{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T03:03:49Z","timestamp":1794452629503,"version":"4.9.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100007861","name":"Institute of Food and Agricultural Sciences, University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"crossref","award":["1059B192301773"],"award-info":[{"award-number":["1059B192301773"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nephrol"],"DOI":"10.1007\/s40620-025-02353-y","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T14:13:54Z","timestamp":1752329634000},"page":"1629-1638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of almond milk fortified with vitamin D3-loaded soy protein nanoparticles on serum 25(OH)D3 concentrations in adults with CKD: a pilot double-blind randomized controlled trial"],"prefix":"10.1093","volume":"38","author":[{"given":"Li-Ying","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca Nuria","family":"Casta\u0598neda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyi E.","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1649-3586","authenticated-orcid":false,"given":"Jiyan","family":"Aslan Ceylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-9169","authenticated-orcid":false,"given":"Juan E.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-4546","authenticated-orcid":false,"given":"Jeanette M.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"2353_CR1","doi-asserted-by":"publisher","first-page":"iii35","DOI":"10.1093\/ndt\/gfy175","volume":"33","author":"G Cobo","year":"2018","unstructured":"Cobo G, Lindholm B, Stenvinkel P (2018) Chronic inflammation in end-stage renal disease and dialysis. Nephrol Dial Transpl 33:iii35\u2013iii40","journal-title":"Nephrol Dial Transpl"},{"key":"2353_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1053\/j.arrt.2003.08.008","volume":"10","author":"K Kalantar-Zadeh","year":"2003","unstructured":"Kalantar-Zadeh K, Stenvinkel P, Pillon L, Kopple JD (2003) Inflammation and nutrition in renal insufficiency. Adv Ren Replace Ther 10:155\u2013169","journal-title":"Adv Ren Replace Ther"},{"key":"2353_CR3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/ejcn.2017.59","volume":"71","author":"RJ Lu","year":"2017","unstructured":"Lu RJ, Zhu SM, Tang FL, Zhu XS, Fan ZD, Wang GL, Jiang YF, Zhang Y (2017) Effects of vitamin D or its analogues on the mortality of patients with chronic kidney disease: an updated systematic review and meta-analysis. Eur J Clin Nutr 71:683\u2013693. https:\/\/doi.org\/10.1038\/ejcn.2017.59","journal-title":"Eur J Clin Nutr"},{"key":"2353_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4673","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Fang F, Faramand A (2020) Association between vitamin D supplementation and mortality: systematic review and meta-analysis. Br Med J. https:\/\/doi.org\/10.1136\/bmj.l4673","journal-title":"Br Med J"},{"key":"2353_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph15081773","volume":"15","author":"PHF Gois","year":"2018","unstructured":"Gois PHF, Wolley M, Ranganathan D, Seguro AC (2018) Vitamin D deficiency in chronic kidney disease: recent evidence and controversies. Int J Environ Res Public Health 15:1\u201316. https:\/\/doi.org\/10.3390\/ijerph15081773","journal-title":"Int J Environ Res Public Health"},{"key":"2353_CR6","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1053\/j.ajkd.2014.05.018","volume":"64","author":"H Kramer","year":"2014","unstructured":"Kramer H, Berns JS, Choi MJ, Martin K, Rocco MV (2014) 25-hydroxyvitamin D testing and supplementation in CKD: an NKF-KDOQI controversies report. Am J Kidney Dis 64:499\u2013509. https:\/\/doi.org\/10.1053\/j.ajkd.2014.05.018","journal-title":"Am J Kidney Dis"},{"key":"2353_CR7","unstructured":"National Institutes of Health. Vitamin D: Fact Sheet for Health Professionals Available online: https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/. Accessed 5 Oct 2020"},{"key":"2353_CR8","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","volume":"76","author":"TA Ikizler","year":"2020","unstructured":"Ikizler TA, Burrowes JD, Byham-Gray LD, Campbell KL, Carrero JJ, Chan W, Fouque D, Friedman AN, Ghaddar S, Goldstein-Fuchs DJ et al (2020) KDOQI clinical practice guideline for nutrition in CKD: 2020 update. Am J Kidney Dis 76:S1\u2013S107. https:\/\/doi.org\/10.1053\/j.ajkd.2020.05.006","journal-title":"Am J Kidney Dis"},{"key":"2353_CR9","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1053\/j.jrn.2017.07.008","volume":"28","author":"JT Kelly","year":"2018","unstructured":"Kelly JT, Campbell KL, Hoffmann T, Reidlinger DP (2018) Patient experiences of dietary management in chronic kidney disease: a focus group study. J Ren Nutr 28:393\u2013402. https:\/\/doi.org\/10.1053\/j.jrn.2017.07.008","journal-title":"J Ren Nutr"},{"key":"2353_CR10","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1016\/j.clinthera.2023.08.007","volume":"45","author":"A