{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:33:10Z","timestamp":1779129190465,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2011E3300300"],"award-info":[{"award-number":["2011E3300300"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2012E3301100"],"award-info":[{"award-number":["2012E3301100"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2013E3301600"],"award-info":[{"award-number":["2013E3301600"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2013E3301601"],"award-info":[{"award-number":["2013E3301601"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2013E3301602"],"award-info":[{"award-number":["2013E3301602"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2016E3300200"],"award-info":[{"award-number":["2016E3300200"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2016E3300201"],"award-info":[{"award-number":["2016E3300201"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2016E3300202"],"award-info":[{"award-number":["2016E3300202"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2019E320100"],"award-info":[{"award-number":["2019E320100"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2019E320101"],"award-info":[{"award-number":["2019E320101"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2019E320102"],"award-info":[{"award-number":["2019E320102"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2022-11-007"],"award-info":[{"award-number":["2022-11-007"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health","award":["2025E110100"],"award-info":[{"award-number":["2025E110100"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"DOI":"10.1007\/s40620-025-02345-y","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T16:27:34Z","timestamp":1753720054000},"page":"2375-2387","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of accelerometer-measured physical activity with adverse cardiovascular outcomes in individuals with or without chronic kidney diseases: the UK biobank study"],"prefix":"10.1093","volume":"38","author":[{"given":"Byounghwi","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye Eun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan-Young","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hoon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Byung","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga Young","family":"Heo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Tak","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Hyun","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Wook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue Kyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Wan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suah","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kook Hwan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7923-5635","authenticated-orcid":false,"given":"Seung Hyeok","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Korean cohort study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD) Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"issue":"1","key":"2345_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","volume":"12","author":"CP Kovesdy","year":"2022","unstructured":"Kovesdy CP (2022) Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl 12(1):7\u201311. https:\/\/doi.org\/10.1016\/j.kisu.2021.11.003","journal-title":"Kidney Int Suppl"},{"issue":"9889","key":"2345_CR2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/s0140-6736(13)60595-4","volume":"382","author":"RT Gansevoort","year":"2013","unstructured":"Gansevoort RT, Correa-Rotter R, Hemmelgarn BR et al (2013) Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention. Lancet 382(9889):339\u2013352. https:\/\/doi.org\/10.1016\/s0140-6736(13)60595-4","journal-title":"Lancet"},{"issue":"3","key":"2345_CR3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.kint.2020.11.003","volume":"99","author":"AK Cheung","year":"2021","unstructured":"Cheung AK, Chang TI, Cushman WC et al (2021) KDIGO 2021 Clinical practice guideline for the management of blood pressure in chronic kidney disease. Kidney Int 99(3):S1\u2013S87. https:\/\/doi.org\/10.1016\/j.kint.2020.11.003","journal-title":"Kidney Int"},{"issue":"6","key":"2345_CR4","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.2215\/CJN.02920608","volume":"3","author":"R Agarwal","year":"2008","unstructured":"Agarwal R, Light RP (2008) Physical activity and hemodynamic reactivity in chronic kidney disease. Clin J Am Soc Nephrol 3(6):1660\u20131668. https:\/\/doi.org\/10.2215\/CJN.02920608","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"2345_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1136\/bjsm.37.3.197","volume":"37","author":"RJ Shephard","year":"2003","unstructured":"Shephard RJ (2003) Limits to the measurement of habitual physical activity by questionnaires. Br J Sports Med 37(3):197\u2013206. https:\/\/doi.org\/10.1136\/bjsm.37.3.197","journal-title":"Br J Sports Med"},{"issue":"4","key":"2345_CR6","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1249\/MSS.0000000000000468","volume":"47","author":"DR Bassett","year":"2015","unstructured":"Bassett DR, Troiano RP, McClain JJ et al (2015) Accelerometer-based physical activity: total volume per day and standardized measures. Med Sci Sports Exerc 47(4):833\u2013838. https:\/\/doi.org\/10.1249\/MSS.0000000000000468","journal-title":"Med Sci Sports Exerc"},{"issue":"12","key":"2345_CR7","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1161\/CIRCULATIONAHA.122.059663","volume":"146","author":"FK Ho","year":"2022","unstructured":"Ho FK, Zhou Z, Petermann-Rocha F et al (2022) Association between device-measured physical activity and incident heart failure: a prospective cohort study of 94 739 UK biobank participants. Circulation 146(12):883\u2013891. