{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:40:56Z","timestamp":1770417656035,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2023IP0112"],"award-info":[{"award-number":["2023IP0112"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2023IP0112"],"award-info":[{"award-number":["2023IP0112"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pauci-immune glomerulonephritis (GN) is a typical renal manifestation of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, patients positive for ANCA can present with kidney pathologies other than pauci-immune GN. This study aimed to investigate and compare the characteristics of ANCA-positive patients diagnosed with pauci-immune GN to those with non-pauci-immune kidney diseases, based on kidney biopsy findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the electronic medical records of ANCA-positive patients who underwent kidney biopsy from January 2010 to October 2023 at a single tertiary center in Seoul, Republic of Korea. Logistic regression analysis was performed to identify variables associated with the diagnosis of\u00a0pauci-immune GN\u00a0in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 268 ANCA-positive patients, 195 (72.8%) were diagnosed with pauci-immune GN, while 73 (27.2%) had other kidney diseases. The most common pathologies in the non-pauci-immune GN group were IgA nephropathy (20.5%) and lupus nephritis (16.4%). Compared to the non-pauci-immune GN group, patients with pauci-immune GN exhibited higher platelet counts and C-reactive protein (CRP) levels, along with lower estimated glomerular filtration rate (eGFR). Urine abnormalities, categorized by the presence or absence of hematuria and\/or proteinuria, differed significantly between the groups. Multivariate analysis identified hematuria and pulmonary involvement as significant predictors of pauci-immune GN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately 70% of our ANCA-positive patients who underwent kidney biopsy were diagnosed with pauci-immune GN. Predictive factors for pauci-immune GN included platelet count, CRP levels, eGFR, hematuria, and pulmonary involvement. Identifying these clinical and laboratory\u00a0markers may be valuable for improving the diagnostic approach towards AAV-related kidney manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1007\/s40620-025-02430-2","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:56:21Z","timestamp":1760536581000},"page":"2919-2928","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors associated with pauci-immune glomerulonephritis in patients undergoing kidney biopsy with positive anti-neutrophil cytoplasmic antibody results"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1050-673X","authenticated-orcid":false,"given":"Yeo-Jin","family":"Lee","sequence":"first","affiliation":[{"name":"https:\/\/ror.org\/02c2f8975 grid.267370.7 0000 0004 0533 4667 Division of Rheumatology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine 88, Olympic-Ro 43-Gil, Songpa-Gu 05505 Seoul Republic of Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4719-3691","authenticated-orcid":false,"given":"Jiyun","family":"Lee","sequence":"additional","affiliation":[{"name":"https:\/\/ror.org\/02tec3785 grid.469228.3 0000 0004 0647 8742 University of Ulsan College of Medicine Seoul Republic of Korea 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-9768","authenticated-orcid":false,"given":"Soo Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"https:\/\/ror.org\/02c2f8975 grid.267370.7 0000 0004 0533 4667 Division of Rheumatology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine 88, Olympic-Ro 43-Gil, Songpa-Gu 05505 Seoul Republic of Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-8320","authenticated-orcid":false,"given":"Ji Seon","family":"Oh","sequence":"additional","affiliation":[{"name":"https:\/\/ror.org\/02c2f8975 grid.267370.7 0000 0004 0533 4667 Department of Information Medicine, Big Data Research Center, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-7355","authenticated-orcid":false,"given":"Yong-Gil","family":"Kim","sequence":"additional","affiliation":[{"name":"https:\/\/ror.org\/02c2f8975 grid.267370.7 0000 0004 0533 4667 Division of Rheumatology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine 88, Olympic-Ro 43-Gil, Songpa-Gu 05505 Seoul Republic of Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3653-7515","authenticated-orcid":false,"given":"Chang-Keun","family":"Lee","sequence":"additional","affiliation":[{"name":"https:\/\/ror.org\/02c2f8975 grid.267370.7 0000 0004 0533 4667 Division of Rheumatology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine 88, Olympic-Ro 43-Gil, Songpa-Gu 05505 Seoul Republic of Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-5273","authenticated-orcid":false,"given":"Bin","family":"Yoo","sequence":"additional","affiliation":[{"name":"https:\/\/ror.org\/02c2f8975 grid.267370.7 0000 0004 0533 4667 Division of Rheumatology, Department of Internal 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March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and its subsequent amendments. The Institutional Review Board of Asan Medical Center approved the study (2023\u20131534). Given the retrospective nature of the study, the requirement for informed consent was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}