Al-Khulaifi","year":"2023","unstructured":"Al-Khulaifi A, Khatib M, Ali E, Ali MY, Danjuma MIM (2023) What is polypharmacy in patients with chronic kidney disease? A systematic review. Clin Ther 45:e217\u2013e221. https:\/\/doi.org\/10.1016\/j.clinthera.2023.08.007","journal-title":"Clin Ther"},{"key":"2353_CR11","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3390\/nu15030593","volume":"15","author":"MF Holick","year":"2023","unstructured":"Holick MF (2023) The one-hundred-year anniversary of the discovery of the sunshine vitamin D3: historical personal experience and evidence-based perspectives. Nutrients 15:593","journal-title":"Nutrients"},{"key":"2353_CR12","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/J.JOR.2022.10.017","volume":"35","author":"RK Marwaha","year":"2023","unstructured":"Marwaha RK, Verma M, Walekar A, Sonawane R, Trivedi C (2023) An open-label, randomized, crossover study to evaluate the bioavailability of nanoemulsion versus conventional fat-soluble formulation of cholecalciferol in healthy participants. J Orthop 35:64\u201368. https:\/\/doi.org\/10.1016\/J.JOR.2022.10.017","journal-title":"J Orthop"},{"key":"2353_CR13","doi-asserted-by":"publisher","first-page":"4484","DOI":"10.1002\/fsn3.1750","volume":"8","author":"P Sharifan","year":"2020","unstructured":"Sharifan P, Khoshakhlagh M, Khorasanchi Z, Darroudi S, Rezaie M, Safarian M, Vatanparast H, Afshari A, Ferns G, Ghazizadeh H et al (2020) Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D3 on improvement in symptoms of insomnia and quality of life: evidence from the SUVINA trial. Food Sci Nutr 8:4484\u20134490. https:\/\/doi.org\/10.1002\/fsn3.1750","journal-title":"Food Sci Nutr"},{"key":"2353_CR14","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.foodhyd.2015.11.022","volume":"55","author":"H Lee","year":"2016","unstructured":"Lee H, Yildiz G, dos Santos LC, Jiang S, Andrade JE, Engeseth NJ, Feng H (2016) Soy protein nano-aggregates with improved functional properties prepared by sequential PH treatment and ultrasonication. Food Hydrocoll 55:200\u2013209. https:\/\/doi.org\/10.1016\/j.foodhyd.2015.11.022","journal-title":"Food Hydrocoll"},{"key":"2353_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/nano11040887","author":"Y Akkam","year":"2021","unstructured":"Akkam Y, Rababah T, Costa R, Almajwal A, Feng H, Laborde JEA, Abulmeaty MM, Razak S (2021) Pea protein nanoemulsion effectively stabilizes vitamin d in food products: a potential supplementation during the Covid-19 pandemic. Nanomaterials. https:\/\/doi.org\/10.3390\/nano11040887","journal-title":"Nanomaterials"},{"key":"2353_CR16","unstructured":"United States Food and Drug Administration. Vitamin D for Milk and Milk Alternatives Available online: https:\/\/www.fda.gov\/food\/food-additives-petitions\/vitamin-d-milk-and-milk-alternatives. Accessed 5 May 2025"},{"key":"2353_CR17","doi-asserted-by":"publisher","first-page":"215","DOI":"10.4085\/1062-6050-43.2.215","volume":"43","author":"M Kang","year":"2008","unstructured":"Kang M, Ragan BG, Park J-H (2008) Issues in outcomes research: an overview of randomization techniques for clinical trials. J Athl Train 43:215","journal-title":"J Athl Train"},{"key":"2353_CR18","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1056\/nejmoa2102953","volume":"385","author":"LA Inker","year":"2021","unstructured":"Inker LA, Eneanya ND, Coresh J, Tighiouart H, Wang D, Sang Y, Crews DC, Doria A, Estrella MM, Froissart M et al (2021) New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med 385:1737\u20131749. https:\/\/doi.org\/10.1056\/nejmoa2102953","journal-title":"N Engl J Med"},{"key":"2353_CR19","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s11947-019-02276-0","volume":"12","author":"S Jiang","year":"2019","unstructured":"Jiang S, Yildiz G, Ding J, Andrade J, Rababahb TM, Almajwalc A, Abulmeatyc MM, Feng H (2019) Pea protein nanoemulsion and nanocomplex as carriers for protection of cholecalciferol (vitamin D3). Food Bioproc Tech 12:1031\u20131040. https:\/\/doi.org\/10.1007\/s11947-019-02276-0","journal-title":"Food Bioproc Tech"},{"key":"2353_CR20","doi-asserted-by":"publisher","first-page":"7576","DOI":"10.1021\/jf901585n","volume":"57","author":"J Jiang","year":"2009","unstructured":"Jiang J, Chen J, Xiong YL (2009) Structural and emulsifying properties of soy protein isolate subjected to acid and alkaline PH-shifting processes. J Agric Food Chem 57:7576\u20137583","journal-title":"J Agric Food Chem"},{"key":"2353_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.899300","author":"JM Andrade","year":"2022","unstructured":"Andrade JM, Grandoff PG, Schneider ST (2022) Vitamin D intake and factors associated with self-reported vitamin D deficiency among US adults: a 2021 cross-sectional study. Front Nutr. https:\/\/doi.org\/10.3389\/fnut.2022.899300","journal-title":"Front