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.122.059663","journal-title":"Circulation"},{"issue":"46","key":"2345_CR8","doi-asserted-by":"publisher","first-page":"4789","DOI":"10.1093\/eurheartj\/ehac613","volume":"43","author":"PC Dempsey","year":"2022","unstructured":"Dempsey PC, Rowlands AV, Strain T et al (2022) Physical activity volume, intensity, and incident cardiovascular disease. Eur Heart J 43(46):4789\u20134800. https:\/\/doi.org\/10.1093\/eurheartj\/ehac613","journal-title":"Eur Heart J"},{"issue":"2","key":"2345_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169649","volume":"12","author":"A Doherty","year":"2017","unstructured":"Doherty A, Jackson D, Hammerla N et al (2017) Large scale population assessment of physical activity using wrist worn accelerometers: the UK biobank study. PLoS ONE 12(2):e0169649. https:\/\/doi.org\/10.1371\/journal.pone.0169649","journal-title":"PLoS ONE"},{"key":"2345_CR10","doi-asserted-by":"publisher","first-page":"102323","DOI":"10.1016\/j.eclinm.2023.102323","volume":"66","author":"X Zhang","year":"2023","unstructured":"Zhang X, Liu Y-M, Lei F et al (2023) Association between questionnaire-based and accelerometer-based physical activity and the incidence of chronic kidney disease using data from UK Biobank: a prospective cohort study. eClinicalMedicine 66:102323. https:\/\/doi.org\/10.1016\/j.eclinm.2023.102323","journal-title":"eClinicalMedicine"},{"issue":"9838","key":"2345_CR11","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0140-6736(12)61031-9","volume":"380","author":"IM Lee","year":"2012","unstructured":"Lee IM, Shiroma EJ, Lobelo F et al (2012) Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 380(9838):219\u2013229. https:\/\/doi.org\/10.1016\/S0140-6736(12)61031-9","journal-title":"Lancet"},{"issue":"1","key":"2345_CR12","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1038\/s41467-018-07743-4","volume":"9","author":"A Doherty","year":"2018","unstructured":"Doherty A, Smith-Byrne K, Ferreira T et al (2018) GWAS identifies 14 loci for device-measured physical activity and sleep duration. Nat Commun 9(1):5257. https:\/\/doi.org\/10.1038\/s41467-018-07743-4","journal-title":"Nat Commun"},{"issue":"18","key":"2345_CR13","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1136\/bjsports-2021-104050","volume":"56","author":"R Walmsley","year":"2022","unstructured":"Walmsley R, Chan S, Smith-Byrne K et al (2022) Reallocation of time between device-measured movement behaviours and risk of incident cardiovascular disease. Br J Sports Med 56(18):1008\u20131017. https:\/\/doi.org\/10.1136\/bjsports-2021-104050","journal-title":"Br J Sports Med"},{"issue":"4","key":"2345_CR14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.23876\/j.krcp.22.158","volume":"42","author":"H Kim","year":"2023","unstructured":"Kim H, Hyun YY, Yun H-R et al (2023) Predictive performance of the new race-free chronic kidney disease epidemiology collaboration equations for kidney outcome in Korean patients with chronic kidney disease. Kidney Res Clin Pract 42(4):501\u2013511. https:\/\/doi.org\/10.23876\/j.krcp.22.158","journal-title":"Kidney Res Clin Pract"},{"issue":"4","key":"2345_CR15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3961\/jpmph.22.031","volume":"55","author":"KH Oh","year":"2022","unstructured":"Oh KH, Park SK, Kim J et al (2022) The KoreaN Cohort study for outcomes in patients with chronic kidney disease (KNOW-CKD): a Korean chronic kidney disease cohort. J Prev Med Public Health 55(4):313\u2013320. https:\/\/doi.org\/10.3961\/jpmph.22.031","journal-title":"J Prev Med Public Health"},{"issue":"10075","key":"2345_CR16","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/s0140-6736(16)32064-5","volume":"389","author":"AC Webster","year":"2017","unstructured":"Webster AC, Nagler EV, Morton RL et al (2017) Chronic kidney disease. Lancet 389(10075):1238\u20131252. https:\/\/doi.org\/10.1016\/s0140-6736(16)32064-5","journal-title":"Lancet"},{"issue":"10","key":"2345_CR17","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1681\/asn.2014070714","volume":"26","author":"S Thompson","year":"2015","unstructured":"Thompson S, James M, Wiebe N et al (2015) Cause of death in patients with reduced kidney function. J Am Soc Nephrol 26(10):2504\u20132511. https:\/\/doi.org\/10.1681\/asn.2014070714","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"2345_CR18","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/nrneph.2016.187","volume":"13","author":"DM Zelle","year":"2017","unstructured":"Zelle DM, Klaassen G, van Adrichem E et al (2017) Physical inactivity: a risk factor and target for intervention in renal care. Nat Rev Nephrol 13(3):152\u2013168. https:\/\/doi.org\/10.1038\/nrneph.2016.187","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"2345_CR19","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/j.1532-5415.2006.00727.x","volume":"54","author":"LF Fried","year":"2006","unstructured":"Fried LF, Lee JS, Shlipak M et al (2006) Chronic kidney disease and functional limitation in older people: health, aging and body composition study. J Am Geriatr Soc 54(5):750\u2013756. https:\/\/doi.org\/10.1111\/j.1532-5415.2006.00727.x","journal-title":"J Am Geriatr Soc"},{"issue":"11","key":"2345_CR20","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1161\/CIRCULATIONAHA.120.050686","volume":"143","author":"J Jankowski","year":"2021","unstructured":"Jankowski J, Floege J, Fliser D et al (2021) Cardiovascular disease in chronic kidney disease. Circulation 143(11):1157\u20131172. