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We examined clinical determinants of LV mass in children with ARPKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective study of patients with ARPKD with available echocardiogram data. Casual blood pressure (BP) percentiles, 24-h ambulatory BP monitor (ABPM) parameters, antihypertensive medications, and estimated glomerular filtration rate (eGFR) within 6\u00a0months of echocardiogram were collected. Outcomes included LV mass Z-score, LV mass index [LVMI in g\/m\n                      <jats:sup>2.7<\/jats:sup>\n                      and g\/(m\n                      <jats:sup>2.16<\/jats:sup>\n                      \u2009+\u20090.09)], and LVH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty patients with ARPKD (median age 7.2\u00a0years [IQR 3.4, 12.8]) had echocardiograms, 28 had casual BPs, 11 had ABPMs, and 93% were on antihypertensives. LVH occurred in 23% based on LVMI in g\/m\n                      <jats:sup>2.7<\/jats:sup>\n                      \u2009&gt;\u200995th percentile, and in 50% based on LVMI\u2009&gt;\u200945\u00a0g\/(m\n                      <jats:sup>2.16<\/jats:sup>\n                      \u2009+\u20090.09). Younger age correlated with higher number of antihypertensives (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u2212\u00a00.46,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014) and higher casual systolic and diastolic BP percentiles (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212\u00a00.74,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212\u00a00.81,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). After adjusting for age, sex, and eGFR, LV mass was not significantly associated with casual BP or ABPM, except for a negative association between LV mass Z-score and casual diastolic BP percentile (\u03b2 coefficient \u2212\u00a00.31,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04). After adjusting for age, sex, and casual BP, both LVMI [in g\/m\n                      <jats:sup>2.7<\/jats:sup>\n                      and g\/(m\n                      <jats:sup>2.16<\/jats:sup>\n                      \u2009+\u20090.09)] and LV mass Z-score were significantly negatively associated with eGFR (\u03b2 \u20131.08,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003; \u03b2 \u20130.79,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007; and \u03b2 -0.07,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Young children with ARPKD have a higher burden of hypertension. LV mass was unexpectedly not significantly associated with BP but was negatively associated with eGFR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-025-02426-y","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T02:16:27Z","timestamp":1759803387000},"page":"2949-2960","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of left ventricular mass in children with autosomal recessive polycystic kidney disease"],"prefix":"10.1093","volume":"38","author":[{"given":"Mathew","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-6022","authenticated-orcid":false,"given":"Jeremy","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-7871","authenticated-orcid":false,"given":"Robert A.","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-1160","authenticated-orcid":false,"given":"Jarcy","family":"Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-6505","authenticated-orcid":false,"given":"Erum A.","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"2426_CR1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3389\/fped.2017.00080","volume":"5","author":"B Alzarka","year":"2017","unstructured":"Alzarka B, Morizono H, Bollman JW et al (2017) Design and implementation of the Hepatorenal Fibrocystic Disease Core Center clinical database: a centralized resource for characterizing autosomal recessive polycystic kidney disease and other hepatorenal fibrocystic diseases. 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