Nutr"},{"key":"2353_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu11112732","volume":"11","author":"DE Larson-meyer","year":"2019","unstructured":"Larson-meyer DE, Douglas CS, Thomas JJ, Johnson EC, Barcal JN, Heller JE, Hollis BW, Halliday TM (2019) Validation of a vitamin D specific questionnaire to determine vitamin D status in athletes. Nutrients 11:1\u201314","journal-title":"Nutrients"},{"key":"2353_CR23","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","volume":"96","author":"MF Holick","year":"2011","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM (2011) Evaluation, Treatment, and Prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 96:1911\u20131930. https:\/\/doi.org\/10.1210\/jc.2011-0385","journal-title":"J Clin Endocrinol Metab"},{"key":"2353_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/mnfr.201700836","volume":"62","author":"AS Kadappan","year":"2018","unstructured":"Kadappan AS, Guo C, Gumus CE, Bessey A, Wood RJ, McClements DJ, Liu Z (2018) The efficacy of nanoemulsion-based delivery to improve vitamin D absorption: comparison of in vitro and in vivo studies. Mol Nutr Food Res 62:1\u20138. https:\/\/doi.org\/10.1002\/mnfr.201700836","journal-title":"Mol Nutr Food Res"},{"key":"2353_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010075","author":"AM Almajwal","year":"2019","unstructured":"Almajwal AM, Abulmeaty MMA, Feng H, Alruwaili NW, Dominguez-Uscanga A, Andrade JE, Razak S, Elsadek MF (2019) Stabilization of vitamin D in pea protein isolate nanoemulsions increases its bioefficacy in rats. Nutrients. https:\/\/doi.org\/10.3390\/nu11010075","journal-title":"Nutrients"},{"key":"2353_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/J.LWT.2023.115680","volume":"191","author":"H Gong","year":"2024","unstructured":"Gong H, Fu H, Zhang J, Zhang Q, Wang Y, Wang D, Cai L, Chen J, Yu H, Lyu B (2024) Preparation of soybean protein-based nanoparticles and its application as encapsulation carriers of bioactive substances. LWT 191:115680. https:\/\/doi.org\/10.1016\/J.LWT.2023.115680","journal-title":"LWT"},{"key":"2353_CR27","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.foodhyd.2014.05.010","volume":"43","author":"Z Li","year":"2015","unstructured":"Li Z, Jiang H, Xu C, Gu L (2015) A review: using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals. Food Hydrocoll 43:153\u2013164","journal-title":"Food Hydrocoll"},{"key":"2353_CR28","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1017\/S0007114521002816","volume":"127","author":"B Nikooyeh","year":"2022","unstructured":"Nikooyeh B, Neyestani TR (2022) The effects of vitamin D-fortified foods on circulating 25(OH)D concentrations in adults: a systematic review and meta-analysis. Br J Nutr 127:1821\u20131838","journal-title":"Br J Nutr"},{"key":"2353_CR29","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.nefro.2018.07.004","volume":"39","author":"MP Cardoso","year":"2019","unstructured":"Cardoso MP, Pereira LAL (2019) Native vitamin D in pre-dialysis chronic kidney disease. Nefrologia 39:18\u201328. https:\/\/doi.org\/10.1016\/j.nefro.2018.07.004","journal-title":"Nefrologia"},{"key":"2353_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s41043-022-00283-0","author":"P Sharifan","year":"2022","unstructured":"Sharifan P, Rashidmayvan M, Khorasanchi Z, Darroudi S, Heidari A, Hoseinpoor F, Vatanparast H, Safarian M, Eslami S, Afshari A et al (2022) Efficacy of low-fat milk and yogurt fortified with vitamin D3 on systemic inflammation in adults with abdominal obesity. J Health Popul Nutr. https:\/\/doi.org\/10.1186\/s41043-022-00283-0","journal-title":"J Health Popul Nutr"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-025-02353-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40620-025-02353-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40620-025-02353-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:59:33Z","timestamp":1777564773000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/38\/6\/1629\/8457523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,12]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["2353"],"URL":"https:\/\/doi.org\/10.1007\/s40620-025-02353-y","relation":{},"ISSN":["1724-6059"],"issn-type":[{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,12]]},"assertion":[{"value":"11 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors certify that they have no affiliations with, or involvement in, any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Local Research Ethics Committee (University of Florida Institutional Review Board (IRB)# 202102986 on February 1, 2022). This study was registered on ClinicalTrial.gov on December 21, 2021: NCT05165173.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from each participant before their enrollment in the study. Participants signed the informed consent form regarding the publication of their collected and analyzed data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}