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.050686","journal-title":"Circulation"},{"issue":"6","key":"2345_CR21","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1681\/asn.2012080870","volume":"24","author":"M Tonelli","year":"2013","unstructured":"Tonelli M, Muntner P, Lloyd A et al (2013) Association between LDL-C and risk of myocardial infarction in CKD. J Am Soc Nephrol 24(6):979\u2013986. https:\/\/doi.org\/10.1681\/asn.2012080870","journal-title":"J Am Soc Nephrol"},{"issue":"19","key":"2345_CR22","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.122.027516","volume":"11","author":"CL Yen","year":"2022","unstructured":"Yen CL, Fan PC, Lee CC et al (2022) Association of low-density lipoprotein cholesterol levels during statin treatment with cardiovascular and renal outcomes in patients with moderate chronic kidney disease. J Am Heart Assoc 11(19):e027516. https:\/\/doi.org\/10.1161\/jaha.122.027516","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"2345_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.atherosclerosis.2012.01.043","volume":"223","author":"WE Moody","year":"2012","unstructured":"Moody WE, Edwards NC, Madhani M et al (2012) Endothelial dysfunction and cardiovascular disease in early-stage chronic kidney disease: Cause or association? Atherosclerosis 223(1):86\u201394. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.01.043","journal-title":"Atherosclerosis"},{"issue":"2","key":"2345_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1136\/heart.83.2.205","volume":"83","author":"J Thambyrajah","year":"2000","unstructured":"Thambyrajah J, Landray M, McGlynn F et al (2000) Abnormalities of endothelial function in patients with predialysis renal failure. Heart 83(2):205\u2013209","journal-title":"Heart"},{"issue":"12","key":"2345_CR25","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/ijo.2012.7","volume":"36","author":"SD Navaneethan","year":"2012","unstructured":"Navaneethan SD, Kirwan JP, Arrigain S et al (2012) Overweight, obesity and intentional weight loss in chronic kidney disease: NHANES 1999\u20132006. Int J Obes (Lond) 36(12):1585\u20131590. https:\/\/doi.org\/10.1038\/ijo.2012.7","journal-title":"Int J Obes (Lond)"},{"issue":"7","key":"2345_CR26","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.2215\/CJN.08410814","volume":"10","author":"S Beddhu","year":"2015","unstructured":"Beddhu S, Wei G, Marcus RL et al (2015) Light-intensity physical activities and mortality in the United States general population and CKD subpopulation. Clin J Am Soc Nephrol 10(7):1145\u20131153. https:\/\/doi.org\/10.2215\/CJN.08410814","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"2345_CR27","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1681\/ASN.2013070702","volume":"25","author":"JL Viana","year":"2014","unstructured":"Viana JL, Kosmadakis GC, Watson EL et al (2014) Evidence for anti-inflammatory effects of exercise in CKD. J Am Soc Nephrol 25(9):2121\u20132130","journal-title":"J Am Soc Nephrol"},{"key":"2345_CR28","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2165\/00007256-199927020-00001","volume":"27","author":"DC Nieman","year":"1999","unstructured":"Nieman DC, Pedersen BK (1999) Exercise and immune function: recent developments. Sports Med 27:73\u201380","journal-title":"Sports Med"},{"issue":"8","key":"2345_CR29","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1001\/jamainternmed.2022.2488","volume":"182","author":"M Dos Santos","year":"2022","unstructured":"Dos Santos M, Ferrari G, Lee DH et al (2022) Association of the \u201cWeekend Warrior\u201d and other leisure-time physical activity patterns with all-cause and cause-specific mortality: a nationwide cohort study. JAMA Intern Med 182(8):840\u2013848. https:\/\/doi.org\/10.1001\/jamainternmed.2022.2488","journal-title":"JAMA Intern Med"},{"issue":"3","key":"2345_CR30","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1001\/jama.2023.10875","volume":"330","author":"S Khurshid","year":"2023","unstructured":"Khurshid S, Al-Alusi MA, Churchill TW et al (2023) Accelerometer-derived \u201cWeekend Warrior\u201d physical activity and incident cardiovascular disease. JAMA 330(3):247\u2013252. https:\/\/doi.org\/10.1001\/jama.2023.10875","journal-title":"JAMA"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-025-02345-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-025-02345-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-025-02345-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:59:41Z","timestamp":1777564781000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/38\/8\/2375\/8461732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["2345"],"URL":"https:\/\/doi.org\/10.1007\/s40620-025-02345-y","relation":{},"ISSN":["1724-6059"],"issn-type":[{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"3 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki. The UK Biobank study has approval from the Northwest Multicenter Research Ethics Committee approval (approval number: 21\/NW\/0157).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The protocols for animal experiments were approved by the Committee for the Care and Use of Laboratory Animals at Yonsei University College of Medicine (Approval No. 2022-0238). All experiments with animals were conducted in accordance with the Principles of Laboratory Animal Care (NIH Publication No. 85\u201323, revised 1985). This study does not include any research involving humans.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"All participants provided written informed consent.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent to participate"}}]}}