year":"2001","unstructured":"Malik B et al (2001) Enac degradation in A6 cells by the ubiquitin-proteosome proteolytic pathway. J Biol Chem 276(16):12903\u201312910. https:\/\/doi.org\/10.1074\/jbc.M010626200","journal-title":"J Biol Chem"},{"issue":"Pt 3","key":"2233_CR46","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1042\/0264-6021:3610481","volume":"361","author":"JS Lott","year":"2002","unstructured":"Lott JS, Coddington-Lawson SJ, Teesdale-Spittle PH, McDonald FJ (2002) A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel. Biochem J 361(Pt 3):481\u2013488. https:\/\/doi.org\/10.1042\/0264-6021:3610481","journal-title":"Biochem J"},{"issue":"3","key":"2233_CR47","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/path.2446","volume":"217","author":"C Meyer-Schwesinger","year":"2009","unstructured":"Meyer-Schwesinger C et al (2009) A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies. J Pathol 217(3):452\u2013464. https:\/\/doi.org\/10.1002\/path.2446","journal-title":"J Pathol"},{"issue":"5","key":"2233_CR48","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.ajpath.2011.01.017","volume":"178","author":"C Meyer-Schwesinger","year":"2011","unstructured":"Meyer-Schwesinger C et al (2011) Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy. Am J Pathol 178(5):2044\u20132057. https:\/\/doi.org\/10.1016\/j.ajpath.2011.01.017","journal-title":"Am J Pathol"},{"issue":"5","key":"2233_CR49","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/ki.2008.579","volume":"75","author":"R Coppo","year":"2009","unstructured":"Coppo R et al (2009) Upregulation of the immunoproteasome in peripheral blood mononuclear cells of patients with IgA nephropathy. Kidney Int 75(5):536\u2013541. https:\/\/doi.org\/10.1038\/ki.2008.579","journal-title":"Kidney Int"},{"issue":"11","key":"2233_CR50","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1681\/asn.2013050522","volume":"25","author":"M Beeken","year":"2014","unstructured":"Beeken M et al (2014) Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases. J Am Soc Nephrol 25(11):2511\u20132525. https:\/\/doi.org\/10.1681\/asn.2013050522","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-025-02233-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-025-02233-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-025-02233-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:59:39Z","timestamp":1777564779000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/38\/7\/1819\/8461058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["2233"],"URL":"https:\/\/doi.org\/10.1007\/s40620-025-02233-5","relation":{},"ISSN":["1724-6059"],"issn-type":[{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,11]]},"assertion":[{"value":"18 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors have disclosures to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board of Seoul National University Hospital (IRB No. 2208-137-1353). The study was performed in accordance with the Declaration of Helsinki guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Remnant formalin-fixed paraffin-embedded tissue samples from patients with five glomerular diseases were collected in the study hospital. Informed consent was obtained from most of the study participants before collecting any biospecimens or clinical information. For a few patients who were biopsied in the remote past periods, the use of the remnant tissue was approved and requirement for the informed consent was waived by the Institutional Review Board.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}